Estrogen/progestogen Receptor Agonists

Cat.No.	Product Name	Information	Product Use Citations
S1705	Progesterone	Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. This compound is a potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; an agonist of the membrane progesterone receptors(mPRs); an antagonist of the σ1 receptor.	Bone Res, 2025, 13(1):37 Cell Proliferation, 2025, e70025 Nat Commun, 2024, 15(1):8708
S1859	Diethylstilbestrol	Diethylstilbestrol (Stilbestrol) is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.This compound can be used to induce animal models of Pituitary Adenoma.	Communications Medicine, 2025, 1-15 Biomaterials Research, 2024, 0010 iScience, 2024, 27(10):110862
S4154	Cholesterol	Cholesterol(Cholesterin) is the principal sterol of all higher animals required to build and maintain membranes.	Advanced Science, 2025, e2413103 Nat Commun, 2024, 15(1):6740 Nature Communications, 2024, 6740
S4673	Etonogestrel	Etonogestrel (Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel) is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.	Pharmaceutics, 2024, 16(8)1030 Pharmaceutics, 2024, 1030 Biomaterials, 2023, 301:122260
S7828	Licochalcone A	Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.	European Journal of Pharmacology, October 15, 2023, 176031 BioMed Research International, March 10, 2022, 5687832 Oncology Reports, December 14, 2017, 1181-1190
S3149	Estradiol valerate	Estradiol(E2V) is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.	Frontiers in Immunology, October 20, 2022, 1026214 Cell Discovery, August 12, 2025, 68 Cell Discovery, 2025, 68
S4046	Estradiol Cypionate	Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.	Nat Commun, 2024, 15(1):4549 Nature Communications, 2024, 4549 Cell Death Dis, 2024, 15(8):590
S1727	Levonorgestrel	Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.	Cancers (Basel), 2025, 17(4)598 Pharmaceuticals -Basel, 2022, 15-101226 J Control Release, 2021, S0168-3659(21)00550-2
S4110	Estradiol Benzoate	Estradiol benzoate(β-Estradiol 3-benzoate) is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.	J Pain Res, 2025, 18:3573-3592 Neural Plast, 2023, 2023:5225952 Front Pharmacol, 2022, 13:841941
S2473	Hexestrol	Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.	Cell Syst, 2024, 15(12):1107-1122.e7 iScience, 2024, 27(10):110862 Cancers (Basel), 2019 Oct 19, 1596
S1625	Ethinyl Estradiol	Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.	Journal of Cancer, 2021, 4623-4631 Hum Mol Genet, 2020, ddaa244 Regul Toxicol Pharmacol, 2020, S0273-2300(20)30246-4
S3929	Liquiritigenin	Liquiritigenin (4',7-Dihydroxyflavanone), the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.	Chin Med, 2024, 19(1):12 Biomedicine & Pharmacotherapy, 2021 Nov, 112167 Biomedicine & Pharmacotherapy, 2021, 112167
S5469	Bavachin	Bavachin (Corylifolin) is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. It acts as a weak phytoestrogen by binding and activating the ER.	Animal Cells and Systems, 2025, 28-39 iScience, 2024, 109275 Biomedical Reports, 2016, 87-92
S1858	Dienestrol	Dienestrol(Restrol) is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist.	iScience, 2024, 27(10):110862 Biomater Res, 2024, 28:0010
S1904	Avobenzone	Avobenzone (Butyl methoxydibenzoylmethane, BF2AVB) is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative.	ProQuest, 2023, 30000028 Reprod Toxicol, 2018, 81:50-57
S1598	Erteberel (LY500307)	Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, demonstrating 32-fold selectivity against estrogen receptor α. It is currently in Phase 2.	University of North Texas, 2014, Health Science Center at Fort Worth
S2450	Equol	Equol, a metabolite of soybeans, is an important isoflavone in humans, specifically binds to 5α-DHT, and has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.	ACS Chem Biol, 2015, 10.1021/cb5009487
S5872	Estradiol dipropionate	Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a semisynthetic, steroidal estrogen which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the treatment of gynecological disorders.	Pharmaceuticals (Basel), 2022, 16(1)25
E0940	Propyl pyrazole triol (PPT)	Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist.	Ecotoxicol Environ Saf, 2025, 290:117743
S3635	Medroxyprogesterone	Medroxyprogesterone (MP) is a synthetic pregnane steroid and a derivative of progesterone. It is a potent progesterone receptor agonist.	Theranostics, 2024, 593-607
S4674	Hydroxyprogesterone caproate	Hydroxyprogesterone Caproate (17α-Hydroxyprogesterone hexanoate, 17α-Hydroxyprogesterone caproate) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.	Nat Commun, 2024, 15(1):8708 Nature Communications, 2024, 8708
S9629	Elacestrant (RAD1901) Dihydrochloride	Elacestrant (RAD1901) Dihydrochloride is an orally available selective estrogen receptor degrader (SERD) with IC50 of 48 nM and 870 nM for ERα and ERβ, respectively.	Front Oncol, 2022, 12:857590
S3449	GSK5182	GSK5182, 4-hydroxytamoxifen analog, is a specific inverse agonist of estrogen-related receptor γ (ERRγ) that inhibits pro-inflammatory cytokine-induced catabolic factors.	Nat Genet, 2023, 55(2):187-197
S2125	Mestranol	Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.
S3167	Altrenogest	Altrenogest (A35957, RU2267,R2267) is a progestogen structurally related to veterinary steroid trenbolone.
S6601	(±)-Equol	(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.
S5676	Zearalenone	Zearalenone (F2 toxin, RAL) is a non-steroidal estrogenic mycotoxin that acts by binding the estrogen receptor (ER).
E1903	SLU-PP-332	SLU-PP-332 is an agonist of pan-Estrogen Receptor/ERR with EC50 values of 98nM, 230nM, and 430 nM for ERRα, ERRβ, and ERRγ, respectively with the highest potency for ERRα. SLUPP-332 amplifies mitochondrial function and cellular respiration in skeletal muscle cell lines and also offers opportunities for researching metabolic ailments and enhancing muscle functionality.
S5288	Estropipate	Estropipate (Piperazine estrone sulfate, Estrone sulfate piperazine salt, Pipestrone) is a natural estrogenic substance composed of estrone sulfate and piperazine and is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms.
S5320	Octinoxate	Octinoxate (Octyl methoxycinnamate, ethylhexyl methoxycinnamate) is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
S4638	Desogestrel	Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
S0358	GSK4716	GSK4716 is a selective agonist of Estrogen-Related Orphan Nuclear Receptors ERR and ERRγ with an IC50 of 2 µM in the ERRγ FRET assay.
S3657	Promestriene	Promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application.
S4883	Lynestrenol	Lynestrenol (Ethinylestrenol) is a synthetic progestational hormone, an agonist of the progesterone receptor and has weak androgenic and estrogenic activity.
E0707	Nomegestrol Acetate	Nomegestrol Acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.
S0143	WAY-200070	WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
S3671	Quinestrol	Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.
S4097	Dydrogesterone	Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
S0407	XCT790	XCT-790 (Compound 12) is a potent and selective inverse agonist for estrogen-related receptor α (ERRα) with IC50 of 0.37 μM. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ. XCT-790 (Compound 12) significantly inhibits in vivo tumor growth and angiogenesis, and induces apoptosis.
S4507	17-Hydroxyprogesterone	17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
S5464	Psoralidin	Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as anticancer, antioxidant, antibacterial, antidepressant, anti-inflammatory activities, and regulation of insulin signaling. It is an agonist for both estrogen receptor (ER)α and ERβ with binding affinities (IC50s) of 1.03 and 24.6 μM, respectively.
S3160	Ethynodiol diacetate	Ethynodiol diacetate (8080 CB,Ethynodiol acetate) is one of the first synthetic progestogens used in contraceptive pills.
S2611	Ethisterone	Ethisterone(17α-Ethynyltestosterone) is a progestogen hormone being considered to treat prostate cancer.
S6810	Diarylpropionitrile (DPN)	Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β (ERβ) agonist with EC50 of 0.85 nM, 72-fold more selective for ERβ than ERα.
S1709	17β-Estradiol	Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.	Cancer Cell, 2025, 43(5):891-904.e10 Nat Commun, 2025, 16(1):758 Cell Rep Med, 2025, 6(7):102192
S2567	Medroxyprogesterone Acetate (MPA)	MPA (Medroxyprogesterone acetate) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.	Cancer Sci, 2025, 10.1111/cas.70081 Cell Prolif, 2024, e13780. J Transl Med, 2024, 22(1):478
S3617	(20S)-Protopanaxatriol	(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).