Choose Your Country or Region

Ramosetron Hydrochloride

Name: Ramosetron Hydrochloride
Brand: Selleck Chemicals
SKU: S3723
Rating: 5 (1 reviews)

Synonyms: YM-060

Catalog No.S3723 Purity: 99.95%

Ramosetron Hydrochloride (YM-060) is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity.

Ramosetron Hydrochloride Chemical Structure

CAS: 132907-72-3

Selleck's Ramosetron Hydrochloride has been cited by 1 publication

Purity & Quality Control

Batch: S372301 DMSO] 63 mg/mL] false] Water] 63 mg/mL] false] Ethanol] 1 mg/mL] false Purity: 99.95%

99.95

Ramosetron Hydrochloride Related Products

Related Targets	5-HT1 5-HT2 5-HT3 5-HT4 5-HT6 5-HT7 5-HT5	Click to Expand
Related Products	Olanzapine Aripiprazole Puerarin Clozapine WAY-100635 Maleate Serotonin (5-HT) HCl Citalopram HBr Prucalopride BRL-15572 Dihydrochloride SB269970 HCl Trazodone Prucalopride Succinate Ketanserin RS-127445 Agomelatine (S20098) Risperidone Pimavanserin tartrate Azacyclonol Tegaserod Maleate Nuciferine Flopropione Vilazodone HCl SB742457 Almotriptan Malate BRL 15572 BRL-54443 Perospirone hydrochloride Alverine Citrate Cyproheptadine hydrochloride sesquihydrate Buspirone HCl Cisapride hydrate Alosetron Hydrochloride Loxapine Succinate Flibanserin Ondansetron Trazodone HCl SB 271046 hydrochloride Zolmitriptan PRX-08066 Maleic acid Thioridazine hydrochloride Blonanserin Vilazodone	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-alzheimer Disease Compound Library	Click to Expand

Signaling Pathway

5-HT Receptor Signaling Pathway

Choose Selective 5-HT Receptor Inhibitors

Biological Activity

Description

Ramosetron Hydrochloride (YM-060) is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity.

Targets

5-HT3 receptor ^[2]
(in N1E-15 cells)

0.091 nM(Ki)

In vitro
In vitro	Ramosetron Hydrochloride (YM-060) has very low afinity for nicotinic and GABA receptors. In vitro studies have also demonstrated that YM060 shows low afinity for 5-HT1-like, 5-HT2, alpha-1, atpha-2, beta-1, beta-2, histamine H1 and H2 receptors. YM-060 is expected not to have 5-HT4 receptor blocking activity^[2].

In Vivo
In vivo	Ramosetron is known to potently inhibit stress-induced abnormal defecation in animals. Ramosetron has potent, rapid-onset, and long-lasting inhibitory effects on CFS-induced defecation in rats, without any influence on normal defecation. The inhibitory effect of ramosetron appeared immediately after dosing and lasted for many hours^[1].
Animal Research	Animal Models	Sprague-Dawley rats
	Dosages	0.01, 0.03, 0.1 mg/kg
	Administration	oral

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01870895	Completed	Diarrhea-predominant Irritable Bowel Syndrome	Astellas Pharma Inc	February 2013	Phase 3
NCT01394653	Completed	Healthy\|Plasma Concentration of YM060	Astellas Pharma Inc	July 2011	Phase 1
NCT01392794	Completed	Healthy\|Plasma Concentration of YM060	Astellas Pharma Inc	April 2011	Phase 1

References

Chemical Information & Solubility

Molecular Weight	315.8	Formula	C₁₇H₁₇N₃O.HCl
CAS No.	132907-72-3	SDF	Download Ramosetron Hydrochloride SDF
Smiles	CN1C=C(C2=CC=CC=C21)C(=O)C3CCC4=C(C3)NC=N4.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 63 mg/mL ( (199.49 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 63 mg/mL

Ethanol : 1 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):