Estradiol Cypionate

For research use only.

Catalog No.S4046

1 publication

Estradiol Cypionate Chemical Structure

Molecular Weight(MW): 396.56

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

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Selleck's Estradiol Cypionate has been cited by 1 publication

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Biological Activity

Description Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
Targets
ER [1]
In vitro

Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively.[1] Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix. [2]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (199.21 mM)
Ethanol 55 mg/mL (138.69 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 396.56
Formula

C26H36O3

CAS No. 313-06-4
Storage powder
in solvent
Synonyms N/A
Smiles CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2OC(=O)CCC5CCCC5

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Estrogen/progestogen Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID