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Chk Checkpoint Kinase

Compare Chk Inhibitors

Compare Chk Inhibitors

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1532	AZD7762	<1 mg/mL	50 mg/mL	<1 mg/mL
S2626	LY2603618 (IC-83)	<1 mg/mL	13 mg/mL	<1 mg/mL
S2683	CHIR-124	<1 mg/mL	7 mg/mL	<1 mg/mL
S2735	SCH 900776	<1 mg/mL	60 mg/mL	3 mg/mL
S2904	PF 477736	<1 mg/mL	6 mg/mL	<1 mg/mL

Research Area
Research Area

Chk Inhibitors (5)
water-soluble

Cat.No.	Product Name	Information	Product Citations	Customer Reviews
S1532	AZD7762	AZD7762 is a novel CHK1 and CHK2 inhibitor with IC50 of 5 nM and <10 nM, respectively.	Nat Biotechnol, 2011, 29(6):542-6 PLoS ONE, 2010, 5(12), e14335 PLoS One, 2013, 8(2):e55493
S2626	LY2603618 (IC-83)	LY2603618 (IC-83) is a selective Chk1 inhibitor with potential anti-tumor activity.
S2683	CHIR-124	CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM.
S2735	SCH 900776	SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM and also inhibits CDK2 with IC50 of 160 nM.
S2904	PF 477736	PF 477736 is a ChK inhibitor against ChK1, ChK2, VEGFR2, Yes and Fms with IC50 of 0.49 nM, 47 nM, 8 nM, 14 nM and 10 nM, respectively.

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1532	AZD7762	<1 mg/mL	50 mg/mL	<1 mg/mL
S2626	LY2603618 (IC-83)	<1 mg/mL	13 mg/mL	<1 mg/mL
S2683	CHIR-124	<1 mg/mL	7 mg/mL	<1 mg/mL
S2735	SCH 900776	<1 mg/mL	60 mg/mL	3 mg/mL
S2904	PF 477736	<1 mg/mL	6 mg/mL	<1 mg/mL

Tags: Checkpoint activation | Checkpoint kinase | Checkpoint function | Checkpoint activity | Chk1 phosphorylation | Checkpoint pathway | Chk1 pathway | Chk2 pathway | Chk2 phosphorylation | Chk1 inhibitor clinical trial | Chk1 inhibition | Chk1 activation | Chk2 activation | Chk1 assay | Chk inhibitors review