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Tiopronin ROS chemical

Cat.No.S2062

Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
Tiopronin ROS chemical Chemical Structure

Chemical Structure

Molecular Weight: 163.19

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Quality Control

Batch: S206201 DMSO]32 mg/mL]false]Water]32 mg/mL]false]Ethanol]32 mg/mL]false Purity: 99.54%
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99.54

Solubility

In vitro
Batch:

DMSO : 32 mg/mL (196.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 32 mg/mL

Ethanol : 32 mg/mL

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 163.19 Formula

C5H9NO3S

 Storage (From the date of receipt)
CAS No. 1953-02-2 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC(C(=O)NCC(=O)O)S

Mechanism of Action

In vitro
Tiopronin is an antioxidant with a free thiol (sulfidryl) group that has been shown to protect against cisplatin nephrotoxicity both in vitro and in vivo. This compound improves the defence of the cochlea and scavenge the reactive oxygen species, whereas vitamin E (a-tocopherol) and vitamin C act by inhibiting lipid peroxidation and preventing free radical formation. This chemical (2 mM) completely prevents the Cisplatin-induced increase in enzyme leakage and substantially blocks the decrease of MTT reduction caused by Cisplatin. It also significantly protects the renal slices from cisplatin-induced toxic effects. This agent protects against cisplatin-induced nephrotoxicity by acting as an alternative target for Cisplatin both intra- and extracellularly and thus protects against cisplatin-induced depletion of glutathione in the kidney cell. It protects rat kidney slices in vitro from the nephrotoxic effects of Cisplatin and does not reduce the antitumour activity of Cisplatin. This compound provides marked protection againstcisplatin-induced increases in urea and creatinine. It protects against Cisplatin-induced changes in the adenine nucleotides in rat renal cortical slices.
In vivo
Tiopronin significantly lowers both the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, while only the serum ALT level is lowered by ursodeoxycholic acid (UDCA) in rats. This compound significantly decreases the serum and liver levels of triglyceride (TG), total cholesterol (TC) and free fatty acids (FFA) as well as the serum LDL-C level, and increases the serum HDL-C level.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/9401952/
  • [5] https://pubmed.ncbi.nlm.nih.gov/22543705/

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