Casein Kinase

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2248 Silmitasertib (CX-4945) <1 mg/mL 16 mg/mL <1 mg/mL
S7642 D 4476 <1 mg/mL 79 mg/mL <1 mg/mL
S8237 IC261 <1 mg/mL 62 mg/mL <1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S2248

Silmitasertib (CX-4945)

Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2.

S7642

D 4476

D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.

S8237

IC261

IC261 is a novel inhibitor of CK1. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.