Potassium Channel Modulators

Cat.No.	Product Name	Information	Product Use Citations
E4788	Nigericin	Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.	International Journal of Molecular Sciences, March 20, 2026, 2841 Cancer Research, March 2, 2023, 720-734 Oxidative Medicine and Cellular Longevity, January 5, 2022, 1733834
S0075	ICA-110381	ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 exhibits KCNQ2/Q3 agonist activity with EC50 of 0.38 μM and KCNQ1 antagonist activity with IC50 of 15 μM, respectively.
E0034	CyPPA	CyPPA is a subtype-selective positive modulator of SK channels with EC50s of 5.6 μM and 14 μM for hSK3 and hSK2, repectively. This compound is inactive on both hSK1 and hIK channels.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

E4788

Nigericin

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.

International Journal of Molecular Sciences, March 20, 2026, 2841

Cancer Research, March 2, 2023, 720-734

Oxidative Medicine and Cellular Longevity, January 5, 2022, 1733834

S0075

ICA-110381

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 exhibits KCNQ2/Q3 agonist activity with EC50 of 0.38 μM and KCNQ1 antagonist activity with IC50 of 15 μM, respectively.

E0034

CyPPA

CyPPA is a subtype-selective positive modulator of SK channels with EC50s of 5.6 μM and 14 μM for hSK3 and hSK2, repectively. This compound is inactive on both hSK1 and hIK channels.