Sodium butyrate

Catalog No.S1999

Sodium butyrate Chemical Structure

Molecular Weight(MW): 110.09

Sodium butyrate, sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).

Size Price Stock Quantity  
USD 50 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

2 Customer Reviews

  • U87 cells were cultured with DMSO or 10 µM 5azadC for 72 h. For the latter, 1 µM Trichostatin A (TSA), 10 mM sodium butyrate (NaBu), 5 mM nicotinamide (NAM), or 0.5 µM apicidin were added in the last 24 h. IFNLR1 expression was determined by RT-qPCR.

    PLoS Biol 2014 12(1), e1001758. Sodium butyrate purchased from Selleck.

    Effects of combination of either MS-275, apicidin, SAHA or sodium butyrate (NaB) with bortezomib on proliferation of Wp-restricted BL cells. P3HR1-c16 cells were treated with combination of NaB (0, 0.6, 1.2, 2.4, 4.8 and 9.6 mM) for 48 h. Cell proliferation was determined by MTT assay and presented as percentages of cell proliferation of treated cells compared with those of untreated cells. Synergisms of proliferation inhibition of the cells following treatment with different drug combinations were analysed by isobologram analysis.

    Br J Haematol 2014 167(5), 639-50. Sodium butyrate purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Sodium butyrate, sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).
Targets
Histone deacetylase [6]
In vitro

Butyrate mediates growth inhibition of colonic cancer cells and thereby to elucidate the molecular link between a high-fiber diet and the arrest of colon carcinogenesis. Butyrate induces p21 mRNA expression in an immediate-early fashion, through transactivation of a promoter cis-element(s) located within 1.4 kb of the transcriptional start site, independent of p53 binding. [1] Sodium butyrate, at physiological concentrations, induces apoptosis in 2 adenoma cell lines, RG/C2 and AA/Cl, and in the carcinoma cell line PC/JW/FI. [2] Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. [3] Butyrate inhibits most HDAC except class III HDAC and class II HDAC6 and -10. Butyrate also is the most effective fatty acid in stimulating or repressing the expression of specific genes. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human K562 cells M1uzOXBzd2yrZnXyZZRqd25iYYPzZZk> M3[zfFEhdU1? NYD2eldDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF1KDFibV2gbY4heHKnc3XuZ4Uhd2ZiZ4Xhco9{cW6n MXOyN|k{Pzl5OR?=
human H1299 cells MUnGeY5kfGmxbjDhd5NigQ>? NVrlc3VJPyCmYYnz MkPwTY5pcWKrdHnvckBw\iCqdX3hckBWW1BzL2XBSlEhcW5iaIXtZY4hUDF{OUmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOxbH;ufUBnd3KvYYTpc44h[W[2ZYKgO{Bl[Xm|LDDFR|UxRTNizszN MV:yOVIzQTZ2Mx?=
human JEG3 cells M2nxTmZ2dmO2aX;uJIF{e2G7 MU\Jcohq[mm2aX;uJI9nKGG{b33heIF{\SCrbjDoeY1idiCMRVezJINmdGy|IHL5JJNkcW62aXzsZZRqd25ic4DlZ5Rzd22ndIL5MEBKSzVyPUCuNFAyPSEQvF2= NH:wc2gzODF2OEW2OC=>

... Click to View More Cell Line Experimental Data

In vivo Sodium butyrate significantly extends survival in a dose-dependent manner, improves body weight and motor performance, and delays the neuropathological sequelae in the R6/2 transgenic mouse model of Huntington's disease (HD). Sodium butyrate also increases histone and specificity protein-1 acetylation and protects against 3-nitropropionic acid neurotoxicity. [5]

Protocol

Solubility (25°C)

In vitro Water 22 mg/mL (199.83 mM)
Ethanol 22 mg/mL (199.83 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 110.09
Formula

C4H7NaO2

CAS No. 156-54-7
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03010865 Not yet recruiting Schizophrenic Disorder|Cognitive Impairment Shanghai Mental Health Center|Stanley Medical Research Institute February 2017 Phase 2|Phase 3
NCT02654405 Withdrawn Schizophrenic Disorders|Cognitive Function Nathan Kline Institute for Psychiatric Research|Stanley Medical Research Institute April 2016 Phase 2|Phase 3
NCT02271802 Completed SCFA Metabolism Maastricht University Medical Center|Top Institute Food and Nutrition June 2009 --
NCT00696098 Completed Gut Health Maastricht University Medical Center|Top Institute Food and Nutrition May 2007 --
NCT00693355 Completed Healthy Maastricht University|Top Institute Food and Nutrition|Maastricht University Medical Center December 2005 --
NCT00800930 Completed Shigellosis International Centre for Diarrhoeal Disease Research, Bangladesh|Swedish International Development Cooperation Agency (SIDA)|Karolinska Institutet January 2005 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Antibodies

HDAC Signaling Pathway Map

Related HDAC Products

Tags: buy Sodium butyrate | Sodium butyrate ic50 | Sodium butyrate price | Sodium butyrate cost | Sodium butyrate solubility dmso | Sodium butyrate purchase | Sodium butyrate manufacturer | Sodium butyrate research buy | Sodium butyrate order | Sodium butyrate mouse | Sodium butyrate chemical structure | Sodium butyrate mw | Sodium butyrate molecular weight | Sodium butyrate datasheet | Sodium butyrate supplier | Sodium butyrate in vitro | Sodium butyrate cell line | Sodium butyrate concentration | Sodium butyrate nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID