DHFR

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DHFR Inhibitors (4)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1135 Pemetrexed Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
  • Cancer Res, 2014, 10.1158/0008-5472.CAN-14-0809
  • Mol Cancer Res, 2013, 12(12):2675-84
  • Biochem Biophys Res Commun, 2014, 452(1):72-8
S1210 Methotrexate Methotrexate is an antimetabolite and antifolate drug, which acts by inhibiting the metabolism of folic acid.
S1497 Pralatrexate Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
S2006 Pyrimethamine Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.
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