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STAT Inhibitors (8)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1155 S3I-201 S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5.
  • Cancer Discov, 2013, 3(2):158-67
  • Sci Signal, 2014, 7(322):ra38
  • Mol Cancer, 2011, 10:66
S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor.
  • Cell Death Dis, 2014, 5:e1512
  • Mol Cell Biol, 2014, 34(24):4368-78
  • J Biol Chem, 2014, 289(14):9952-60
S7024 Stattic Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.
  • J Biol Chem, 2013, 288(8):5553-61
  • FEBS Lett, 2015, 589(1):52-8
  • Human Pathology, 2015, 46(2):284-94
S3030 Niclosamide Niclosamide can inhibit DNA replication and inhibit STAT with IC50 of 0.7 μM.
S4182 Nifuroxazide Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells
S7337 SH-4-54 SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
S7501 HO-3867 HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
S2285 Cryptotanshinone Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5.

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