ML167

Catalog No.S7509 Synonyms: CID 44968231

ML167 Chemical Structure

Molecular Weight(MW): 335.36

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.

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Biological Activity

Description ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
Targets
CLK4 [1] CLK1 [1] CLK2 [1] Dyrk1B [1]
136 nM 1522 nM 1648 nM 4420 nM
In vitro

ML167, as a probe of Clk4, shows high cell permeability in a Caco-2 assay. [1]

Protocol

Solubility (25°C)

In vitro DMSO 67 mg/mL (199.78 mM)
Ethanol 13 mg/mL warmed (38.76 mM)
Water slightly soluble or insoluble
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 335.36
Formula

C19H17N3O3

CAS No. 1285702-20-6
Storage powder
in solvent
Synonyms CID 44968231

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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CDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID