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P450 (e.g. CYP17) Cytochrome P450

P450 (e.g. CYP17) Inhibitors (17)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S2246 Abiraterone Acetate (CB7630) Abiraterone acetate (CB7630, CB 7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM.
S1190 Bicalutamide (Casodex) Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM.
S1123 Abiraterone (CB-7598) Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM.
S2187 Avasimibe(CI-1011) Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively.
S1442 Voriconazole Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.
S2921 PF-4981517 PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM.
S2900 Cobicistat (GS-9350) Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
S1250 MDV3100 (Enzalutamide) MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM.
S1353 Ketoconazole Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively.
S1908 Flutamide (Eulexin) Flutamide (Eulexin) is an oral nonsteroidal antiandrogen agent primarily used to treat prostate cancer.
Cat.No. Product Name Information Product Citations Customer Reviews
S2555 Clarithromycin (Biaxin, Klacid) Clarithromycin (Biaxin, Klacid) is a macrolide antibiotic and a CYP3A4 substrate and inhibitor.
S2042 Cyproterone acetate Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM.
S2757 TH-302 TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM.
S2803 Galeterone (TOK-001) Galeterone (TOK-001, VN/124-1) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively.
S1195 TAK-700 (Orteronel) TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively.
S2526 Alizarin Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively.
S2046 Pioglitazone HCl (Actos) Pioglitazone hydrochloride (Actos) is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively.
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All P450 (e.g. CYP17) Inhibitors
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