Estradiol Cypionate

Catalog No.S4046

For research use only.

Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.

Estradiol Cypionate Chemical Structure

CAS No. 313-06-4

Selleck's Estradiol Cypionate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.
Targets
ER [1]
In vitro

Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively.[1] Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 79 mg/mL
(199.21 mM)
Ethanol 55 mg/mL
(138.69 mM)
Water Insoluble

Chemical Information

Molecular Weight 396.56
Formula

C26H36O3

CAS No. 313-06-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=C3C=CC(=C5)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03443089 Completed Drug: Test formulation|Drug: Reference formulation Contraception Galeno Desenvolvimento de Pesquisas Clínicas|Biolab Sanus Farmaceutica March 31 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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