Mirtazapine

Catalog No.S2016 Synonyms: Org3770

Mirtazapine Chemical Structure

Molecular Weight(MW): 265.35

Mirtazapine is an adrenergic and seroton receptor antagonist, used to treat depression.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 270 In stock
USD 570 In stock
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Biological Activity

Description Mirtazapine is an adrenergic and seroton receptor antagonist, used to treat depression.
Targets
5-HT [1]
In vitro

Mirtazapine displays marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocks noradrenaline (NA)-induced stimulation of guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Mirtazapine shows high affinity for cloned, human serotonin (5-HT)2C receptors at which it abolishes 5-HT-induced phosphoinositide generation. Mirtazapine markedly elevates dialysate levels of NA and, in FCX, DA, whereas 5-HT is not affected.[1] Mirtazapine enhances the effectiveness of the electrical stimulation of the ascending 5-HT pathway by blocking both alpha-2 adrenergic auto- and heteroreceptors. Mirtazapine blocks the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors. [2]

In vivo Mirtazapine (10-250 mg/kg i.v.) enhances dose-dependently the firing activity of the 5-HT neurons in naive rats, but not in 6-hydroxydopamine-pretreated rats. [2] Mirtazapine (5 mg/kg/day, s.c., using osmotic minipumps) increases the spontaneous firing activity of locus coeruleus noradrenaline (NA) neurons in male Sprague-Dawley rats. Mirtazapine antagonizes both the enhancing effect of a low dose (10 mg/kg, i.v.) and the reducing effect of a high dose (100 mg/kg, i.v.) of the alpha 2-adrenoceptor agonist clonidine on the effectiveness of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of dorsal hippocampus CA3 pyramidal neurons. [3] Mirtazapine (5 mg/kg s.c.) only slightly affects DOPAC and homovanillic acid levels in the striatum, hardly affects 5-HT release in freely moving rats, but clearly increased 5-hydroxyindole acetic acid. [4]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (199.73 mM)
Ethanol 53 mg/mL (199.73 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 265.35
Formula

C17H19N3

CAS No. 85650-52-8
Storage powder
Synonyms Org3770

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03031184 Recruiting Dementia University of Sussex|Norwich Clinical Trials Unit|University of East Anglia|University of Cambridge|University College, London|London School of Economics and Political Science|University of Manchester|University of Newcastle Upon-Tyne|Birmingham and Solihull Mental Health NHS Foundation Trust|Alzheimers Society|The Centre for Dementia Studies, Brighton and Sussex Medical School and SPFT January 2017 Phase 3
NCT02650544 Active, not recruiting Carcinoma, Non-Small-Cell Lung|Depression Sun Yat-sen University December 2015 Phase 2
NCT02809677 Recruiting Asthma: [Nos] or [Attack]|Major Depressive Disorder University of Texas Southwestern Medical Center|National Heart, Lung, and Blood Institute (NHLBI)|University at Buffalo December 2015 Phase 4
NCT02655354 Recruiting Posttraumatic Stress Disorder|Depression|Alcohol-Related Disorders|Suicidal Ideation|Substance-Related Disorders|Mild Cognitive Impairment|Quality of Life|Pain|Wounds and Injury|Brain Injuries|Chronic Disease University of Washington|National Institutes of Health (NIH) October 2015 --
NCT02646449 Recruiting Major Depressive Disorder|Alcohol Use Disorder University of Pittsburgh June 2015 Phase 2
NCT02711215 Recruiting Major Depressive Disorder Medical University of Vienna May 2015 Phase 4

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID