Tiopronin

Catalog No.S2062

Tiopronin  Chemical Structure

Molecular Weight(MW): 163.19

Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.

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In DMSO USD 130 In stock
USD 60 In stock
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Description Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
In vitro

Tiopronin is an antioxidant with a free thiol (sulfidryl) group that has been shown to protect against cisplatin nephrotoxicity both in vitro and in vivo. Tiopronin improves the defence of the cochlea and scavenge the reactive oxygen species, whereas vitamin E (a-tocopherol) and vitamin C act by inhibiting lipid peroxidation and preventing free radical formation. [1] Tiopronin (2 mM) completely prevents the Cisplatin-induced increase in enzyme leakage and substantially blocks the decrease of MTT reduction caused by Cisplatin. Tiopronin also significantly protects the renal slices from cisplatin-induced toxic effects. Tiopronin protects against cisplatin-induced nephrotoxicity by acting as an alternative target for Cisplatin both intra- and extracellularly and thus protects against cisplatin-induced depletion of glutathione in the kidney cell. [2] Tiopronin protects rat kidney slices in vitro from the nephrotoxic effects of Cisplatin and does not reduce the antitumour activity of Cisplatin. Tiopronin provides marked protection againstcisplatin-induced increases in urea and creatinine. [3] Tiopronin protects against Cisplatin-induced changes in the adenine nucleotides in rat renal cortical slices. [4]

In vivo Tiopronin significantly lowers both the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, while only the serum ALT level is lowered by ursodeoxycholic acid (UDCA) in rats. Tiopronin significantly decreases the serum and liver levels of triglyceride (TG), total cholesterol (TC) and free fatty acids (FFA) as well as the serum LDL-C level, and increases the serum HDL-C level. [5]

Protocol

Solubility (25°C)

In vitro DMSO 32 mg/mL (196.09 mM)
Water 32 mg/mL (196.09 mM)
Ethanol 32 mg/mL (196.09 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 163.19
Formula

C5H9NO3S

CAS No. 1953-02-2
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01095731 Completed Aneurysmal Subarachnoid Hemorrhage E. Sander Connolly|University of Florida|University of Washington|Columbia University April 2010 Phase 2
NCT02734966 Completed Drug-Induced Liver Injury Chia Tai Tianqing Pharmaceutical Group Co., Ltd. December 2007 Phase 2

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