Rho

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Rho Inhibitors (13)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1314 Zoledronic Acid Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
  • Liver Int, 2013, 33(1):127-36
  • Osteoporos Int, 2014, 25(7):1975-81
S8031 NSC 23766 NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
  • Cancer Lett, 2016, 10.1016/j.canlet.2016.02.049
  • Sci Rep, 2016, 10.1038/srep22363
  • Cell Death Dis, 2015, 6:e1751
S7319 EHop-016 EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.
  • Cell Death Dis, 2015, 6:e1751
S1721 Azathioprine Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.
S7293 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
  • Cell Physiol Biochem, 2015, 36(4):1613-1627
S7333 K-Ras(G12C) inhibitor 6 K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C).
S7482 EHT 1864 EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
S7332 K-Ras(G12C) inhibitor 9 K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
S7330 6H05 6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).
S7331 K-Ras(G12C) inhibitor 12 K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S7686 ML141 ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
S7684 Salirasib Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.
S7719 CCG-1423 CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.
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All Rho Products

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1314 Zoledronic Acid <1 mg/mL 0.004 mg/mL <1 mg/mL
S8031 NSC 23766 100 mg/mL 100 mg/mL <1 mg/mL
S7319 EHop-016 <1 mg/mL 86 mg/mL <1 mg/mL
S1721 Azathioprine <1 mg/mL 54 mg/mL <1 mg/mL
S7293 ZCL278 <1 mg/mL 100 mg/mL <1 mg/mL
S7333 K-Ras(G12C) inhibitor 6 <1 mg/mL 81 mg/mL 30 mg/mL
S7482 EHT 1864 100 mg/mL 100 mg/mL <1 mg/mL
S7332 K-Ras(G12C) inhibitor 9 <1 mg/mL 53 mg/mL <1 mg/mL
S7330 6H05 100 mg/mL 100 mg/mL 100 mg/mL
S7331 K-Ras(G12C) inhibitor 12 <1 mg/mL 27 mg/mL <1 mg/mL
S7686 ML141 <1 mg/mL 81 mg/mL <1 mg/mL
S7719 CCG-1423 <1 mg/mL 90 mg/mL 4 mg/mL
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