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Tubastatin A hydrochloride Chemical Structure
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Biological Activity
Tubastatin A hydrochloride is a potent selective HDAC6 inhibitor with an IC50 of 15 nM. For a comparison, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 μM), excluding HDAC8 (IC50 = 0.9 μM), where it displayed 54-fold selectivity. For example, tubastatin A inhibits HDAC1 with an IC50 of 16.4 μM. Tubastatin A hydrochloride induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM. [1]
Chemical Information
| Molecular Weight (WM): | 371.86 |
|---|---|
| Formula: | C20H21N3O2.HCl |
| CAS No.: | 1310693-92-5 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥8mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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