Cdc Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7547 XL413 (BMS-863233)

XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.

Selective Cdc7, IC50: 3.4 nM
S2742 PHA-767491

PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.

Pan Cdc7, IC50: 10 nM