Hydroxyprogesterone caproate

Catalog No.S4674 Synonyms: 17α-Hydroxyprogesterone hexanoate, 17α-Hydroxyprogesterone caproate

For research use only.

Hydroxyprogesterone Caproate (17α-Hydroxyprogesterone hexanoate, 17α-Hydroxyprogesterone caproate) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.

Hydroxyprogesterone caproate Chemical Structure

CAS No. 630-56-8

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Biological Activity

Description Hydroxyprogesterone Caproate (17α-Hydroxyprogesterone hexanoate, 17α-Hydroxyprogesterone caproate) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.
In vivo Hydroxyprogesterone caproate is administered to pregnant rats in order to assess the effect of intraperitoneal exposure to supranormal levels of hydroxyprogesterone caproate on the male reproductive potential in the first generation. The cauda epididymal sperm count and motility decrease significantly in rats exposed to hydroxyprogesterone caproate during embryonic development, when compared with control rats. The levels of serum testosterone decrease with an increase in follicle stimulating hormone and luteinizing hormone in adult rats exposed to hydroxyprogesterone caproate during the embryonic stage[2].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Sprague Dawley rats
  • Dosages: 0, 5, 25, and 150 mg/kg
  • Administration: i.m.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 428.60
Formula

C27H40O4

CAS No. 630-56-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(=O)C

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01899846 Completed Drug: Hydroxyprogesterone caproate 250 mg/ml Pregnancy Lumara Health Inc. July 2013 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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