Fenofibrate

Synonyms: NSC-281319

Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.

Fenofibrate Chemical Structure

Fenofibrate Chemical Structure

CAS: 49562-28-9

Selleck's Fenofibrate has been cited by 13 Publications

2 Customer Reviews

Purity & Quality Control

Batch: Purity: 99.99%
99.99

Fenofibrate Related Products

Signaling Pathway

Choose Selective PPAR Inhibitors

Biological Activity

Description Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.
Targets
PPARα [1] CYP2C19 [3]
(Cell-free assay)
CYP2B6 [3]
(Cell-free assay)
CYP2C9 [3]
(Cell-free assay)
0.2 μM 0.7 μM 9.7 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05514119 Recruiting
Liver Transplant
Mayo Clinic
August 17 2022 Phase 2
NCT04650152 Completed
Hypertriglyceridemia|Metabolic Syndrome
Abbott
October 27 2020 --
NCT03869931 Unknown status
Diabetes Mellitus|Diabetic Nephropathies
Singapore General Hospital|National Medical Research Council (NMRC) Singapore
March 8 2019 Phase 3
NCT03557983 Unknown status
Radiodermatitis
Second Affiliated Hospital of Soochow University
June 13 2018 Not Applicable

Chemical Information & Solubility

Molecular Weight 360.83 Formula

C20H21ClO4

CAS No. 49562-28-9 SDF Download Fenofibrate SDF
Smiles CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (199.53 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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