CLK Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7320 TG003

TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC.

Selective CLK4, IC50: 15 nM; CLK2, IC50: 200 nM; CLK1, IC50: 20 nM
S7509 ML167

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.

Selective Dyrk1B , IC50: 4420 nM; CLK2, IC50: 1648 nM; CLK1, IC50: 1522 nM; CLK4, IC50: 136 nM