Research Area
Product Type
United States ( Change Country )
Agomelatine Chemical Structure
Risperidone (Risperdal)
Risperidone(Risperdal) is an atypical antipsychotic used to treat schizophrenia.
WAY-100635
WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT
LY310762
LY310762 is a potent and selective 5-HT1D serotonin receptor antagonist with an EC50 of 31 nM.
BRL-15572
BRL-15572 is a hydrochloride salt form of BRL-15572 which is a selective serotonin receptor subtype 5-HT1D antagonist with an IC50 of 260 μM.
BMY 7378
BMY 7378 is a 5-HT1A receptor weak partial agonist/antagonist and α1D-adrenergic receptor antagonist with Ki values of 2.8 and 0.6 μM for cloned rat rat α1A and hamster α1B receptors, respectively.
RS-127445
RS-127445 is a potent, selective and high affinity serotonin 5-HT2B receptor antagonist with a pIC50 of 10.4.
LY2140023 (LY404039)
LY404039 is a potent agonist of recombinant human mGlu2, mGlu3 receptors and rat neurons expressing native mGlu2/3 receptors with Ki of 149 nM, 92 nM and 88nM, respectively.
Celecoxib
COX-2 inhibitor,IC50=0.04uM
BMS-708163
BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM)
Asenapine
Asenapine is a new atypical antipsychotic used for the treatment of schizophrenia and acute mania associated with bipolar disorder .
Biological Activity
Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. [1]
Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. [2]
References on Agomelatine
- [1] http://en.wikipedia.org/wiki/Agomelatine ;
- [2] Research Journal of Pharmaceutical, Biological and Chemical Sciences ;
Product Information
| Molecular Weight (WM): | 243.3 |
|---|---|
| Formula: | C15H17NO2 |
| CAS No.: | 138112-76-2 |
| Synonyms: |
Valdoxan, Melitor, Thymanax
|
| Dissolve in (25°C): | DMSO ≥49mg/mL |
| Water <1mg/mL | |
| Ethanol ≥49mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Keywords:buy Agomelatine | Agomelatine supplier | purchase Agomelatine | Agomelatine cost | Agomelatine manufacturer | order Agomelatine | Agomelatine distributor