Verapamil HCl
Catalog No.S4202
Molecular Weight(MW): 491.06
Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.
Cited by 1 Publication
Purity & Quality Control
Choose Selective Calcium Channel Inhibitors
Biological Activity
| Description | Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Targets |
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| In vitro |
The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively). |
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| Cell Data |
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| In vivo | Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart. |
Protocol
Solubility (25°C)
| In vitro | DMSO | 98 mg/mL (199.56 mM) |
|---|---|---|
| Water | 50 mg/mL (101.82 mM) | |
| Ethanol | 12 mg/mL (24.43 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 491.06 |
|---|---|
| Formula | C27H38N2O4.HCl |
| CAS No. | 152-11-4 |
| Storage | powder |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03013933 | Not yet recruiting | Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma | City of Hope Medical Center|National Cancer Institute (NCI) | June 2017 | Phase 1 |
| NCT02912663 | Not yet recruiting | Ischemic Stroke | Justin Fraser|University of Kentucky | March 2017 | Phase 1 |
| NCT02823106 | Withdrawn | Ischemic Stroke | Justin Fraser|University of Kentucky | August 2016 | Phase 1 |
| NCT01996436 | Recruiting | Cerebral Vasospasm | The University of Texas Health Science Center, Houston|Yale University|University at Buffalo|Thomas Jefferson University|University of Illinois at Chicago|Mayo Clinic|Wake Forest University Health Sciences|Temple University|Geisinger Clinic|Northwell Health|University of Michigan|Brigham and Womens Hospital|Lenox Hill Hospital | August 2016 | Phase 4 |
| NCT02772354 | Recruiting | Ventricular Arrhythmia | Meshalkin Research Institute of Pathology of Circulation | April 2016 | Phase 2|Phase 3 |
| NCT02653872 | Completed | Healthy Subjects | AstraZeneca | January 2016 | Phase 1 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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