Cyclobenzaprine HCl

Catalog No.S4283

Cyclobenzaprine HCl is a muscle relaxant by blocking pain sensations, used for the treatment of muscle spasms.

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Cyclobenzaprine HCl Chemical Structure

Cyclobenzaprine HCl Chemical Structure
Molecular Weight: 311.85

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-06-25)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02642861 Not yet recruiting Liver Cirrhosis Tanta University January 2016 Phase 3
NCT02403687 Enrolling by invitation Arthritis|Tendonitis|Gout|Radiculopathy|Muscle Spasms|Synovitis|Migraine|Headache Express Specialty Pharmacy June 2015 --
NCT01921296 Terminated Sleep Initiation and Maintenance Disorders|Pain Lynn Henry|Damon Runyon Cancer Research Foundation|Univer  ...more Lynn Henry|Damon Runyon Cancer Research Foundation|University of Michigan Cancer Center August 2013 Phase 2
NCT01889173 Completed Healthy Adults Tonix Pharmaceuticals, Inc. June 2013 Phase 1
NCT01587508 Withdrawn Acute Lumbago Eurofarma Laboratorios S.A. May 2013 Phase 3

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Chemical Information

Download Cyclobenzaprine HCl SDF
Molecular Weight (MW) 311.85
Formula

C20H22ClN

CAS No. 6202-23-9
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 62 mg/mL (198.81 mM)
Water 62 mg/mL (198.81 mM)
Ethanol 62 mg/mL (198.81 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, hydrochloride (1:1)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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