Catalog No.S7617 Synonyms: ABR-215050
Molecular Weight(MW): 406.36
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.
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|Description||Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.|
Tasquinimod inhibits tumor angiogenesis by allosteric inhibition of HDAC4/N-CoR/HDAC3 dependent deacetylation of HIF-1α.  Tasquinimod also targets infiltrating myeloid cells, and modulates local tumour immunity by blocking the interaction between S100A9 and its ligands receptor of advanced glycation end products and Toll-like receptor 4. 
|In vivo||Tasquinimod (30 mg/kg/d p.o.) shows anti-angiogenic activity and thus causes tumor growth inhibition in mice bearing human and rodent prostate cancer models. |
|In vitro||DMSO||81 mg/mL (199.33 mM)|
|Ethanol||11 mg/mL warmed (27.06 mM)|
|In vivo||Add solvents individually and in order:
5% DMSO+30% PEG 300+ddH2O
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02396368||Withdrawn||Prostate Cancer|Bone-only Metastatic Castration-Resistant Prostate Cancer (CRPC)||Sidney Kimmel Comprehensive Cancer Center||March 2015||Phase 1|
|NCT02159950||Completed||Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer||Roswell Park Cancer Institute|National Cancer Institute (NCI)|Active Biotech AB||January 2015||Phase 2|
|NCT02057666||Terminated||Asian Chemo-naïve Patients With Metastatic Castrate-resistant Prostate Cancer||Ipsen||January 2014||Phase 3|
|NCT01732549||Terminated||Metastatic Castrate Resistant Prostate Cancer||Ipsen||January 2013||Phase 2|
|NCT01743469||Active, not recruiting||Advanced or Metastatic Hepatocellular Cancer|Advanced or Metastatic Ovarian Cancer|Metastatic Renal Cell Cancer|Advanced or Metastatic Gastric Carcinoma||Ipsen||December 2012||Phase 2|
|NCT01513733||Completed||Prostate Cancer||Andrew J. Armstrong, MD|Duke University||January 2012||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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