CLK Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC.
|Selective||CLK4, IC50: 15 nM; CLK2, IC50: 200 nM; CLK1, IC50: 20 nM|
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
|Selective||Dyrk1B , IC50: 4420 nM; CLK2, IC50: 1648 nM; CLK1, IC50: 1522 nM; CLK4, IC50: 136 nM|