Home Cell Cycle CDK CDK12 Selective Inhibitors

CDK12 Selective Inhibitors

  • CDK1
  • CDK2
  • CDK3
  • CDK4
  • CDK5
  • CDK6
  • CDK7
  • CDK9
  • CLK
  • Cdc
  • CDK8
  • CDK12
  • CDK13
  • CDK19
  • CDK11
  • CDK/cyclin complexes
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S9859 BSJ-4-116 BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects. Selective
S8894 SR-4835 SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors. Pan CDK12, IC50: 99 nM; CDK12, Kd: 98 nM
S6595 THZ531 THZ531 is a selective covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively. Pan CDK12, IC50: 158 nM