ITSA-1 (ITSA1)

Catalog No.S8323

ITSA-1 (ITSA1) Chemical Structure

Molecular Weight(MW): 292.12

ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors.

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Biological Activity

Description ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors.
Targets
HDAC [1]

Protocol

Cell Research:[1]
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  • Cell lines: A549 cells
  • Concentrations: 50 μM
  • Incubation Time: 17.5 h
  • Method: A549 cells ( 75% confluent) in 10-cm dishes are treated with DMSO (0.1%), TSA (500 nM), or tubacin (2 μM) for 4.5 h, and then either DMSO (0.1%) or ITSA1 (50 μM) is added for an additional 17.5 h. Samples are rinsed in PBS, trypsinized, and fixed for 2 h in 70% ethanol 30% PBS (4°C). Cells then are washed once in PBS and stored overnight in PBS (4°C).
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 58 mg/mL (198.54 mM)
Ethanol 5 mg/mL (17.11 mM)
Water slightly soluble or insoluble
In vivo Add solvents individually and in order:

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 292.12
Formula

C13H7Cl2N3O

CAS No. 200626-61-5
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID