Casein Kinase

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2248 Silmitasertib (CX-4945) <1 mg/mL 16 mg/mL <1 mg/mL
S5265 TBB -1 mg/mL 86 mg/mL -1 mg/mL
S7642 D 4476 <1 mg/mL 79 mg/mL <1 mg/mL
S8237 IC261 <1 mg/mL 62 mg/mL <1 mg/mL
S5516 Ellagic Acid hydrate -1 mg/mL 2 mg/mL -1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S2248

Silmitasertib (CX-4945)

Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2.

S5265New

TBB

TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.

S7642

D 4476

D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.

S8237

IC261

IC261 is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.

S5516New

Ellagic Acid hydrate

Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.