Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Estradiol Cypionate

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Estradiol Cypionate Estrogen/progestogen Receptor agonist

Cat.No.S4046

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
Estradiol Cypionate Estrogen/progestogen Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 396.56

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Quality Control

Batch: S404601 DMSO]79 mg/mL]false]Ethanol]55 mg/mL]false]Water]Insoluble]false Purity: 99.88%
99.88

Solubility

In vitro
Batch:

DMSO : 79 mg/mL (199.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 55 mg/mL

Water : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 396.56 Formula

C26H36O3

 Storage (From the date of receipt)
CAS No. 313-06-4 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=C3C=CC(=C5)O

Mechanism of Action

Targets/IC50/Ki
ER
In vitro
Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively. Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03443089 Completed
Contraception
Galeno Desenvolvimento de Pesquisas Clínicas|Biolab Sanus Farmaceutica
 March 31 2017 Phase 1

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