Desogestrel

Catalog No.S4638 Synonyms: Cerazette, Desogen, Desogestrelum, Org-2969

For research use only.

Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.

Desogestrel Chemical Structure

CAS No. 54024-22-5

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

Other Estrogen/progestogen Receptor Products

Biological Activity

Description Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
In vivo Desogestrel is extensively metabolized after oral administration to rats and dogs; In rats, desogestrel is metabolized mainly at the C3, C5, C11, and C15 positions. An hydroxy group is introduced at the 15α-position of desogestrel, followed by conjugation with glucuronic acid. In dogs, desogestrel is mainly metabolized at the C3- and C17-positions[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Female Wistar rats, Female beagle dogs
  • Dosages: 56 μg/kg, 106 mg/kg (Rats); 67 μg/kg, 9.6 mg/kg(Dogs)
  • Administration: oral administration

Solubility (25°C)

In vitro

DMSO 62 mg/mL
(199.69 mM)
Ethanol 62 mg/mL
(199.69 mM)
Water Insoluble

Chemical Information

Molecular Weight 310.47
Formula

C22H30O

CAS No. 54024-22-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CCCCC34

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Desogestrel | Desogestrel ic50 | Desogestrel price | Desogestrel cost | Desogestrel solubility dmso | Desogestrel purchase | Desogestrel manufacturer | Desogestrel research buy | Desogestrel order | Desogestrel mouse | Desogestrel chemical structure | Desogestrel mw | Desogestrel molecular weight | Desogestrel datasheet | Desogestrel supplier | Desogestrel in vitro | Desogestrel cell line | Desogestrel concentration | Desogestrel nmr