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Abiraterone(CB-7598)
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M.Wt: 349.51
Formula: C24H31NO
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 154229-19-3
Price and Availability of Abiraterone(CB-7598):
Biological Activity of Abiraterone(CB-7598):
Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM.
Abiraterone (CB-7598 is currently undergoing phase II clinical trials as a potential compound for the treatment of prostate cancer. In preclinical studies, abiraterone (CB-7598) has demonstrated the ability to selectively inhibit the target enzyme, resulting in inhibition of testosterone production in both the adrenals and the testes. Clinical studies demonstrated that CYP17 blockade by abiraterone acetate is safe and has significant antitumor activity in CRPC (castration-resistant prostate cancer). [1][2]
References on Abiraterone(CB-7598):
[1] Attard G et al. J Clin Oncol. 2009 Aug 10;27(23):3742-8.
[2] Attard G et al. J Clin Oncol. 2008 Oct 1;26(28):4563-71.
MSDS
Batch S112301: H-NMR HPLC COA
Batch S112302: H-NMR COA
Batch S112303: H-NMR COA
Batch S112304: H-NMR HPLC COA
14a-demethylaseWe give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) See Details
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| Dongfeng Chen, The Rausing Lab |
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| Jun 2011 Selleck Latest Catalog |  |
