APTSTAT3-9R

APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.

APTSTAT3-9R Chemical Structure

APTSTAT3-9R Chemical Structure

CAS: no CAS

Selleck's APTSTAT3-9R has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.56%
99.56

APTSTAT3-9R Related Products

Signaling Pathway

Choose Selective STAT Inhibitors

Biological Activity

Description APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.
Targets
STAT3 [1]
(In A549 cells)
In vitro
In vitro APTSTAT3-9R effectively inhibited phosphorylation of STAT3 but did not affect the level of AKT phosphorylation and it suppresses cell viability and proliferation of cancer cells[1].
Cell Research Cell lines A549 cells
Concentrations 0-100 μmol/L
Incubation Time 12 h
Method Cells are plated in a 96-well plate (5,000 cells/well) and incubated for 12 hours. After incubation the cells are treated with nine-arginine (9R), APTSTAT3-9R, and APRscr-9R for 12 hours. After 12 hours incubation, 20 μL MTT (5 mg/mL) is added to each well. After 4 hours, 100 μL dimethyl sulfoxide is added to each well, and absorbance is measured at 570 nm using a Spectra Macplus microplate reader
In Vivo
In vivo APTSTAT3-9R could effectively suppress tumor growth in the in vivo allograft and xenograft tumor models by inhibiting STAT3 phosphorylation[1].
Animal Research Animal Models Human lung carcinoma xenograft model(by subcutaneous implantation of A549 cancer cells into female BALB/c nude mice)
Dosages 8 mg/kg
Administration intratumoral injection

Chemical Information & Solubility

Molecular Weight 4947.51 Formula

C223H330N80O51

CAS No. no CAS SDF Download APTSTAT3-9R SDF
Smiles CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCC(N)=O)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(NC(=O)C(CC5=C[NH]C6=CC=CC=C56)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC7=C[NH]C8=CC=CC=C78)NC(=O)C(NC(=O)C(CC9=C[NH]C%10=CC=CC=C9%10)NC(=O)C(CO)NC(=O)CNC(=O)C%11CCCN%11C(=O)C(CC%12=C[NH]C%13=CC=CC=C%12%13)NC(=O)C(CCC(N)=O)NC(=O)C(CC%14=CC=CC=C%14)NC(=O)CNC(=O)C(N)CC%15=C[NH]C=N%15)C(C)O)C(C)O)C(=O)NC(CCCCN)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(O)=O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy APTSTAT3-9R | APTSTAT3-9R supplier | purchase APTSTAT3-9R | APTSTAT3-9R cost | APTSTAT3-9R manufacturer | order APTSTAT3-9R | APTSTAT3-9R distributor