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Serotonin (5-HT) HCl

Name: Serotonin (5-HT) HCl
Brand: Selleck Chemicals
SKU: S4244
Rating: 5 (7 reviews)

Catalog No.S4244 Purity: 99.95%

Serotonin (5-HT) HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

Serotonin (5-HT) HCl Chemical Structure

CAS: 153-98-0

Selleck's Serotonin (5-HT) HCl has been cited by 7 publications

Purity & Quality Control

Batch: Purity: 99.95%

99.95

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Signaling Pathway

5-HT Receptor Signaling Pathway

Choose Selective 5-HT Receptor Inhibitors

Biological Activity

Description

Serotonin (5-HT) HCl is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.

Targets

5-HT ^[1]

In vitro
In vitro	Serotonin stimulates acid–base transport by the anterior stomach region of the midgut in vitro. The function of this stimulation is assumed to be maintenance of optimal conditions for digestion and absorption of nutrients rather than regulation of hemolymph acid–base homeostasis. ^[1]
Experimental Result Images	Methods	Biomarkers	Images	PMID
	Western blot	FAS / L-FABP1 / pS79-ACC / ACC / SREBP1 / SCD1 / pPPARα / PPAR-γ LC3β / ATG3 / pS65-4EBP1 / Beclin-1 / SIRT1 / p62 / FOXO3a		30409162
	Growth inhibition assay	Cell proliferation		30409162

In Vivo
In vivo	The role of serotonin in the regulation of larval Aedes aegypti hemolymph composition is investigated in vivo using two reuptake inhibitors (SSRIs), alaproclate HCl and 6-nitroquipazine maleate, and the receptor antagonist methiothepin mesylate. ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06056258	Recruiting	Mood and Sleep Quality	Vedic Lifesciences Pvt. Ltd.	December 4 2023	Not Applicable
NCT05953038	Recruiting	Basic Science	Rigshospitalet Denmark	November 8 2023	Early Phase 1
NCT06081348	Not yet recruiting	Neurodevelopmental Disorders\|Autism\|Autism Spectrum Disorder\|Fragile X Syndrome\|Tuberous Sclerosis\|22Q11 Deletion Syndrome\|22Q11 Deletion\|ADHD\|Tic Disorders\|Tourette Syndrome\|Tourette Syndrome in Children\|Tourette Syndrome in Adolescence\|ADHD - Combined Type\|ADHD Predominantly Inattentive Type\|ADHD Predominantly Hyperactive - Impulsive\|Provisional Tic Disorder\|Anxiety\|Anxiety Disorders\|Agoraphobia\|Generalized Anxiety\|Generalized Anxiety Disorder\|Social Anxiety\|Social Anxiety Disorder\|Unspecified Anxiety Disorder\|Other Specified Anxiety Disorders\|Separation Anxiety	Anagnostou Evdokia M.D.\|Azrieli Foundation\|Canadian Institutes of Health Research (CIHR)\|Ontario Brain Institute\|Holland Bloorview Kids Rehabilitation Hospital\|McMaster University\|Western University\|Queen''s University\|University of Alberta\|Alberta Health services\|St. Justine''s Hospital\|Dalhousie University\|Unity Health Toronto\|University of Toronto\|The Hospital for Sick Children	October 2023	Phase 2

References

[1] Onken, H, et al. J Insect Sci, 2008, 8, 1-20.

Chemical Information & Solubility

Molecular Weight	212.68	Formula	C₁₀H₁₂N₂O.HCl
CAS No.	153-98-0	SDF	Download Serotonin (5-HT) HCl SDF
Smiles	C1=CC2=C(C=C1O)C(=CN2)CCN.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 43 mg/mL ( (202.18 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 43 mg/mL

Ethanol : 43 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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