Niclosamide

Catalog No.S3030 Synonyms: Niclocide

Niclosamide Chemical Structure

Molecular Weight(MW): 327.12

Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).

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  • Bacterial infection in IPEC-J2 cells. The invasion and attachment of EHECO157:H7 was increased in the IPEC-J2 cells in the presence of 1 μM niclosamide. Data are expressed as the mean ± SEM (n= 6). Differences between groups were determined by paired samples t-test. *P<0.05 compared with the control.

    Int Immunopharmacol, 2016, 36:199-204.. Niclosamide purchased from Selleck.

    Inhibition of STAT3 phosphorylation by niclosamide in colon cancer cells HCT116 and SW620. Notes: (A) SW620 cells were treated with niclosamide (5 µM) for different lengths of time (0, 2, 4, 6, 8, and 12 h). Total protein was extracted, and the expression levels of P-STAT3, STAT3, and GAPDH proteins were detected by Western blot analysis. (B) HCT116 cells were treated with niclosamide (5 µM) for different lengths of time (0, 2, 4, 6, 8, and 12 h). Total protein was extracted, and the expression levels of P-STAT3, STAT3, and GAPDH proteins were detected by Western blot analysis. (C) SW620 cells were treated with niclosamide at different concentrations (0.5, 1, 2.5, 5, and 10 µM) or vehicle control (DMSO) for 12 h. (D) HCT116 cells were treated with niclosamide at different concentrations (0.5, 1, 2.5, 5, and 10 µM) or vehicle control (DMSO) for 12 h. Total protein was then extracted and detected by Western blot analysis. The data were obtained from 3 independent experiments. *P<0.05.

    Onco Targets Ther, 2017, 10:1767-1776. Niclosamide purchased from Selleck.

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Biological Activity

Description Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
Targets
STAT3 [1]
(Cell-free assay)
0.7 μM
In vitro

Niclosamide (< 5 μM) dose dependently inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25 μM in HeLa cells. Niclosamide(< 2 μM) dose dependently inhibits the phosphorylation of STAT3 in Du145 cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide(< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide(< 10 μM) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells. [1] Niclosamide is able to inhibit SARS-CoV replication at a micromolar concentration in Vero E6 cells infected with SARS-CoV. [2] Niclosamide(< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells. [3] Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide(125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide(< 500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB–DNA complex in HL-60 cells. Niclosamide(< 10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide(500 nM) decreases TNF-induced NF-κB–dependent gene products involved in cell survival in HL-60 cells. Niclosamide dose dependently inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Vero E6 cells M4G2U2Z2dmO2aX;uJIF{e2G7 MYTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDTRXJUKGOxcn;uZZZqenW|IHnuJHZmem9iRU[gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCkeTDFUGlUSSxiRVO1NF0xNjFizszN M33HcVE4PjZ|NUO5
human blood cancer cells MYPDfZRwfG:6aXRCpIF{e2G7 MnzJO|IhcA>? MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDicI9w\CClYX7j[ZIh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGxiVHn0[ZIhT2yxIFHzd4F6NCCLQ{WwQVAvOTNizszN MkPUNlYzPzJyM{K=
human pancreatic cancer cells M13TR2N6fG:2b4jpZ:Kh[XO|YYm= NWO0W5M3PzJiaB?= NHnSOWxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBx[W6lcnXheIlkKGOjbnPldkBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdCCWaYTldkBIdG9iQYPzZZktKEmFNUC9NE4yOyEQvF2= NGrlW3czPjJ5MkCzNi=>
human ovarian cancer cells NEG5eWhEgXSxdH;4bYPDqGG|c3H5 MmXvO|IhcA>? MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDveoFzcWGwIHPhcoNmeiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubDDUbZRmeiCJbH:gRZN{[XluIFnDOVA:OC5zMzFOwG0> NVniR41KOjZ{N{KwN|I>
human lung cancer cells MmrQR5l1d3SxeHnjxsBie3OjeR?= M3yyWFczKGh? MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDseY5oKGOjbnPldkBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdCCWaYTldkBIdG9iQYPzZZktKEmFNUC9NE4yOyEQvF2= NYPMTWpsOjZ{N{KwN|I>
human colon cancer cells M1;GV2N6fG:2b4jpZ:Kh[XO|YYm= M4fzU|czKGh? MmXpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuIGTpeIVzKEeubzDBd5NigSxiSVO1NF0xNjF|IN88US=> MnW2NlYzPzJyM{K=
human prostate cancer cells MlLuR5l1d3SxeHnjxsBie3OjeR?= NGfGSWI4OiCq NVvoPG9pS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKxc4TheIUh[2GwY3XyJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtKFSrdHXyJGdtdyCDc4PhfUwhUUN3ME2wMlE{KM7:TR?= M2fBZ|I3Ojd{MEOy
human breast cancer cells M1m2cWN6fG:2b4jpZ:Kh[XO|YYm= NYD2VJg3PzJiaB?= MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDidoVie3RiY3HuZ4VzKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuIGTpeIVzKEeubzDBd5NigSxiSVO1NF0xNjF|IN88US=> NIqzOYozPjJ5MkCzNi=>
human HeLa cells NH3DcoxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFe4bZUzPCCq NWXo[XoxUW6qaXLpeIlwdiCxZjDTWGFVOyCrbjDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6yOUDPxE1? NGL5WY8zPDlyMEKzNS=>
HEK293 cells MXvGeY5kfGmxbjDhd5NigQ>? M3vGU|ghcA>? NI\ifGRKdmirYnn0bY9vKG:oIGfueE9j\XSjLXPheIVvcW5iaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhX262M1Gtd5RqdXWuYYTl[EBVV1CIbHHzbEBi[3Srdnn0fUBi\nSncjC4JIhzeyxiSVO1NF0xNjN2IN88US=> MojXNlYzPzJyM{K=
human PC3 cells MUfQdo9tcW[ncnH0bY9vKGG|c3H5 NETtXZYyOjBiaB?= NXTFbZIySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiMUKwJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD60JO69VQ>? MW[xOlY5ODF3OR?=
HEK293 cells MV;GeY5kfGmxbjDhd5NigQ>? MXu4JIg> MnTnTY5pcWKrdHnvckBw\iCZboSzRU9j\XSjLXPhd4VqdiC|aXfuZYxqdmdiaX6gTGVMOjl|IHPlcIx{KGGodHXyJFghcHK|IHL5JHRQWG[uYYPoJJJmeG:{dHXyJIF{e2G7LDDJR|UxRTBwNDFOwG0> NELSPVkzOzR3M{C3Ny=>
human A549 cells NVThdmx6WHKxbHnm[ZJifGmxbjDhd5NigQ>? M1HEbFEzOCCq M1PMeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiBzMkCgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkSg{txO NH34UlMyPjZ6MEG1PS=>
human U87MG cells NV3WRplsWHKxbHnm[ZJifGmxbjDhd5NigQ>? MlziNVIxKGh? NFW1Z5lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW4O21IKGOnbHzzJIFnfGW{IEGyNEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOEDPxE1? MVGxOlY5ODF3OR?=
human HCT116 cells M4DwOWN6fG:2b4jpZ:Kh[XO|YYm= Mo\ZO|IhcA>? MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0xNjR3IN88US=> MlPmNlYzPzJyM{K=
human DU145 cells M4DZXXBzd2yrZnXyZZRqd25iYYPzZZk> MmPJO|IhcA>? NYjre|VUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuO{DPxE1? M3n4TVI1QTByMkOx
human LoVo cells MnT1VJJwdGmoZYLheIlwdiCjc4PhfS=> NV3xdHZbOTJyIHi= NV;pRppqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMc3ZwKGOnbHzzJIFnfGW{IEGyNEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuO{DPxE1? MXyxOlY5ODF3OR?=
human MCF7 cells M{DQTGN6fG:2b4jpZ:Kh[XO|YYm= Mkm2R5l1d3SxeHnjbZR6KGGpYXnud5QhTVJvcH;zbZRqfmViaIXtZY4hVUOINzDj[YxteyCkeTDNWHMh[XO|YYmsJGlEPTBiPUGuNFYh|ryP NGDZN|YzOzRzNkG5NS=>
human MIAPaCa2 cells M4TNR3Bzd2yrZnXyZZRqd25iYYPzZZk> NEj4SXEyOjBiaB?= NIPBNG1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3JRXBiS2F{IHPlcIx{KGGodHXyJFEzOCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEvOSEQvF2= MYKxOlY5ODF3OR?=
MDA-MB-231 cells MXLDfZRwfG:6aXRCpIF{e2G7 MmK3O|IhcA>? MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFVkBv\WejdHn2[UBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGlEPTB;MD63PUDPxE1? NY\abWh7OjN2NUm2NVM>
human HeLa cells NX7SeFltWHKxbHnm[ZJifGmxbjDhd5NigQ>? MUK3NkBp MnTSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OS52IN88US=> NVW3dVhIOjR7MECyN|E>
human AsPC1 cells NWrWZWZiS3m2b4TvfIlkyqCjc4PhfS=> Mn7kO|IhcA>? MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBd3BEOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUGuOFch|ryP MUWyN|Q2QTZzMx?=
human PANC1 cells MlHqR5l1d3SxeHnjxsBie3OjeR?= MWC3NkBp NV[0SnlsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0yNjd|IN88US=> NYfLV2F1OjN2NUm2NVM>
human A549 cells  NXjUWW5LWHKxbHnm[ZJifGmxbjDhd5NigQ>? MUi3NkBp MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0{KM7:TR?= NWrtdWRDOjR7MECyN|E>
human HT-29 cells NYrhUo9qWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1XUZlczKGh? NFLwUmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Nz6yJO69VQ>? NVTO[YdFOjR7MECyN|E>
human A431 cells NVj5[XZKWHKxbHnm[ZJifGmxbjDhd5NigQ>? MUe3NkBp M2DHXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRThwODFOwG0> NV;PU3U4OjR7MECyN|E>
human Ava5 cells MYHDfZRwfG:6aXRCpIF{e2G7 MoDoN{Bl[Xm| MnvER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRZZiPSClZXzsd{Bi\nSncjCzJIRigXNiYomgcoV2fHKjbDDy[YQh\HmnIHHzd4F6NCCFQ{WwQVExKM7:TR?= M2\U[lIzODV7OUiz
human PC3 cells NVrBTGZ1WHKxbHnm[ZJifGmxbjDhd5NigQ>? NEHjVHU4OiCq M{D3VWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTFwNzFOwG0> NUCx[WpyOjR7MECyN|E>
mouse RAW264.7 cells NVnVN494TnWwY4Tpc44h[XO|YYm= NHzwfZIyOCEQvF2= NWfwWldOS3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDhcpRpemG6IITvfIlvKGyndHjhcEBn[WO2b4KvdJJwfGWldHn2[UBidnSrZ3XuMYlv\HWlZXSgZ4VtdCCmZXH0bEBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEAyOCC3TTDifUBOXFRicnXkeYN1cW:wIHHzd4F6 Mn;rNVk2PDB5NkS=
CHO cells MkLISpVv[3Srb36gZZN{[Xl? M{f0U2N6fG:ycn;0[YN1cX[nIHHjeIl3cXS7IHHnZYlve3RiYX70bJJigCCodYPpc44hfG:6aX6gSnA2QS2rbnT1Z4VlKGOnbHyg[IVifGhiaX6gR2hQKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIJ6KE2WVDDy[YR2[3Srb36gZZN{[Xl? NEHVXY0yQTV2MEe2OC=>
human HeLa cells M4XNV2Z2dmO2aX;uJIF{e2G7 MUG1JO69VQ>? MmG3NlQhcA>? NYKyPVJFUW6qaXLpeIlwdiCxZjDTWGFVOyCrbjDoeY1idiCKZVzhJINmdGy|IHH0JFUhfU1iYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= M3my[|I1QTByMkOx
human U2OS cells MWXGeY5kfGmxbjDhd5NigQ>? MmjRNVIvPSEQvF2= M3POS|YhcA>? MV3JcoR2[3Srb36gc4YhcW62ZYLuZYxqgmG2aX;uJI9nKE[{aYr6cIVlOS2JRmCgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hcHWvYX6gWVJQWyClZXzsd{BifCBzMj61JJVOKGGodHXyJFYhcHK|IHL5JINwdm[xY3HsJI1q[3Kxc3PvdJk> NX7qOJFnOjN2NUOwO|M>

... Click to View More Cell Line Experimental Data

In vivo Niclosamide(40 mg/kg/d, i.p.) inhibits growth of xenografted AML cells in nude mice bearing HL-60 xenograft tumors. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Protein Kinase profiling assay:

Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28.
Cell Research:

[1]

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  • Cell lines: Hela, A549, Du145, HT-29, A431, PC3 cells
  • Concentrations: 16 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are plated in 96-well culture plates with cell density of 3-4 × 103 cells/well and treat with Niclosamide by adding 100 μL medium containing Niclosamide of various concentrations on the second day. After 72-hour's treatment, MTT is added to each well and incubated for additional 4-5 hours, and the absorbance is measured on a microplate reader at 570nm. Cell growth inhibition is evaluated as the ratio of the absorbance of the sample to that of the control. The results are representative of at least 3 independent experiments.


    (Only for Reference)
Animal Research:

[4]

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  • Animal Models: nude mice bearing HL-60 xenograft tumors.
  • Formulation: DMSO
  • Dosages: 40 mg/kg
  • Administration: Intraperitoneal injection
    (Only for Reference)

Solubility (25°C)

In vitro DMF 12 mg/mL warmed (36.68 mM)
DMSO Insoluble
Water Insoluble
In vivo Add solvents individually and in order:
1% DMSO+30% polyethylene glycol+1% Tween 80
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 327.12
Formula

C13H8Cl2N2O4

CAS No. 50-65-7
Storage powder
in solvent
Synonyms Niclocide

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02807805 Recruiting Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer University of California, Davis|National Cancer Institute (NCI) September 2016 Phase 2
NCT02687009 Not yet recruiting Colon Cancer Michael Morse, MD|Duke University July 2016 Phase 1
NCT02532114 Recruiting Hormone-Resistant Prostate Cancer|Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Adenocarcinoma University of Washington|National Cancer Institute (NCI) December 2015 Phase 1
NCT02519582 Not yet recruiting Colorectal Cancer Charite University, Berlin, Germany|Center for Molecular Medicine August 2015 Phase 2
NCT01296958 Completed Taenia Solium Taeniasis Oregon Health and Science University|Universidad Nacional Mayor de San Marcos|National Institute of Neurological Disorders and Stroke (NINDS) May 2011 --
NCT00138359 Terminated Intestinal Parasitism National Institute of Allergy and Infectious Diseases (NIAID) December 2004 --

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STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID