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Quinestrol

Name: Quinestrol
Brand: Selleck Chemicals
SKU: S3671
Rating: 5 (1 reviews)

Synonyms: Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566

Catalog No.S3671 Purity: 99.89%

Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.

Quinestrol Chemical Structure

CAS: 152-43-2

Purity & Quality Control

Batch: S367101 DMSO] 72 mg/mL] false] Ethanol] 72 mg/mL] false] Water] Insoluble] false Purity: 99.89%

99.89

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Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description	Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.

In vitro
In vitro	Quinestrol (17-alpha ethinylestradiol-3-cyclopentyl ether), a derivative of ethinylestradiol, is a long-acting synthetic estrogen. Its estrogenic activity is about 8 to 10 times that of its matrix, and it has strong antifertility effects^[1].

In Vivo
In vivo	Animal experiments show that after oral administration, quinestrol is absorbed by the gastrointestinal tract and stored in the adipose tissue; then it is gradually released into the bloodstream at low levels to maintain a long-lasting effective concentration. Male gerbils exposed to quinestrol show a significant decrease in epididymides, seminal vesicles, semen quality, and reproductive rates. Quinestrol treatment causes an imbalance in the oxidation and antioxidant system in blood and testicular tissue. Quinestrol induces ROS and simultaneously reduces antioxidant enzyme activity, leaving germ cells in their oxidation state, which results in spermatogenic cell damage. ^[1].
Animal Research	Animal Models	adult male gerbils
	Dosages	3.5 and 35 mg/kg
	Administration	oral gavage

References

[1] Shen W, et al. Exp Anim. 2011, 60(5):445-53.

Chemical Information & Solubility

Molecular Weight	364.52	Formula	C₂₅H₃₂O₂
CAS No.	152-43-2	SDF	Download Quinestrol SDF
Smiles	CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 72 mg/mL ( (197.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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