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Sodium ferulate 5-HT Receptor activator

Name: Sodium ferulate
Brand: Selleck Chemicals
SKU: S4740
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4740

Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.

Chemical Structure

Molecular Weight: 216.17

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Quality Control

Batch: Purity: 99.82%

99.82

Related Targets	Adrenergic Receptor AChR COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other 5-HT Receptor Inhibitors	WAY-100635 Maleate Puerarin Serotonin (5-HT) HCl SB269970 HCl Ketanserin BRL-15572 Dihydrochloride Nuciferine RS-127445 Flopropione Azacyclonol

Solubility

In vitro
Batch:

Water : 43 mg/mL

DMSO : 2 mg/mL (9.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	216.17	Formula	C₁₀H₉O₄.Na	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	24276-84-4	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Ferulic acid sodium salt			Smiles	COC1=C(C=CC(=C1)C=CC(=O)[O-])O.[Na+]

Mechanism of Action

In vitro	SF is stable, water soluble. In vitro, SF (0.4 mg/mL) inhibits platelet aggregation induced by adenosine diphosphate (ADP) or collagen. At 1 mg/mL SF inhibits thrombin-induced platelet aggregation and release of [3H]5-HT from labelled platelets. The mechanism of SF action appears to be mediated by inhibition of cyclooxygenase and TXA2 synthase. In vitro SF inhibits lipid peroxide malondialdehyde (MDA) production from the platelets of rats, inhibits haemolysis induced by MDA and hydroxyl radical (OH·), and in erythrocyte membranes it inhibits lipid peroxidation induced by hydrogen peroxide (H2O2) and superoxide anions (O₂^-). SF is a direct scavenger of oxygen free radicals. SF is found to act as a novel non-peptide endothelin antagonist and to prevent the binding of ET-1 to its receptor.
In vivo	SF has antithrombotic, platelet aggregation inhibitory and antioxidant activities in animals and humans. In ethanol, carbon tetrachloride-, paracetamol-, or prednisolone-induced liver toxicity in mice, SF, 0.1 g/kg intragastrically, daily for 10 days inhibits the rise of liver lipid peroxides MDA content and alleviates liver lesions by stabilizing glutathione (GSH) and related enzymes levels. In glycerol-induced renal oxidative injury in mice, SF at 0.2 g/kg i.p., reverses the increase of renal MDA content and the decrease of GSH content, glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), catalase (Cat), and SOD activities induced by glycerol injection, and improves renal histology. SF has a clear protective effect in experimental myocardial ischemia. In rabbits SF reduces the area of experimental myocardial infarction by 41% and decreases the oxygen consumption of guinea pig myocardial homogenates. SF has also a protective effect in myocardial ischemia reperfusion injury of rats. Furthermore, SF has an anti-atherogenetic effect in animal models. The antiarrhythmic effects of SF have been demonstrated in experimental animal models of arrhythmia, but not yet in clinical studies. The elimination half-life of SF is about 9.86 min. The acute oral LD50 of SF in mice is 3.2 g/kg.
References	[1] https://pubmed.ncbi.nlm.nih.gov/16007232/ [2] https://pubmed.ncbi.nlm.nih.gov/24489938/

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