Molecular Weight(MW): 434.54
Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.
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|Description||Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.|
|Features||Orally bioavailable CDK4/6-selective inhibitor that has been tested in Phase III clinical trials for treatment of advanced breast cancer.|
LEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and cellular senescence. 
|In vivo||LEE011 (200 mg/kg daily, p.o.) significantly causes tumor growth delay in mice harboring the BE2C or 1643 xenografts with no weight loss or other signs of toxicity. |
|In vitro||DMSO||7 mg/mL (16.1 mM)|
* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02657928||Recruiting||Estrogen Receptor Positive|Postmenopausal|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Uterine Corpus Carcinoma||Mayo Clinic|National Cancer Institute (NCI)||July 2016||Phase 2|
|NCT02780128||Recruiting||Neuroblastoma|Cancer||Yael P Mosse|Novartis Pharmaceuticals|Foundation Medicine|Childrens Hospital of Philadelphia||July 2016||Phase 1|
|NCT02734615||Recruiting||Advanced or Metastatic ER+ Breast Cancer||Novartis Pharmaceuticals|Novartis||June 2016||Phase 1|
|NCT02732119||Recruiting||Breast Cancer||Novartis Pharmaceuticals|Novartis||June 2016||Phase 1|Phase 2|
|NCT02703571||Recruiting||Solid Tumors|Pancreatic Cancer|Colorectal Cancer||Novartis Pharmaceuticals|Novartis||June 2016||Phase 1|Phase 2|
|NCT02813135||Recruiting||Children, Adolescents and Young Adults With Refractory or Recurrent Malignancies||Gustave Roussy, Cancer Campus, Grand Paris|National Cancer Institute, France||June 2016||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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