Chlorzoxazone

Catalog No.S4155

Chlorzoxazone Chemical Structure

Molecular Weight(MW): 169.57

Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.

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Biological Activity

Description Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
In vitro

Chlorzoxazone is well documented to be metabolized mainly to 6-hydroxychlorzoxazone physically, which is catalyzed primarily by CYP2E1. Other human hepatic P450 enzymes, namely CYP1A1, CYP1A2 and CYP3A4 may also contribute to Chlorzoxazone metabolism. Chlorzoxazone has been used as a probe for CYP2E1 activity in microsomes from various sources (e.g., liver, kidney, lung cells) as well as directly in cell cultures. [1] Chlorzoxazone is a centrally acting skeletal muscle relaxant, which acts on the spinal cord by depressing reflexes. Chlorzoxazone is able to activate rat brain SK2 channel currents in cells. The maximal response to Chlorzoxazone is achieved at 1 mM, which is 44% ( 62%) of the response to 1 mM 1-EBIO. [2]

Protocol

Solubility (25°C)

In vitro DMSO 34 mg/mL (200.5 mM)
Ethanol 34 mg/mL (200.5 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 169.57
Formula

C7H4ClNO2

CAS No. 95-25-0
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02405104 Recruiting Osteoarthritis of Hip|Osteoarthritis, Knee Northern Orthopaedic Division, Denmark September 2015 Phase 4
NCT01933542 Completed Chlorzoxazone|Postoperative Pain Rigshospitalet, Denmark|Glostrup University Hospital, Copenhagen August 2013 Phase 4
NCT01187862 Completed Cytochrome|Pharmacokinetics University Hospital, Basel, Switzerland July 2010 Phase 1
NCT00330434 Completed Alcohol Drinking|Depression|Smoking Cessation|Attention Deficit Disorder National Institute on Alcohol Abuse and Alcoholism (NIAAA) December 2005 --

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID