Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Quinestrol

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Quinestrol Estrogen/progestogen Receptor agonist

Cat.No.S3671

Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.
Quinestrol Estrogen/progestogen Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 364.52

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Quality Control

Batch: S367101 DMSO]72 mg/mL]false]Ethanol]72 mg/mL]false]Water]Insoluble]false Purity: 99.89%
99.89

Solubility

In vitro
Batch:

DMSO : 72 mg/mL (197.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 364.52 Formula

C25H32O2

 Storage (From the date of receipt)
CAS No. 152-43-2 Download SDF Storage of Stock Solutions

Synonyms Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566 Smiles CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5

Mechanism of Action

In vitro
Quinestrol (17-alpha ethinylestradiol-3-cyclopentyl ether), a derivative of ethinylestradiol, is a long-acting synthetic estrogen. Its estrogenic activity is about 8 to 10 times that of its matrix, and it has strong antifertility effects.
In vivo
Animal experiments show that after oral administration, quinestrol is absorbed by the gastrointestinal tract and stored in the adipose tissue; then it is gradually released into the bloodstream at low levels to maintain a long-lasting effective concentration. Male gerbils exposed to this compound show a significant decrease in epididymides, seminal vesicles, semen quality, and reproductive rates. This chemical treatment causes an imbalance in the oxidation and antioxidant system in blood and testicular tissue. It induces ROS and simultaneously reduces antioxidant enzyme activity, leaving germ cells in their oxidation state, which results in spermatogenic cell damage. .
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