Catalog No.S1243 Synonyms: S20098

Agomelatine Chemical Structure

Molecular Weight(MW): 243.3

Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
USD 470 In stock
USD 970 In stock
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Biological Activity

Description Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
5-HT2C [1]
In vitro

Agomelatine completely normalizes stress-affected cell survival and partly reverses reduced doublecortin expression in the hippocampus of rats subjected to chronic footshock stress. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK 293 M2nmOmZ2dmO2aX;uJIF{e2G7 MnPMRolv\GmwZzDh[oZqdmm2eTDmc5IhcHWvYX6gUYVt[XSxbnnuJJJm[2WydH;yJJR6eGViMVGgd5Ri[my7IITyZY5{\mWldHXkJIlvKGi3bXHuJIVu[nK7b37pZ{BscWSwZYmgZ4VtdHNiKFjFT{AzQTNrIIXzbY5oKDJvW{GyOWlecW:mb33lcIF1d26rbjDhd{Bz[WSrb3zp[4Fv\CxiS3m9OoUuODVizszN NH;zV2EyOjZ2NkCyNi=>
CHO cells M3LBfWZ2dmO2aX;uJIF{e2G7 M13uPVEzOCCvaX7z MVLEbZNxdGGlZX3lcpQhd2ZiW{GyOWlecW:mb33lcIF1d26rbjDmc5JuKGi3bXHuJG1VOSC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIFnfGW{IEGyNEBucW6|LDDLbV0xNjFibl2= M3[yO|IzOzBzMkG0
CHO-Galpha16 cells M{LQe2Z2dmO2aX;uJIF{e2G7 M3nKO|IxKG2rboO= NGD6fIpDcW6maX7nJIFn\mmwaYT5JJRwKHKjdDDNWFEhemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPIU{1I[WyyaHGxOkBk\WyuczDhd5Nme3OnZDDhd{BE[TJtIH3vZoltcXqjdHnvckBi\nSncjCyNEBucW6|IHL5JGZNUVCUIHHzd4F6NCCHQ{WwQVIvOSCwTR?= MU[yNVI{PzZ2NB?=

... Click to View More Cell Line Experimental Data

In vivo Agomelatine is effective in reversing the transgenic mouse behavioural changes noted in the Porsolt forced swim test as well as in the elevated plus maze. Agomelatine also markedly accelerates readjustment of circadian cycles of temperature and activity following an induced phase shift. [2] Agomelatine enhances cell proliferation and neurogenesis in the ventral hippocampus (VH) of adult rats, a region pertinent to mood disorders. Agomelatine increases the ratio of mature vs immature neurons and enhances neurite outgrowth of granular cells in adult rats, suggesting an acceleration of maturation. Agomelatine also activates several cellular signals (extracellular signal-regulated kinase1/2, protein kinase B, and glycogen synthase kinase 3beta) known to be modulated by antidepressants and implicated in the control of proliferation/survival. [3] Agomelatine enhances the time devoted to active social interaction in unfamiliar pairs of rats exposed to a novel environment. [4] Agomelatine increases cell proliferation and neurogenesis in the ventral dentate gyrus of rats, a region notably implicated in response to emotion, which is consistent with the antidepressant-anxiolytic properties of Agomelatine. Agomelatine increases survival of newly formed neurons in the entire dentate gyrus of rats. [5]


Solubility (25°C)

In vitro DMSO 48 mg/mL (197.28 mM)
Ethanol 48 mg/mL (197.28 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 243.3


CAS No. 138112-76-2
Storage powder
in solvent
Synonyms S20098

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02374567 Terminated Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Hannover Medical School January 2015 Phase 3
NCT01483053 Unknown status Major Depressive Disorder (MDD) Baker IDI Heart and Diabetes Institute|Servier Laboratories (Australia) Pty Ltd|The Alfred|Monash Medical Centre January 2014 Phase 4
NCT01822418 Completed Schizophrenia|Schizoaffective Disorder|Delusional Disorder Central Institute of Mental Health Mannheim|Servier January 2013 Phase 4
NCT01488071 Completed Major Depressive Disorder H. Lundbeck A/S January 2012 Phase 3
NCT01731899 Completed Major Depression|Fibromyalgia Universidad de Granada June 2010 --
NCT01108393 Completed Obsessive Compulsive Disorder Servier May 2010 Phase 2

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID