Product Categories

5-HT Receptor Antagonists & Agonists

5-HT Receptor Antagonists & Agonists (52)
water-soluble

Cat.No.	Product Name	Information
S2232	Ketanserin (Vulketan Gel)	Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.
S1333	Fluoxetine HCl	Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class.
S2493	Olanzapine (Zyprexa)	Olanzapine(Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
S1441	Venlafaxine	Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI).
S1615	Risperidone (Risperdal)	Risperidone(Risperdal) is an atypical antipsychotic used to treat schizophrenia.
S4109	Lorcaserin HCl	Lorcaserin HCl is a selective full agonist of human 5-HT2C receptor with K_i of 15 nM.
S4112	Desvenlafaxine Succinate	Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with K_i of 40.2 nM and 558.4 nM respectively.
S4113	Desvenlafaxine	Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K_i of 40.2 nM and 558.4 nM, respectively.
S4053	Sertraline HCl	Sertraline HCl is a 5-HT antagonist with K_i of 13 nM.
S8021	Vortioxetine (Lu AA21004) hydrobromide	Lu-AA21004 is an oral multimodal serotonergic agent, inhibits 5-HT(1A), 5-HT(1B), 5-HT(3A), 5-HT(7) and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
S2459	Clozapine (Clozaril)	Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.
S1283	Asenapine	Asenapine ihibits adrenergic receptor (α₁, α_2A, α_2B, α_2C) with K_i of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with K_i of 0.03-4.0 nM.
S8010	PRX-08066	PRX-08066 is a selective 5-HT2B antagonist with IC50 of 3.4 nM.
S2875	Prucalopride	Prucalopride is a selective, high affinity 5-HT receptor agonistfor 5-HT4a and 5-HT4b with K_i of 2.5 nM and 8 nM, respectively.
S2865	VUF 10166	VUF10166 is a novel, potent and competitive antagonist to 5-HT₃A with K_i of 0.04 nM.
S3005	Paroxetine HCl	Paroxetine is an antidepressant drug of the SSRI type.
S2106	Azasetron HCl (Y-25130)	Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
S2096	Almotriptan malate (Axert)	Almotriptan malate (Axert) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
S2112	Blonanserin (Lonasen)	Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties.
S2084	Duloxetine HCl (Cymbalta)	Duloxetine is a serotonin-norepinephrine reuptake inhibitor with K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
S1975	Aripiprazole (Abilify)	Aripiprazole is a human 5-HT_1A receptor partial agonist with a K_i of 4.2 nM.
S2025	Urapidil HCl	Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.
S2582	Trazodone HCl (Desyrel)	Trazodone is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
S2698	RS-127445	RS-127445 is a selective 5-HT2B antagonist with pK_i of 9.5 and pIC50 of 10.4.
S1996	Ondansetron (Zofran)	Ondansetron (Zofran) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
S2856	SB 271046	SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pK_i of 8.9.
S2894	SB-742457	SB-742457 is a highly selective 5-HT6 receptor antagonist with pK_i of 9.63.
S3050	Palonosetron HCl	Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
S2849	SB-269970 HCl	SB-269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT₇ receptor antagonist with pK_i of 8.3.
S2852	BRL 54443	BRL 54443 is a 5-HT_1E and 5-HT_1F receptor agonist with pK_i of 8.7 and 9.25, respectively.
S2677	BRL-15572	BRL-15572 is a 5-HT_1D antagonist with pK_i of 7.9.
S2669	LY310762	LY310762 is a 5-HT_1D antagonist with K_i of ~0.2 μM.
S2860	IEM 1754 Dihydrobromide	IEM 1754 dihydrobroMide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
S3175	Atomoxetine HCl
S3180	Eletriptan HBr	Eletriptan is a selective 5-HT1B and 5-HT1D receptor agonist with K_i of 0.92 nM and 3.14 nM, respectively.
S3183	Amitriptyline HCl	Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.
S2663	WAY-100635 HCl	WAY 100635 is a potent and selective 5-HT agonist with IC50 of 0.95 nM.
S2691	BMY 7378	BMY 7378 is a multiple inhibitors of α_2C-adrenoceptor and α_1D-adrenoceptor with pK_i of 6.54 and 8.2, respectively.
S2541	Clomipramine HCl (Anafranil)	Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
S1869	Dapoxetine HCl (Priligy)	Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor.
S1898	Tropisetron	Tropisetron hydrochloride is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
S1649	Zolmitriptan (Zomig)	Zolmitriptan(Zomig) is a selective serotonin receptor agonist.
S1607	Rizatriptan Benzoate (Maxalt)	Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.
S1488	Naratriptan HCl	Naratriptan (Amerge) is a triptan agent that is used for the treatment of migraine headaches.
S1432	Sumatriptan succinate	Sumatriptan succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
S1436	Tianeptine sodium	Tianeptine is a selective serotonin reuptake enhancer (SSRE) compound used for treating major depressive episodes.
S1385	Mosapride citrate	Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
S1390	Ondansetron HCl (Zofran)	Ondansetron is a serotonin 5-HT3 receptor antagonist.
S1336	Fluvoxamine maleate	Fluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI).
S1345	Granisetron HCl	Granisetron HCl is a serotonin 5-HT3 receptor antagonist
S1243	Agomelatine	Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
S1245	Dimebon (Latrepirdine)	Dimebon is an antihistamine drug.

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S2232	Ketanserin (Vulketan Gel)	<1 mg/mL	2 mg/mL	<1 mg/mL
S1333	Fluoxetine HCl	4 mg/mL	69 mg/mL	69 mg/mL
S2493	Olanzapine (Zyprexa)	<1 mg/mL	63 mg/mL	9 mg/mL
S1441	Venlafaxine	55.5 mg/mL	55.5 mg/mL	55.5 mg/mL
S1615	Risperidone (Risperdal)	<1 mg/mL	3 mg/mL	4 mg/mL
S4112	Desvenlafaxine Succinate	<1 mg/mL	80 mg/mL	<1 mg/mL
S4113	Desvenlafaxine	<1 mg/mL	37 mg/mL	3 mg/mL
S4053	Sertraline HCl	<1 mg/mL	69 mg/mL	15 mg/mL
S8021	Vortioxetine (Lu AA21004) hydrobromide	<1 mg/mL	76 mg/mL	17 mg/mL
S2459	Clozapine (Clozaril)	<1 mg/mL	65 mg/mL	32 mg/mL
S1283	Asenapine	<1 mg/mL	80 mg/mL	<1 mg/mL
S8010	PRX-08066	104 mg/mL	104 mg/mL	98 mg/mL
S2875	Prucalopride	<1 mg/mL	60 mg/mL	38 mg/mL
S2865	VUF 10166	<1 mg/mL	21 mg/mL	61 mg/mL
S3005	Paroxetine HCl	10 mg/mL	73 mg/mL	35 mg/mL
S2106	Azasetron HCl (Y-25130)	3 mg/mL	<1 mg/mL	<1 mg/mL
S2096	Almotriptan malate (Axert)	<1 mg/mL	94 mg/mL	53 mg/mL
S2112	Blonanserin (Lonasen)	<1 mg/mL	<1 mg/mL	<1 mg/mL
S2084	Duloxetine HCl (Cymbalta)	<1 mg/mL	67 mg/mL	<1 mg/mL
S1975	Aripiprazole (Abilify)	<1 mg/mL	90 mg/mL	<1 mg/mL
S2025	Urapidil HCl	85 mg/mL	24 mg/mL	1 mg/mL
S2582	Trazodone HCl (Desyrel)	<1 mg/mL	1 mg/mL	<1 mg/mL
S2698	RS-127445	<1 mg/mL	56 mg/mL	8 mg/mL
S1996	Ondansetron (Zofran)	<1 mg/mL	0.1 mg/mL	<1 mg/mL
S2856	SB 271046	<1 mg/mL	40 mg/mL	<1 mg/mL
S2894	SB-742457	<1 mg/mL	78 mg/mL	2 mg/mL
S3050	Palonosetron HCl	67 mg/mL	<1 mg/mL	<1 mg/mL
S2849	SB-269970 HCl	<1 mg/mL	11 mg/mL	<1 mg/mL
S2852	BRL 54443	<1 mg/mL	46 mg/mL	2 mg/mL
S2677	BRL-15572	<1 mg/mL	96 mg/mL	40 mg/mL
S2669	LY310762	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S2860	IEM 1754 Dihydrobromide	82 mg/mL	82 mg/mL	<1 mg/mL
S3175	Atomoxetine HCl	2 mg/mL	58 mg/mL	37 mg/mL
S3183	Amitriptyline HCl	15 mg/mL	63 mg/mL	63 mg/mL
S2663	WAY-100635 HCl	<1 mg/mL	85 mg/mL	85 mg/mL
S2691	BMY 7378	92 mg/mL	92 mg/mL	20 mg/mL
S2541	Clomipramine HCl (Anafranil)	70 mg/mL	70 mg/mL	70 mg/mL
S1869	Dapoxetine HCl (Priligy)	68 mg/mL	68 mg/mL	68 mg/mL
S1898	Tropisetron	64 mg/mL	35 mg/mL	<1 mg/mL
S1649	Zolmitriptan (Zomig)	<1 mg/mL	58 mg/mL	58 mg/mL
S1607	Rizatriptan Benzoate (Maxalt)	46 mg/mL	20 mg/mL	<1 mg/mL
S1488	Naratriptan HCl	22 mg/mL	74 mg/mL	<1 mg/mL
S1432	Sumatriptan succinate	83 mg/mL	83 mg/mL	<1 mg/mL
S1436	Tianeptine sodium	92 mg/mL	92 mg/mL	92 mg/mL
S1385	Mosapride citrate	<1 mg/mL	90 mg/mL	<1 mg/mL
S1390	Ondansetron HCl (Zofran)	24 mg/mL	66 mg/mL	10 mg/mL
S1336	Fluvoxamine maleate	<1 mg/mL	87 mg/mL	87 mg/mL
S1345	Granisetron HCl	70 mg/mL	1 mg/mL	1 mg/mL
S1243	Agomelatine	<1 mg/mL	49 mg/mL	49 mg/mL
S1245	Dimebon (Latrepirdine)	79 mg/mL	24 mg/mL	13 mg/mL

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5-HT Receptor Antagonists & Agonists

5-HT Receptor Antagonists & Agonists (52)water-soluble

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5-HT Receptor Antagonists & Agonists (52)
water-soluble