Catalog No.S7617 Synonyms: ABR-215050
Molecular Weight(MW): 406.36
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.
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|Description||Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.|
Tasquinimod inhibits tumor angiogenesis by allosteric inhibition of HDAC4/N-CoR/HDAC3 dependent deacetylation of HIF-1α.  Tasquinimod also targets infiltrating myeloid cells, and modulates local tumour immunity by blocking the interaction between S100A9 and its ligands receptor of advanced glycation end products and Toll-like receptor 4. 
|In vivo||Tasquinimod (30 mg/kg/d p.o.) shows anti-angiogenic activity and thus causes tumor growth inhibition in mice bearing human and rodent prostate cancer models. |
|In vitro||DMSO||81 mg/mL (199.33 mM)|
|Ethanol||11 mg/mL warmed (27.06 mM)|
|In vivo||5% DMSO+30% PEG 300+ddH2O||8mg/mL|
* 1 mg/ml means slightly soluble or insoluble.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02396368||Withdrawn||Prostate Cancer|Bone-only Metastatic Castration-Resistant Prostate Cancer (CRPC)||Sidney Kimmel Comprehensive Cancer Center||March 2015||Phase 1|
|NCT02159950||Completed||Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer||Roswell Park Cancer Institute|National Cancer Institute (NCI)|Active Biotech AB||January 2015||Phase 2|
|NCT02057666||Terminated||Asian Chemo-naïve Patients With Metastatic Castrate-resistant Prostate Cancer||Ipsen||January 2014||Phase 3|
|NCT01732549||Terminated||Metastatic Castrate Resistant Prostate Cancer||Ipsen||January 2013||Phase 2|
|NCT01743469||Active, not recruiting||Advanced or Metastatic Hepatocellular Cancer|Advanced or Metastatic Ovarian Cancer|Metastatic Renal Cell Cancer|Advanced or Metastatic Gastric Carcinoma||Ipsen||December 2012||Phase 2|
|NCT01513733||Completed||Prostate Cancer||Andrew J. Armstrong, MD|Duke University||January 2012||Phase 1|
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