Potassium Channel Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1979	Amiodarone HCl	Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.	Cancer Cell, 2025, 43(4):776-796.e14 J Immunother Cancer, 2024, 12(11)e009805 Cell Rep Methods, 2023, 3(4):100440
S2443	Tolbutamide (HLS 831)	Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.	Adv Healthc Mater, 2024, e2303785. iScience, 2024, 27(10):110862 UNIVERSITY OF PÉCS, 2023,
S1716	Glyburide (Glibenclamide)	Glyburide (Glibenclamide), a known blocker of vascular ATP-sensitive K+ channels (KATP), is used in the treatment of type 2 diabetes.	Cell Chem Biol, 2023, S2451-9456(23)00335-5 BMC Vet Res, 2022, 18(1):145 Front Cell Infect Microbiol, 2021, 11:691445
S1658	Dofetilide	Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.	Autophagy, 2025, 1-17. PLoS Pathog, 2020, 16;16(3):e1008341 Toxicol In Vitro, 2020, 104928
S2825	ML133 HCl	ML133 HCl is a selective potassium channel inhibitor for K_ir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on K_ir1.1 and weak activity for K_ir4.1 and K_ir7.1.	Cell Mol Immunol, 2022, 19(8):925-943 Cellular & Molecular Immunology, 2022, 925–943 Nat Commun, 2022, 13(1):3544
S1160	TRAM-34	TRAM-34 (Triarylmethane-34) is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with K_d of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.	Nat Commun, 2024, 15(1):7566 Pflugers Arch, 2023, 475(3):405-416 Cell Mol Immunol, 2022, 19(8):925-943
S1715	Glipizide	Glipizide (CP-28720,K 4024) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.	Journal of Experimental & Clinical Cancer Research, 2025, 294 J Exp Clin Cancer Res, 2025, 44(1):294 Communications Medicine, 2025, 420
S2114	Dronedarone HCl	Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).	Cancers (Basel), 2022, 14(19)4883 Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127 Cell Syst, 2019, 8(2):97-108
S2405	Sophocarpine	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.	J Med Virol, 2019, 91(8):1440-1447 Int J Biol Sci, 2019, 15(11):2497-2508 Front Pharmacol, 2019, 10:1219
S2489	Nateglinide	Nateglinide (Starlix,A-4166,SDZ DJN 608) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.	iScience, 2020, 101446 Cell Syst, 2019, 8(2):97-108 Nature, 2018, 560(7718):372-376
S4495	Quinine	Quinine, an alkaloid derived from the bark of the cinchona tree, is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5.1) channel currents evoked by voltage pulses to +100 mV with IC50 of 169 μM.	Cellular & Molecular Immunology, 2022 Aug, 925-943 Cell Mol Immunol, 2022, 19(8):925-943 J Pharmacol Toxicol Methods, 2017, 90:39-47
S4681	Quinidine hydrochloride monohydrate	Quinidine hydrochloride monohydrate is an anti-arrythmic agent and a potent potassium channel inhibitor with IC50 of 19.9 μM.	Journal of Biomedical Research, 2021, 395-407 Journal of Biomedical Research, 2021, 395-407 J Biomed Res, 2021, 35(5):395-407
S1426	Repaglinide	Repaglinide (AG-EE 623 ZW) is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.	iScience, 2020, 101446 Drug Metab Dispos, 2019, ;47(3):215-226
S2502	Quinine HCl Dihydrate	Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.	Journal of Pharmacological and Toxicological Methods, 2017, 39-47 J Pharmacol Toxicol Methods, 2017, 90:39-47
S2601	Gliclazide	Gliclazide(S1702, SE1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.	IET Syst Biol, 2021, 10.1049/syb2.12034 iScience, 2020, 101446
S5257	Doxapram	Doxapram is a central respiratory stimulant with a brief duration of action. This compound is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively.	Cardiovascular Research, 2022, 1728-1741 Biomed Chromatogr, 2018, 32(10)
E0501	Senicapoc (ICA-17043)	As a Gardos channel(Ca2⁺-activated K⁺ channel; KCa3.1) blocker with an IC50 of 11 nM, Senicapoc (ICA-17043) produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. It blocks Ca2⁺-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.	Nat Commun, 2024, 15(1):7566 Nature Communications, 2024, 7566
S4439	Almitrine mesylate	Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. This compound inhibits the activity of Ca²⁺-dependent K⁺ channel by decreasing its open probability with IC50 of 0.22 μM.	Front Pharmacol, 2025, 16:1539032 Frontiers in Pharmacology, 2025, 1539032
S6627	E-4031 dihydrochloride	E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type.	Sci Rep, 2025, 15(1):29995 Front Pharmacol, 2024, 15:1370676
S1344	Glimepiride	Glimepiride (HOE-490) is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.	Sci Rep, 2017, 7(1):3156
S5371	Ajmaline	Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.	J Immunother Cancer, 2024, 12(11)e009805
S6174	NS8593 Hydrochloride	NS8593 is a potent negative gating inhibitor of small conductance Ca²⁺ -activated K⁺ channels (SK1-3 or Kca2.1-2.3 channels). NS8593 is also a potent inhibitor of the TRPM7 channel with an IC50 of 1.6 µM.	Int J Biol Macromol, 2024, 260(Pt 2):129454
S8016	Vonoprazan Fumarate (TAK-438)	Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), and controls gastric acid secretion. This compound is in Phase 3.
S4489	Tetraethylammonium chloride	Tetraethylammonium (TEA) chloride is a nonspecific potassium channel blocker with antitumor properties.
S6284	Tetraethylammonium bromide	Tetraethylammonium bromide (TEAB, TEA bromide) is used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis. It blocks selective potassium channels.
S0524	A2793	A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
S0741	A2764 dihydrochloride	A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. This compound has the potential for probing the role of TRESK channel in migraine and nociception.
E8113	L-Palmitoylcarnitine chloride	L-Palmitoylcarnitine chloride is a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. It potentially inhibited the KATP channels by interacting with Kir6.2.
E4828	Cloperastine fendizoate	Cloperastine fendizoate (Hustazol) is a sedative used to relieve cough and also has a peripheral action that desensitizes the afferent nerves in the tracheobronchial region. It inhibits the hERG K⁺ currents in a concentration-dependent manner, with an IC50 value of 0.027 μM.
E4806	Quinine dihydrochloride	Quinine dihydrochloride is an antiparasitic used to treat malaria and is particularly important for managing malaria during the first trimester of pregnancy. It inhibits Slo3 (KCa 5.1) channel, which are a significant part of the mammalian KSper (sperm potassium conductance), by binding to hydrophobic side chains located at the intracellular region of the channel pore.
S4037	Doxapram HCl	Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.
S9251	Oxypeucedanin	Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.
S4583	Butamben	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
E0012	1-EBIO	1-EBIO (1-Ethylbenzimidazolinone, 1-Ethyl-2-benzimidazolinone）is an activator of Ca2+-sensitive K+ channels with an EC50 of 490 µM in T84 cells.
E0001	DCPIB	DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). This compound potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. It displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. This chemical is also a novel selective blocker of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM.
S0087	JNJ 303	JNJ 303 is a potent blocker of the voltage dependent I_Ks-channel encoded by KCNQ1/KCNE1 with IC50 of 64 nM. This compound induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
S0090	NS6180	NS-6180 is a highly selective inhibitor of KCa3.1 ion channel with IC50 value of 9 nM, which inhibits T cell activation and inflammation.
S6554	ML365	ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3).
S4186	Domiphen Bromide	Domiphen bromide (NSC-39415) is a quaternary ammonium antiseptic with actions as a cationic surfactant.
S5028	4-Aminopyridine	4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
E4642	CVN293	CVN293 is a potent, selective, and brain permeable small-molecule inhibitor of potassium (K+) ion channel KCNK13 with an IC50s of 49 nM and 28 nM for hKCNK13 and mKCNK13, respectively. It also inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia with an IC50 of 24 nM and has potential applications in Alzheimer’s disease research.
S0188	GSK369796 Dihydrochloride	GSK369796 Dihydrochloride (N-tert-butylisoquine) is an inhibitor of hERG potassium ion channel repolarization with IC50 of 7.5 μM. This compound is an affordable and effective 4-aminoquinoline antimalarial.
S5773	NS1643	NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents.
S4353	Terfenadine	Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. This compound is a potent open-channel blocker of hERG with an IC50 of 204 nM. This chemical, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. It induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
S2073	Mitiglinide Calcium	Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.
S2967	XE991 dihydrochloride	XE 991 (LS190926) dihydrochloride is a blocker of Kv7 (KCNQ) channels that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.
E0144	Vernakalant (RSD1235) Hydrochloride	Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period.
S5749	Chlorpromazine (CPZ)	Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.	EMBO J, 2025, 10.1038/s44318-025-00537-7 Mol Psychiatry, 2025, 10.1038/s41380-025-03374-6 J Thromb Haemost, 2025, 23(9):2926-2943
S2456	Chlorpromazine HCl	Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.	J Colloid Interface Sci, 2024, 664:338-348 Virus Res, 2024, 339:199258 Cell Mol Immunol, 2022, 19(8):925-943
S0398	Astemizole	Astemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. This compound is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. It has antineoplastic and antipruritic effects.	Acta Pharm Sin B, 2023, 13(2):662-677 Acta Pharmaceutica Sinica B, 2023, 662-677 University of Valencia, 2023,
S0476	SCH-23390 hydrochloride	SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390) is a highly potent and selective dopamine D1-like receptor antagonist with Ki of 0.2 nM and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. This compound is a potent and high efficacy agonist at h5-HT2C receptors with Ki of 9.3 nM. It directly inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with IC50 of 268 nM.	Behav Brain Funct, 2025, 21(1):22 Theranostics, 2023, 13(10):3149-3164 JCI Insight, 2023, 8(16)e170434
S9223	Talatisamine	Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
S3242	Loureirin B	Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. This compound downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. It promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the K_ATP current, influx of Ca²⁺ to the intracellular.