Rho

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1314 Zoledronic Acid <1 mg/mL 0.004 mg/mL <1 mg/mL
S8031 NSC 23766 100 mg/mL 100 mg/mL <1 mg/mL
S7319 EHop-016 <1 mg/mL 86 mg/mL <1 mg/mL
S1721 Azathioprine <1 mg/mL 54 mg/mL <1 mg/mL
S7293 ZCL278 <1 mg/mL 100 mg/mL <1 mg/mL
S8499 KRpep-2d 100 mg/mL -1 mg/mL -1 mg/mL
S8156 ARS-853 (ARS853) <1 mg/mL 86 mg/mL 1 mg/mL
S7332 K-Ras(G12C) inhibitor 9 <1 mg/mL 53 mg/mL <1 mg/mL
S7719 CCG-1423 <1 mg/mL 90 mg/mL 4 mg/mL
S7330 6H05 100 mg/mL 100 mg/mL 100 mg/mL
S7331 K-Ras(G12C) inhibitor 12 <1 mg/mL 27 mg/mL <1 mg/mL
S8303 Kobe0065 <1 mg/mL 89 mg/mL 13 mg/mL
S7333 K-Ras(G12C) inhibitor 6 <1 mg/mL 81 mg/mL 30 mg/mL
S7607 BQU57 <1 mg/mL 66 mg/mL 20 mg/mL
S7482 EHT 1864 2HCl 100 mg/mL 100 mg/mL <1 mg/mL
S7686 ML141 <1 mg/mL 81 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S1314

Zoledronic Acid

Zoledronic acid (ZA), a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.

S8031

NSC 23766

NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.

S7319

EHop-016

EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.

S1721

Azathioprine

Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.

S7293

ZCL278

ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.

S8499New

KRpep-2d

KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM.

S8156New

ARS-853 (ARS853)

ARS-853 is a selective, covalent inhibitor of KRAS(G12C) that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

S7332

K-Ras(G12C) inhibitor 9

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).

S7684

Salirasib

Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.

S7719

CCG-1423

CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.

S7330

6H05

6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).

S7331

K-Ras(G12C) inhibitor 12

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).

S8303

Kobe0065

Kobe0065 is H-Ras-cRaf1 interaction inhibitor, exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.

S7333

K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C).

S7607

BQU57

BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.

S7482

EHT 1864 2HCl

EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.

S7686

ML141

ML141 (CID-2950007), is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7).