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Estradiol Cypionate

Name: Estradiol Cypionate
Brand: Selleck Chemicals
SKU: S4046
Rating: 5 (2 reviews)

Catalog No.S4046 Purity: 99.88%

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

Estradiol Cypionate Chemical Structure

CAS: 313-06-4

Selleck's Estradiol Cypionate has been cited by 2 publications

Purity & Quality Control

Batch: S404601 DMSO] 79 mg/mL] false] Ethanol] 55 mg/mL] false] Water] Insoluble] false Purity: 99.88%

99.88

Estradiol Cypionate Related Products

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Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

Targets

ER ^[1]

In vitro
In vitro	Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively.^[1] Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix. ^[2]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03443089	Completed	Contraception	Galeno Desenvolvimento de Pesquisas Clínicas\|Biolab Sanus Farmaceutica	March 31 2017	Phase 1

References

Chemical Information & Solubility

Molecular Weight	396.56	Formula	C₂₆H₃₆O₃
CAS No.	313-06-4	SDF	Download Estradiol Cypionate SDF
Smiles	CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=C3C=CC(=C5)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 79 mg/mL ( (199.21 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 55 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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