DHFR

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DHFR Inhibitors (6)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1135 Pemetrexed Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
  • Cancer Res, 2014, 74(21):5948-54
  • Mol Cancer Res, 2013, 12(12):2675-84
  • Biochem Biophys Res Commun, 2014, 452(1):72-8
S1210 Methotrexate Methotrexate is an antimetabolite and antifolate drug, which acts by inhibiting the metabolism of folic acid.
  • Biochem Pharmacol, 2015, 93(3):305-17
S1497 Pralatrexate Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
S2006 Pyrimethamine Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.
S1618 Sulfameter Sulfameter is a long-acting sulfonamide antibacterial.
S7785 Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1135 Pemetrexed 94 mg/mL <1 mg/mL <1 mg/mL
S1210 Methotrexate <1 mg/mL 90 mg/mL <1 mg/mL
S1497 Pralatrexate <1 mg/mL 28 mg/mL <1 mg/mL
S2006 Pyrimethamine <1 mg/mL 10 mg/mL <1 mg/mL
S1618 Sulfameter <1 mg/mL 56 mg/mL <1 mg/mL
S7785 Pemetrexed Disodium Hydrate 100 mg/mL <1 mg/mL <1 mg/mL
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