Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist - Progesterone Receptor agonist Desogestrel

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Desogestrel Estrogen/progestogen Receptor agonist

Cat.No.S4638

Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Desogestrel Estrogen/progestogen Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 310.47

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Quality Control

Batch: S463801 DMSO]62 mg/mL]false]Ethanol]62 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 310.47 Formula

C22H30O

 Storage (From the date of receipt)
CAS No. 54024-22-5 Download SDF Storage of Stock Solutions

Synonyms Cerazette, Desogen, Desogestrelum, Org-2969 Smiles CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CCCCC34

Solubility

In vitro
Batch:

DMSO : 62 mg/mL (199.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

In vivo
Desogestrel is extensively metabolized after oral administration to rats and dogs; In rats, this compound is metabolized mainly at the C3, C5, C11, and C15 positions. An hydroxy group is introduced at the 15α-position of this chemical, followed by conjugation with glucuronic acid. In dogs, it is mainly metabolized at the C3- and C17-positions[1].
References

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