Research Area
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MC1568 Chemical Structure
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Biological Activity
MC1568 is a potent selective class II (IIa) histone deacetylas (HDAC II) inhibitor (IC50 of a maize deacetylase HD2 at 22.0 µM). MC1568 had no or a weak effect on the class I HDACs. MC1568 shows no inhibitory activity against HDAC1 but was able to inhibit HDAC4. [1]
References on MC1568
- [1] Mol Cancer Res 2008 December;6(12): 1908–1919
Chemical Information
| Molecular Weight (WM): | 314.31 |
|---|---|
| Formula: | C17H15FN2O3 |
| CAS No.: | 852475-26-4 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥13mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Selleck's high quality products have been used in several published research findings, including the following:
An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease*
Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription: rational therapeutic approach to frontotemporal dementia
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Click to enlarge
Western blot analysis of p-histone and histone. 0-10μM MC1588 was added.
Western blot analysis of p-histone and histone. 0-10μM MC1588 was added.
Data independently produced by Dr. Zhang of Tianjin Medical University MC1568 purchased from Selleck
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Click to enlarge
Class-specific histone deacetylase inhibition ameliorates cholesterol accumulation. Mutant fibroblasts (NPC-26) were incubated for 18 h in the presence of the HDAC class-specific inhibitors MC1568 and MGCD0103 (5 M) and assessed for cholesterol accumulation by filipin fluorescence. Quantification of filipin fluorescence is expressed as arbitrary units. *, p 0.05, treated versus untreated cells by two-tailed Student’s t test. - Class-specific histone deacetylase inhibition ameliorates cholesterol accumulation. Mutant fibroblasts (NPC-26) were incubated for 18 h in the presence of the HDAC class-specific inhibitors MC1568 and MGCD0103 (5 M) and assessed for cholesterol accumulation by filipin fluorescence. Quantification of filipin fluorescence is expressed as arbitrary units. *, p 0.05, treated versus untreated cells by two-tailed Student’s t test.
Data from [J Biol Chem 2011.July;286:23842–23851] MC1568 purchased from Selleck
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Western blot analysis of p-histone and histone. 0-10μM MC1588 was added.
|
Data independently produced by Dr. Zhang of Tianjin Medical University
| Class-specific histone deacetylase inhibition ameliorates cholesterol accumulation. Mutant fibroblasts (NPC-26) were incubated for 18 h in the presence of the HDAC class-specific inhibitors MC1568 and MGCD0103 (5 M) and assessed for cholesterol accumulation by filipin fluorescence. Quantification of filipin fluorescence is expressed as arbitrary units. *, p 0.05, treated versus untreated cells by two-tailed Student’s t test. |
Data from [J Biol Chem 2011.July;286:23842–23851]
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