Idebenone

Catalog No.S2605 Synonyms: CV-2619

Idebenone Chemical Structure

Molecular Weight(MW): 338.44

Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 247 In stock
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Biological Activity

Description Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.
In vitro

Idebenone effectively protects from retinal cell injury after oxidative stress or hypoglycemia, whereas the protection afforded after postincubation of both antioxidants is decreased. Idebenone attenuates delayed retinal cell damage, mediated by chemical ischemia. [1] Idebenone, a centrally active antioxidant used to treat multiinfarct dementia, protects cells from this form of glutamate-induced cytotoxicity in vitro. Idebenone provides significant protection against the neuronal degeneration induced by intrastriatal injection of kainic acid and quisqualic acid, but not the NMDA receptor agonist, quinolinic acid. [2]

In vivo Idebenone prevents the behavioural deficits in Y-maze and water maze, but not passive avoidance, tasks in A beta-(1-42)-infused rats when they are repeatedly administered by mouth once a day from 3 days before the start of A beta infusion to the end of behavioural experiments. [3] Idebenone (100 and 300 mg/kg) is orally administered to rats for 3 days, it increases the state 3 respiration stimulated by ADP, slightly decreasez the state 4 respiration after the consumption of ADP and resultz in a significant increase of the respiratory control index (RCI) by 14-19% for glutamate oxidation and 10-17% for succinate oxidation, respectively. Idebenone significantly suppresses by about 10% the non-respiratory oxygen consumption, which closely associated with non-enzymatic reactions such as lipid peroxidation, membrane lysis and swelling of mitochondria. [4]

Protocol

Solubility (25°C)

In vitro DMSO 68 mg/mL (200.92 mM)
Ethanol 68 mg/mL (200.92 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 338.44
Formula

C19H30O5

CAS No. 58186-27-9
Storage powder
Synonyms CV-2619

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00229632 Completed Friedreich Ataxia National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) September 23, 2005 Phase 2
NCT01854359 Enrolling by invitation Multiple Sclerosis|Primary Progressive Multiple Sclerosis National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) February 22, 2013 Phase 1|Phase 2
NCT02814019 Recruiting Duchenne Muscular Dystrophy (DMD) Santhera Pharmaceuticals September 2016 Phase 3
NCT02887443 Completed Drug-Drug Interaction Santhera Pharmaceuticals September 2016 Phase 1
NCT02771379 Not yet recruiting Lebers Hereditary Optic Neuropathy (LHON) Santhera Pharmaceuticals June 2016 --
NCT02774005 Recruiting Lebers Hereditary Optic Neuropathy (LHON) Santhera Pharmaceuticals May 2016 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID