Microtubule Associated

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1150 Paclitaxel <1 mg/mL 171 mg/mL 18 mg/mL
S1148 Docetaxel <1 mg/mL 100 mg/mL 53 mg/mL
S1241 Vincristine sulfate 60 mg/mL 100 mg/mL <1 mg/mL
S1364 Patupilone (EPO906, Epothilone B) <1 mg/mL 102 mg/mL 102 mg/mL
S1165 ABT-751 (E7010) <1 mg/mL 74 mg/mL 12 mg/mL
S2775 Nocodazole <1 mg/mL 7 mg/mL <1 mg/mL
S3022 Cabazitaxel <1 mg/mL 100 mg/mL <1 mg/mL
S1248 Vinblastine <1 mg/mL 68 mg/mL 6 mg/mL
S2195 Lexibulin (CYT997) <1 mg/mL 86 mg/mL 20 mg/mL
S1297 Epothilone A <1 mg/mL 99 mg/mL 99 mg/mL
S7204 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 28 mg/mL <1 mg/mL <1 mg/mL
S1640 Albendazole <1 mg/mL 17 mg/mL <1 mg/mL
S2209 Vinflunine Tartrate 66 mg/mL 100 mg/mL 11 mg/mL
S7336 CW069 <1 mg/mL 100 mg/mL 4 mg/mL
S1836 Albendazole Oxide <1 mg/mL 11 mg/mL <1 mg/mL
S7721 Monomethyl auristatin E (MMAE) <1 mg/mL 100 mg/mL 100 mg/mL
S4114 Triclabendazole <1 mg/mL 72 mg/mL <1 mg/mL
S7787 Docetaxel Trihydrate <1 mg/mL 100 mg/mL 100 mg/mL
S7783 Combretastatin A4 <1 mg/mL 63 mg/mL 34 mg/mL
S4071 Griseofulvin <1 mg/mL 50 mg/mL <1 mg/mL
S7762 TRx0237 (LMTX) mesylate 95 mg/mL 95 mg/mL <1 mg/mL
S7497 CK-636 <1 mg/mL 57 mg/mL 50 mg/mL
S4269 Vinorelbine Tartrate 100 mg/mL 100 mg/mL 100 mg/mL
S7495 TAI-1 <1 mg/mL 86 mg/mL <1 mg/mL
S7930 Ixabepilone (BMS-247550) <1 mg/mL 100 mg/mL 100 mg/mL
S4505 Vinblastine sulfate <1 mg/mL 100 mg/mL <1 mg/mL
S7493 INH1 <1 mg/mL 61 mg/mL 61 mg/mL
S7494 INH6 <1 mg/mL 64 mg/mL 11 mg/mL
Catalog No. Information Product Use Citations Product Validations
S1150

Paclitaxel

Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

S1148

Docetaxel

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

S1241

Vincristine sulfate

Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.

S1364

Patupilone (EPO906, Epothilone B)

Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.

S1165

ABT-751 (E7010)

ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.

S2775

Nocodazole

Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.

S3022

Cabazitaxel

Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide.

S1248

Vinblastine

Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

S2195

Lexibulin (CYT997)

Lexibulin (CYT997) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.

S1297

Epothilone A

Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.

S7204

Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium

Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Phase 3.

S1640

Albendazole

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

S2209

Vinflunine Tartrate

Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. Phase 3.

S7336

CW069

CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.

S1836

Albendazole Oxide

Albendazole is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.

S7721

Monomethyl auristatin E (MMAE)

Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .

S4114

Triclabendazole

Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.

S7787

Docetaxel Trihydrate

Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

S7783

Combretastatin A4

Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.

S4071

Griseofulvin

Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.

S7762

TRx0237 (LMTX) mesylate

TRx 0237 (LMTX™) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

S7497

CK-636

CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.

S4269

Vinorelbine Tartrate

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

S7495

TAI-1

TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.

S7930

Ixabepilone (BMS-247550)

Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.

S4505

Vinblastine sulfate

Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

S7493

INH1

INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.

S7494

INH6

INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.

Catalog No. Information Product Use Citations Product Validations
A5032New

Beta Tubulin Rabbit Recombinant mAb

Tags: microtubule inhibition | microtubule drugs | microtubule cancer | microtubule assay | microtubule phosphorylation | tubulin pathway | microtubule poison | microtubule inhibitors cancer | microtubule inhibitor drugs | microtubule inhibitor review