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Sertraline HCl

Name: Sertraline HCl
Brand: Selleck Chemicals
SKU: S4053
Rating: 5 (3 reviews)

Synonyms: CP-51974-1 HCl

Catalog No.S4053 Purity: 99.97%

Sertraline HCl (CP-51974-1) is a 5-HT antagonist with K_i of 13 nM.

Sertraline HCl Chemical Structure

CAS: 79559-97-0

Selleck's Sertraline HCl has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.97%

99.97

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Biological Activity

Description

Sertraline HCl (CP-51974-1) is a 5-HT antagonist with K_i of 13 nM.

Targets

5-HT ^[1]

13 nM(Ki)

In vitro
In vitro	Sertraline exhibits better selectivity for inhibiting 5-HT uptake relative to NE uptake than fluvoxamine, zimelidine, norzimelidine, fluoxetine or chlorimipramine. However, Sertraline is less selective for blocking 5-HT uptake, relative to DA uptake than these agents. ^[1]

In Vivo
In vivo	Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline HCl strongly reduces immobility of mice in the Porsolt swim test for antidepressants. After repeated dosing in rats, sertraline HCl diminishes the cyclic AMP response of limbic forebrain adenylate cyclase to norepinephnne, as well as the binding of [³H]dihydroalprenolol to cortical membranes. ^[1]
Animal Research	Animal Models	Rats, Mice
	Dosages	--
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05730062	Not yet recruiting	Opioid Induced Respiratory Depression\|Depressive Disorder\|Anxiety Disorders	Leiden University Medical Center	March 15 2023	Phase 1
NCT05189977	Unknown status	Post-traumatic Stress Disorder (PTSD)	Otsuka Pharmaceutical Development & Commercialization Inc.\|Iqvia Pty Ltd	August 22 2022	Phase 1
NCT05210153	Recruiting	Depressive Disorder Major	University of Belgrade\|Clinical Centre of Serbia\|Institute of Mental Health Serbia\|Military Medical Academy Belgrade Serbia	July 16 2020	--
NCT04147000	Recruiting	Overweight\|Depression\|Anxiety Disorders	Linkoeping University\|Örebro University Sweden	January 1 2020	--
NCT03711708	Completed	Healthy	Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	November 6 2018	Phase 4

References

Chemical Information & Solubility

Molecular Weight	342.69	Formula	C₁₇H₁₇Cl₂N.HCl
CAS No.	79559-97-0	SDF	--
Smiles	CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 69 mg/mL ( (201.34 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 15 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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