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LAQ824 (NVP-LAQ824) Chemical Structure
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Biological Activity
LAQ824 (NVP-LAQ824) (a cinnamic hydroxamic acid), a histone deacetylase inhibitor, inhibited in vitro enzymatic activities(IC50= 0.032uM)and transcriptionally activated the p21 promoter in reporter gene assays(IC50= 0.3 μM).
LAQ824 (NVP-LAQ824) selectively inhibited growth of cancer cell lines at submicromolar levels after 48-72 h of exposure, The calculated IC50s were 0.15 and 0.01 μM in H1299 and HCT116 cells, respectively.[1] In addition, LAQ824 exhibited antitumor effects in a xenograft animal model. [2,3]
References on LAQ824 (NVP-LAQ824)
- [1] Cancer Res 2004;64:689-695
- [2] Blood 2003;102: 2615-2622
- [3] Clin Cancer Res 2008;14:6663-6673
Chemical Information
| Molecular Weight (WM): | 379.459 |
|---|---|
| Formula: | C22H25N3O3 |
| CAS No.: | 404951-53-7 |
| Synonyms: |
Dacinostat
|
| Dissolve in (25°C): | DMSO ≥76mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Selleck's high quality products have been used in several published research findings, including the following:
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
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Click to enlarge
Western blot analysis of Acetyl-H3 and H3. 0-10μM LAQ824 was added.
Western blot analysis of Acetyl-H3 and H3. 0-10μM LAQ824 was added.
Data independently produced by Dr.Zhang of Tianjin Medical University LAQ824 (NVP-LAQ824) purchased from Selleck
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Click to enlarge
Mice received intrathecally injected vehicle or LAQ824 at indicated dose 30 min before unilateral injection of CFA. Paw withdrawal latency was measured before injections as baseline, and after CFA injections as hyperalgesia response.
Mice received intrathecally injected vehicle or LAQ824 at indicated dose 30 min before unilateral injection of CFA. Paw withdrawal latency was measured before injections as baseline, and after CFA injections as hyperalgesia response.
Data from [Molecular Pain 2010;6:51] LAQ824 (NVP-LAQ824) purchased from Selleck
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Western blot analysis of Acetyl-H3 and H3. 0-10μM LAQ824 was added.
|
Data independently produced by Dr.Zhang of Tianjin Medical University
Mice received intrathecally injected vehicle or LAQ824 at indicated dose 30 min before unilateral injection of CFA. Paw withdrawal latency was measured before injections as baseline, and after CFA injections as hyperalgesia response.
|
Data from [Molecular Pain 2010;6:51]
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