Thiabendazole

Catalog No.S1739

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.

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In DMSO USD 130 In stock
USD 97 In stock
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Thiabendazole Chemical Structure

Thiabendazole Chemical Structure
Molecular Weight: 201.25

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Thiabendazole is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone. [1]A benzimidazole derivative with anthelminthic property. Thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth’s death. [2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Thiabendazole SDF
Molecular Weight (MW) 201.25
Formula

C10H7N3S

CAS No. 148-79-8
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms
Solubility (25°C) * In vitro DMSO 40 mg/mL (198.75 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (4.96 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-​(4-​thiazolyl)​-1H-​benzimidazole

Research Area

Tech Support & FAQs

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