Potassium Channel Antagonists

Featured Inhibitors
Inhibitors (53)
Modulators (3)
Chemical (1)
Agonist (1)
Activators (17)
Antagonists (3)

Cat.No.	Product Name	Information	Product Use Citations
S3151	Gliquidone	Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.	Front Aging Neurosci, 2021, 13:754123 Front Cell Dev Biol, 2020, 8:269 Drug Test Anal, 2018, 10(3):609-617
E0378	PAP-1	PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.	Eur J Med Chem, 2023, 259:115561 Eur J Pharmacol, 2022, 933:175242
E1632	VU0463271	VU0463271 is a selective and potent antagonist of neuronal-specific potassium-chloride cotransporter 2 KCC2, with an IC50 of 61 nM. This compound demonstrates over 100-fold selectivity compared to the closely related Na-K-2Cl cotransporter 1 (NKCC1).

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S3151

Gliquidone

Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.

Front Aging Neurosci, 2021, 13:754123

Front Cell Dev Biol, 2020, 8:269

Drug Test Anal, 2018, 10(3):609-617

E0378

PAP-1

PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.

Eur J Med Chem, 2023, 259:115561

Eur J Pharmacol, 2022, 933:175242

E1632

VU0463271

VU0463271 is a selective and potent antagonist of neuronal-specific potassium-chloride cotransporter 2 KCC2, with an IC50 of 61 nM. This compound demonstrates over 100-fold selectivity compared to the closely related Na-K-2Cl cotransporter 1 (NKCC1).