Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017. Stattic purchased from Selleck.

    LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

  • (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MWXGeY5kfGmxbjDBd5NigQ>? M1nneVEx6oDLzszN M2LmN|TjiImq NFrSdI9z\X[ncoPld{B1cGViZX\m[YN1eyCxZjDJUE0zPw>? NFXYUIIzPjN|OU[zNy=>
NPC  Mn7MSpVv[3Srb36gRZN{[Xl? MlHWNE04NjViwsXN NUXCSnNz[WKxbHnzbIV{KEWPVD3sbYtmKG2xbHXjeYxieiCjbITldoF1cW:wczygZY5lKGOnbHygcYloemG2aX;uJIFv\CCrbo\hd4lwdiCrbnT1Z4VlKGK7IGLLTXAhc26xY3vkc5dv Mo\lNlU6OTV2M{C=
HASMC M{G4ZmZ2dmO2aX;uJGF{e2G7 MmX6NU4zPS13IN88US=> MnvpNlAhdWmw NFPyWIpFVVORwrC= MmTubY5pcWKrdIOgdE0pYSlvU2TBWE0yNDNuNTDzbYdv[Wy|wrC= Mm\VNlU5PDl4MkK=
H9c2  NX3YOIhbTnWwY4Tpc44hSXO|YYm= M4TMOFIwOTBizszN M1LWelIhcA>? NVPoZogxTE2VT9Mg MYrhZpJw\2G2ZYRCpJRp\SCleYTvdJJwfGWldHn2[UBm\m[nY4TzJI9nKEmOLUK3JIFo[Wmwc4SgV2g> MVOyOVgzODlyNx?=
A431 NFjT[nFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX6yxsDPxE1? MofFNuKhcA>? NHnGU2JjdG:la4OgSWdHNXKndnXyd4VlKGSnY4LlZZNmeyCrbjDj[YxtKH[rYXLpcIl1gQ>? NIe1eFkzPTd{MESzOS=>
A431 NWHUbVloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj1bpFLOsLizszN MUiyxsBp NVj4fZJ5cW6lcnXhd4V{KGmwIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNpcWuxbnnu NGTBW3kzPTd{MESzOS=>
SiHa NEDicG9E\WyuIG\pZYJqdGm2eTDBd5NigQ>? MWq1MVc2KG6P MVmyOOKhcMLi NWn3ZWpoe2ixd4OgcY9zeGixbH;nfUBw\iCjIIT5dIlk[WxiYYDvdJRwfGmlIHPlcIwh[W6mIHTvd4Uu\GWyZX7k[Y51KGyxc4Ogc4Yh[2WubDD2bYFjcWyrdIpCpC=> MWiyOVU{QTZ2NB?=
SiHa MoLBSpVv[3Srb36gRZN{[Xl? M3XhOVUuPzVibl2= NU\ET4U{OjUEoHlCpC=> Ml\wdoVlfWOnczD0bIXDqHCqb4PwbI9zgWyjdHnvckBifCC2aHWgeJlzd3OrbnWgdoV{cWS3ZTC3NFXDqA>? NUTveFBXOjV3M{m2OFQ>
ECA109 NXniZnVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrHb2ZxOC1{MDFOwG0> MkXyNlTDqGkEoB?= NYq2b4lFUUN3ME21MlUxKM7:TR?= MYqyOVQ6OjR6MB?=
TE13 NE\GUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjybmtTOC1{MDFOwG0> MlezNlTDqGkEoB?= MojFTWM2OD14LkG1xsDPxE1? NILRWYozPTR7MkS4NC=>
KYSE150  NYKwW2F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojmNE0zOCEQvF2= M120TlI1yqCqwrC= M2T1fGlEPTB;MUKuOlTDqM7:TR?= M4CwblI2PDl{NEiw
ECA109 M1PLSWNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= NVHxRWk2OC53wrFOwG0> MW[yOOKhcMLi NUjKWIU1e3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> NF24bIQzPTR7MkS4NC=>
TE13 NI\xWY9EdG:wb3flcolkKFO3co\peoFtKEG|c3H5 MYewMlXDqM7:TR?= MXyyOOKhcMLi MXfzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= NXH0RXNTOjV2OUK0PFA>
KYSE150  MkDRR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= NVy5NIJEOC53wrFOwG0> M1rsdlI1yqCqwrC= NYXEOmFve3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> NXi1WndyOjV2OUK0PFA>
ECA109 M2\ib2Z2dmO2aX;uJGF{e2G7 M{PUVlAvPcLizszN M2X3cFI1yqCqwrC= Mk[4[Y5p[W6lZYOgTXIucW6mdXPl[EBo\W6ncnH0bY9vKG:oIFTTRpM> MXyyOVQ6OjR6MB?=
PC3M-1E8 MVLGeY5kfGmxbjDBd5NigQ>? MUiyMlUwPS9zMDFOwG0> NYTOfIVzOC12IHi= NWj3d3IzcW6qaXLpeJMhfGinIGPURXQ{KGGldHn2ZZRqd25iaX6gZUBld3OnLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{wrC= M2L6WFI2OjZzM{[1
PC3M-1E8 NXTVbZdXTnWwY4Tpc44hSXO|YYm= MofMNVAh|ryP MknxNlQhcA>? M4K3UYRwf26{ZXf1cIF1\XNiQnPsMZhNNCC|dYL2bZZqdiCjbnSgZ{1OgWN? MlvQNlUzPjF|NkW=
PC3M-1E8 M3jZfGZ2dmO2aX;uJGF{e2G7 NIPIV24yOCEQvF2= NVu1TYhtOjRiaB?= MXzpcohq[mm2czDJUE03KGmwZIXj[YQhW1SDVEOgZYN1cX[jdHnvckBidmRidHjlJGlNNTZvaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9v M3\nWlI2OjZzM{[1
PC3M-1E8 M3;3emNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= MlfVNk42NzVxMUCg{txO Mk[3bY5pcWKrdIRCpJRp\SClb3zvcpkh\m:{bXH0bY9vKHOrZ37p[olk[W62bIm= M3PmXFI2OjZzM{[1
MDA-MB-231 NWO4UoZSTnWwY4Tpc44hSXO|YYm= NVHLSIJVOjBizszN NFrLWIMzKGh? MYLlfIhq[mm2czDTcoFqdCCjbnSgSU1k[WSqZYLpckBmgHC{ZYPzbY9v NUj3SGRNOjVzNUOzOFk>
H9c2 MWLGeY5kfGmxbjDBd5NigQ>? MXqyNEDDvU1? NFPSVnI{OCCvaX6= MVPEUXNQyqB? Mor4ZYJwdGm|aHXzJJBzd3CxZn;sMYlv\HWlZXSgRWtVKHCqb4PwbI9zgWyjdHnvckBifCCkb4ToJJNmejR5MzDhcoQhfGi{M{C4 NWHUdZpxOjVzMEWwOlc>
HaCaT  M3fnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH2ybYsyOCEEtV2= M2WwcVIxKG2rbh?= M37nWWROW00EoB?= MVPlcohidmOnczDzc5Ji\mWwaXKtJIFv\CC|dX7peIlvcWJvaX7keYNm\CCpcn;3eIghcW6qaXLpeIlwdg>? M4jtNVI2ODF|OUC3
Caki-1 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljvNVAhyrWP NXLlUHRsOjBibXnu MojWSG1UV8Li MX;lcohidmOnczDzc5Ji\mWwaXKtJIFv\CC|dX7peIlvcWJvaX7keYNm\CCpcn;3eIghcW6qaXLpeIlwdg>? Ml\0NlUxOTN7MEe=
HaCaT  MorBRZBweHSxc3nzJGF{e2G7 M3XaRlExKML3TR?= Mn3DNlAhdWmw MlS3SG1UV8Li NHXKVZVqdmO{ZXHz[ZMheHKxcH;yeIlwdnNib3[gZZBweHSxdHnjJINmdGy|IHT1[UB1dyC2cnXheI1mdnRid3n0bEB{d3KjZnXubYIhd3Jic4XubZRqdmmk NG\mdXEzPTBzM{mwOy=>
FHL-primed hNSCs NEDU[YdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MUiwMlAzNTVizszN NFOwelA4OiCq NI[zdI5t\WGmczD0c{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBifCCqaXfoJINwdmOnboTyZZRqd25? M4PMN|I1QTR3NEO0
ELL-primed hNSCs MUfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NYHWT|k3OC5yMj21JO69VQ>? M3ridVczKGh? MliycIVi\HNidH:geIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZZQhcGmpaDDjc45k\W62cnH0bY9v NX23UG1ZOjR7NEW0N|Q>
SS NH3mOoNE\WyuIG\pZYJqdGm2eTDBd5NigQ>? Ml7FNU0yOCEQvF2= M{DGR|czKGh? MnOwSG1UVw>? MXnjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= NGnEUXUzPDd3NkGxNS=>
SeAx  Ml\5R4VtdCCYaXHibYxqfHliQYPzZZk> NFq5e5cyNTFyIN88US=> NUT0[WdrPzJiaB?= NF7STodFVVOR MnnIZ4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= MUiyOFc2PjFzMR?=
HuT-78 MnfWR4VtdCCYaXHibYxqfHliQYPzZZk> NEfCZYwyNTFyIN88US=> MnLFO|IhcA>? MXjEUXNQ M4HHZYNifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg NXvqe3pVOjR5NU[xNVE>
CD4+ M2f3ZmFxd3C2b4Ppd{BCe3OjeR?= MkPtNVDjiIoQvH2= NHzoU3ozPCCq MVLEUXNQ MlvibY5lfWOnczDhdI9xfG:|aYOgd5Rzd26pbIm= M3PtTlI1PzV4MUGx
MCF-7 MorES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWiwMlQ3QS1|Lke1JO69VQ>? MXG1JIQ> MkPadoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 NF3IU|kzPDd{OEC3PC=>
MCF-7/LCC1 NGj2UoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojsNE41PjlvMz63OUDPxE1? NVPaTFkxPSCm MknLdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 M1XCR|I1PzJ6MEe4
MCF-7/LCC9 NWfuXFdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVewMlQ3QS1|Lke1JO69VQ>? NWfqNIs5PSCm NUi0SXp2emWmdXPld{Bk\WyuIH71cYJmeiC|aXfubYZq[2GwdHz5 NY\jWnNnOjR5MkiwO|g>
HaCaT NGH5UoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvlXXIyOCEEtV2= M3GwNlIxKG2rbh?= MUjEUXNQyqB? MlK0[Y5p[W6lZYOg[ZZmem:uaX31d{1qdmS3Y3XkJINmdGxiZ4Lve5RpKGmwaHnibZRqd25? MYKyOFQzOzF|MR?=
HaCaT M{ezVGFxd3C2b4Ppd{BCe3OjeR?= NICy[3MyOCEEtV2= MXeyNEBucW5? NUL4eJdkTE2VT9Mg NFXrc3BmdmijbnPld{B1cGViYYDvdJRwfGmlIHXm[oVkfHNib3[g[ZZmem:uaX31dy=> NWXsPZcxOjR2MkOxN|E>
MDA-MB-231 M37rV2Z2dmO2aX;uJGF{e2G7 NUXzRo1xOTBiwsXN NVfIPXZYOjRiaB?= NVXwRmo5TE2VT9Mg M{L2W5Jm\HWlZYOgVE1UXEGWMzDlfJBz\XO|aX;u M4Hw[|I1Ozd4NUi2
SUM-159 NUPB[216TnWwY4Tpc44hSXO|YYm= NUK4R4liOTBiwsXN NYLRcGFUOjRiaB?= MWrEUXNQyqB? MmO2doVlfWOnczDQMXNVSVR|IHX4dJJme3Orb36= NVPLPZpXOjR|N{[1PFY>
SK-BR-3 M2XwSmZ2dmO2aX;uJGF{e2G7 M3yzWVExKML3TR?= NI[1Z5EzPCCq NV;4Noo6TE2VT9Mg NIfx[GRz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> NIXwfoMzPDN5NkW4Oi=>
MCF7-HER2 MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm1PZZ2OC1zMDFOwG0> NWn5OWhwPDhiaB?= NH7Ce5NFVVOR MnXRbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= M1rYdFI1Ojl5NUC4
MCF7-HER2 M3;WNGZ2dmO2aX;uJGF{e2G7 M2XwcFUh|ryP MUSyOEBp M1;DTmROW09? M3;1dIRqdWmwaYPo[ZMhW2:6LUKsJG9kfC12LDDhcoQhe2y3ZzDlfJBz\XO|aX;u MkLvNlQzQTd3MEi=
MCF7-HER2 MV7GeY5kfGmxbjDBd5NigQ>? MlP3OUDPxE1? M3TPelI1KGh? NEDMWmtFVVOR NGXsXIFl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wy|IH;mJGVOXCCvYYLr[ZJ{NCC4aX3lcpRqdiCjbnSgd4x2\w>? MnnQNlQzQTd3MEi=
MCF7-HER2 MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn61OUDPxE1? M1zsZlI1KGh? MnfzSG1UVw>? M3\O[IVvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iY3;tZolv\WRid3n0bEBJ\XKlZYD0bY4> MVuyOFI6PzVyOB?=
HMECs  M{nudGZ2dmO2aX;uJGF{e2G7 MYCxNEDPxE1? MYqyJIg> MYnpcohq[mm2czDJSm7PucLibXXkbYF1\WRicHjvd5Bpd3K7bHH0bY9vKG:oIGPURXQyNCCVVFHUNkBidmRiU2TBWFM> NXqwb3lmOjR{MUGzNlc>
HTR8/SVneo MnXlSpVv[3Srb36gRZN{[Xl? MnvyNeKh|ryPwrC= MUWxxsBp MWPzeZBxemW|c3XkJG9UVS2rbnT1Z4VlKFOWQWSzJJBpd3OyaH;yfYxifGmxbh?= MmTFNlQxPjB{NEG=
HTR8/SVneo MY\GeY5kfGmxbjDBd5NigQ>? MXewMlUwOcLizszNxsA> NEW5S5A1QCCq Ml\1doV{fG:{ZYOgeIhmKGW6cILld5Nqd25ib3[gSU1k[WSqZYLpckB{fXCycnXzd4VlKGK7IF;TUS=> NVLsd|RlOjRyNkCyOFE>
HTR8/SVneo MYjGeY5kfGmxbjDBd5NigQ>? M3;sPFHDqM7:TdMg MlW0OFghcA>? MX;zbYdvcW[rY3HueIx6KGmwY4LlZZNmeyCvaXfyZZRqd25iYomgU3NOyqB? M4i0blI1ODZyMkSx
C13* MYHBdI9xfG:|aYOgRZN{[Xl? MoPBNE0yOCEQvF2= NUDMZZJHOjRxNEigbC=> M1T3SIlv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy MWqyN|k3OjV3OB?=
OV2008 MmHFRZBweHSxc3nzJGF{e2G7 NFThWFIxNTFyIN88US=> MkDVNlQwPDhiaB?= MWTpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3WgZY5lKHSrbXWg[IVx\W6mZX70JI1idm6nch?= MmLqNlM6PjJ3NUi=
C13* NF21dG5CeG:ydH;zbZMhSXO|YYm= NHy3XXUzPC92ODDo MVPlcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= M{XRN|I{QTZ{NUW4
OV2008 M4HqfWFxd3C2b4Ppd{BCe3OjeR?= NX7wZ|dDOjRxNEigbC=> MnrJ[Y5p[W6lZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZZBweHSxc3nz NUDCPXRqOjN7NkK1OVg>
W480  MYTGeY5kfGmxbjDBd5NigQ>? MoTYNk42NzFyIN88US=> NVvDSY9lOzBibXnu MWPEUXNQ NYLh[nZse2Wwc3n0bZpmeyClZXzsd{B1dyClaHXtc5Ji\GmxdHjldoFxgSCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MVuyN|k{PDl5Mh?=
SW837 MWDGeY5kfGmxbjDBd5NigQ>? NX:zUHk{Oi53L{GwJO69VQ>? MX6zNEBucW5? M37tXWROW09? M{LBTZNmdnOrdHn6[ZMh[2WubIOgeI8h[2inbX;yZYRqd3SqZYLhdJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MWqyN|k{PDl5Mh?=
T24 NHXDZYZHfW6ldHnvckBCe3OjeR?= MWWyM|ExNzJyIN88US=> MVKyOEBp MoLzZ4F2e2W|IHTvd4Uu\GWyZX7k[Y51KGmwaHnibZRqd25ib3[geIhmKEO[Q1yxNk1qdmS3Y3XkJIlv[3KnYYPlJI9nKGmwdnHkbY5oKGOnbHzz MXGyN|UzPjB5OR?=
CNE1 MYLGeY5kfGmxbjDBd5NigQ>? MVKyNEDDvU1? MorrOFghcA>? NUT2XHU{[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NGjOVVAzOzN6MkmxOC=>
CNE2 NIfXc5RHfW6ldHnvckBCe3OjeR?= MljqNlAhyrWP M{\VZlQ5KGh? NXXM[2N4[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NXn6VmF1OjN|OEK5NVQ>
HONE1 NUnoTJpJTnWwY4Tpc44hSXO|YYm= NHns[ZozOCEEtV2= MXO0PEBp MYLicI9kc3NidHjlJGlNNTZiaX7jdoVie2WmIIDoc5NxcG:{eXzheIlwdiCxZjDTeIF1Ow>? M1y3[VI{Ozh{OUG0
CNE1 NV7hXo1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz6W|Y1KM7:TR?= M4XZVpNq\26rZnnjZY51dHlicnXkeYNmeyClZXzsJJZq[WKrbHn0fS=> M1m5N|I{Ozh{OUG0
CNE1 NGm5OVdHfW6ldHnvckBCe3OjeR?= MV[wMVIxKM7:TR?= M1r2dVAuPCCq NU\SR|BScW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> MVuyN|M5OjlzNB?=
CNE2 NWqwV2RXTnWwY4Tpc44hSXO|YYm= Ml\oNE0zOCEQvF2= MoW0NE01KGh? MofZbY5pcWKrdIOgV5RifDNiYXP0bZZifGmxbjDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NGXRT3MzOzN6MkmxOC=>
HONE1 MkH4SpVv[3Srb36gRZN{[Xl? Ml\nNE0zOCEQvF2= NEj3OmExNTRiaB?= NX;seI1xcW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> MnnBNlM{QDJ7MUS=
CNE1 M3W1UmNmdGxiVnnhZoltcXS7IFHzd4F6 NET5dJgxNjVvNkSg{txO M{fSTFQ5KGh? MUDzeZBxemW|c3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= M3Ho[VI{Ozh{OUG0
CNE2 M2S3[mNmdGxiVnnhZoltcXS7IFHzd4F6 M134flAvPS14NDFOwG0> M1vkO|Q5KGh? Ml7xd5VxeHKnc4Pld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= M3X4XlI{Ozh{OUG0
HONE1 MVjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2C5VVAvPS14NDFOwG0> M3rJN|Q5KGh? NFnoT|F{fXCycnXzd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> MoX1NlM{QDJ7MUS=
C666-1  NEXJPVdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MUWwMlUuPjRizszN M4T1fVQ5KGh? M2O1N5N2eHC{ZYPz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy M2\kSlI{Ozh{OUG0
CNE1 NG\MbopCeG:ydH;zbZMhSXO|YYm= NWf6V5R3OTBiwsXNxsA> MnfzOFghcA>? NU\2TnY6cW6mdXPld{BieG:ydH;zbZPDqA>? MmLTNlM{QDJ7MUS=
CNE2 MV;BdI9xfG:|aYOgRZN{[Xl? NGLmbGsyOCEEtV5CpC=> NInnbII1QCCq MYDpcoR2[2W|IHHwc5B1d3Orc9Mg MVGyN|M5OjlzNB?=
HONE1 Ml7hRZBweHSxc3nzJGF{e2G7 M4HWelExKML3TdMg MUC0PEBp M2DQc4lv\HWlZYOgZZBweHSxc3nzxsA> NFzsSoMzOzN6MkmxOC=>
CNE2 NF3WWIxE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MoX6NU8zKM7:TR?= M4rXdlQ5KGh? Mke0d4Vve2m2aYrlJINmdGy|IITvJJJi\GmxdHjldoFxgQ>? MUKyN|M5OjlzNB?=
HONE1 NGrr[IJE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NVPSUppMOS9{IN88US=> NI[1WGs1QCCq NUjBbHk2e2Wwc3n0bZpmKGOnbHzzJJRwKHKjZHnveIhmemGyeR?= MmPBNlM{QDJ7MUS=
C666-1  MY\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MlqzNU8zKM7:TR?= NUe2NJE5PDhiaB?= MmCzd4Vve2m2aYrlJINmdGy|IITvJJJi\GmxdHjldoFxgQ>? MkSwNlM{QDJ7MUS=
HEC-1A MY\GeY5kfGmxbjDBd5NigQ>? M2jX[FHDqM7:TdMg MnSxNlQhcA>? MWDEUXNQ MkLNZoxw[2u|IITo[UBOXUN{MD3lcohidmOnZDDpcpZie2mxbjD0dolo\2W{ZXSgZpkhOTBnIF\CVy=> NIfDOogzOzJ4MkKwPC=>
RL95-2 M1L0WWZ2dmO2aX;uJGF{e2G7 M3n6WVHDqM7:TdMg M3fmPVI1KGh? MXfEUXNQ NUnaTod7[myxY3vzJJRp\SCPVVOyNE1mdmijbnPl[EBqdn[jc3nvckB1emmpZ3Xy[YQh[nliMUClJGZDWw>? MVOyN|I3OjJyOB?=
HEC-1A MWjGeY5kfGmxbjDBd5NigQ>? NX3SWWlkOcLizszNxsA> MlSwNlQhcA>? NFXIOYFFVVOR NF\2dWxjdG:la4OgeIhmKE2XQ{KwMYVvcGGwY3XkJIlvfmG|aX;uJJRzcWepZYLl[EBjgSCHR1dCpC=> NIG1enczOzJ4MkKwPC=>
RL95-2 M37DSGZ2dmO2aX;uJGF{e2G7 MkHsNeKh|ryPwrC= NV\5NYxkOjRiaB?= M3XNV2ROW09? MYricI9kc3NidHjlJG1WSzJyLXXubIFv[2WmIHnueoF{cW:wIITybYdo\XKnZDDifUBGT0cEoB?= MWWyN|I3OjJyOB?=
CT26 M1ewRWZ2dmO2aX;uJGF{e2G7 MX[yNEBuVQ>? NWf3dWp[OSCq MXPzeZBxemW|c3XzJGhITi2rbnT1Z4VlKF[HR1[g[ZhxemW|c3nvcuKh NX\xc3I5OjN{M{OxOlM>
UM-SCC-17B NHTm[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTmeGcxUUN3ME2yMlU3OiEEsTCwMlQxQSEQvF2sJGdKPTB;MT6yO|khyrFiMD6xPVQh|ryP NV\UUYFVOjJ5N{C4PVk>
OSC-19 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPnWpBKSzVyPUOuOFgyKMLzIECuPVU{KM7:TTygS2k2OD1zLkO2OkDDuSByLke3NEDPxE1? MnzENlI4PzB6OUm=
Cal33 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF70SlJKSzVyPUKuNlgzKMLzIECuOFI{KM7:TTygS2k2OD1zLkO0PUDDuSByLkO2N{DPxE1? NUHuPFFqOjJ5N{C4PVk>
UM-SCC-22B MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO4TWM2OD1{Lk[0PEDDuSByLkW0NkDPxE1uIFfJOVA:OS5|MkCgxtEhOC5{MESg{txO NVrSVId7OjJ5N{C4PVk>
UM-SCC-17B Mom3SpVv[3Srb36gRZN{[Xl? NEfCPWQxNTNyIN88US=> NVj4ZVVsOC1{NDDo NXnnRm97cW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 M364ZVIzPzdyOEm5
OSC-19 NED1dVRHfW6ldHnvckBCe3OjeR?= MVOwMVMxKM7:TR?= M2X6PFAuOjRiaB?= MmrIbY5pcWKrdIOgV3RCXDNiYXP0bZZifGmxbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfGy7 NH\0bVQzOjd5MEi5PS=>
Cal33 Mn;HSpVv[3Srb36gRZN{[Xl? M1y0PVAuOzBizszN M1TsUFAuOjRiaB?= NXnjVotpcW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 M2jiUFIzPzdyOEm5
UM-SCC-22B MnG3SpVv[3Srb36gRZN{[Xl? M3vVbVAuOzBizszN NUjSclNIOC1{NDDo NYrFWWN1cW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 MmjxNlI4PzB6OUm=
U-87MG NUn2XFk4S2WubDDWbYFjcWyrdImgRZN{[Xl? NEPkeFcxNTFyIN88US=> NWjIOnlXPzJiaB?= M4Dob2ROW09? M2O3UIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NX:wUWFwOjV2M{[2PFI>
U-373MG NUjGRoFrS2WubDDWbYFjcWyrdImgRZN{[Xl? MlS3NE0yOCEQvF2= MWC3NkBp NVq0OZpjTE2VTx?= MoXmbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? MnzVNlU1OzZ4OEK=
SH-SY5Y NWKzNGJbS2WubDDWbYFjcWyrdImgRZN{[Xl? M2LPfFAuOTBizszN MonaO|IhcA>? M3y5cmROW09? NF\NeGpqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 MVqyOVQ{PjZ6Mh?=
Tu-9648 M3OyVWNmdGxiVnnhZoltcXS7IFHzd4F6 MonpNE0yOCEQvF2= MljtO|IhcA>? NIrFbnNFVVOR MV;pcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MViyOVQ{PjZ6Mh?=
Neuro-2a NU[1VJN[S2WubDDWbYFjcWyrdImgRZN{[Xl? NXfLV3pjOC1zMDFOwG0> M3fiTFczKGh? NXvYc|RVTE2VTx?= MUXpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 NGm0Z|czPTR|Nk[4Ni=>
PCNs MV3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NUD5ZWNtOC1zMDFOwG0> NUnHSWJMPzJiaB?= NYPSU3VvTE2VTx?= NHXzdIVqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 Mn3CNlU1OzZ4OEK=
PGCs M3T5ZWNmdGxiVnnhZoltcXS7IFHzd4F6 NFPPN5AxNTFyIN88US=> MUi3NkBp MV3EUXNQ NHjDUoJqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 MVmyOVQ{PjZ6Mh?=
RAW264.7 M1LqWmZ2dmO2aX;uJGF{e2G7 M1vnNFExKM7:TR?= MXuxNkBp NYO5Vms{[WK{b3fheIV{KHSqZTDtVm5CKGW6cILld5Nqd26|IH;mJGpCUzJuIGPURXQyNCCVVFHUNkwh[W6mIGPURXQ{KGmwZIXj[YQh[nliRF;OJIFv\CCWLUKgeI95cW5? NGLrblQzOjR3NESzNS=>
RAW264.7 NFLGOnVCeG:ydH;zbZMhSXO|YYm= M2PMT|UwOTBizszN M1TsclQ2KG2rbh?= NU\6TVV7\W6qYX7j[ZMhfG:6aX7zJIlv\HWlZXSgZZBweHSxc3nzJIFv\CCPTWCgcI9{ew>? NU\XZXMzOjJ2NUS0N|E>
SW480 MlnmR4VtdCCYaXHibYxqfHliQYPzZZk> NEXsSHE2NzFyL{KwJO69VQ>? M1K4XVczKGh? MoXubY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? NV6xb|ZPOjF7MECzPVc>
HCT116 MULD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NX3pbJJOPS9zMD:yNEDPxE1? MVO3NkBp M372W4lvcGmkaYTzJINmdGxidnnhZoltcXS7IH;mJJRp\SCDTFTIL{9ETDF|MzxCpINmdGy| M1f5eVIyQTByM{m3
DLD-1  M{XEXmNmdGxiVnnhZoltcXS7IFHzd4F6 MlPCOU8yOC9{MDFOwG0> MVW3NkBp NWTHOlBKcW6qaXLpeJMh[2WubDD2bYFjcWyrdImgc4YhfGinIFHMSGgsN0OGMUOzL:Kh[2WubIO= NFz2fWIzOTlyMEO5Oy=>
SNU387  M3\DSGNmdGxiVnnhZoltcXS7IFHzd4F6 M2Li[|IxyqEQvF5CpC=> NFXSZ|UzPCCq M1rlO5Jm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MW[yNVMyOTl5NR?=
SNU398 M1n6TWNmdGxiVnnhZoltcXS7IFHzd4F6 NVrlb3l2OjEEoN88UeKh M3vOUlI1KGh? M2Gwb5Jm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MmGwNlE{OTF7N{W=
HepG2 NVv0fo54S2WubDDWbYFjcWyrdImgRZN{[Xl? NXe1XYlLOjEEoN88UeKh M1rMNFI1KGh? M3nDUJJm\HWlZYOgZ4VtdCC4aXHibYxqfHl? NHvzXIszOTNzMUm3OS=>
Huh-7 M3\FOGNmdGxiVnnhZoltcXS7IFHzd4F6 M4POZVIxyqEQvF5CpC=> MnT6NlQhcA>? MUHy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 M3XnNlIyOzFzOUe1
VSMC NWGxUWhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[ydY5VOy93L{GwJO69VQ>? NHq0S4I{OCCvaX6= NYfXZlhnTE2VTx?= M2DOPZBz\X[nboTzJHBFT0ZvIHHu[EB1cHKxbXLpck1u\WSrYYTl[EBXW02FIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> Ml6yNlA5PDd|ME[=
MDA-MB-231 M37NUmFxd3C2b4Ppd{BCe3OjeR?= M1vFPVExKM7:TR?= M1XYb|I1KGh? M3jE[WROW00EoB?= NFrXOWVqdmS3Y3XzJIFxd3C2b4Ppdy=> MXKxO|EyPDByNR?=
MDA-MB-435S NVT1TnFESXCxcITvd4l{KEG|c3H5 NELnWo0yOCEQvF2= M1HST|I1KGh? M3SxXWROW00EoB?= M{fHTolv\HWlZYOgZZBweHSxc3nz MlLSNVcyOTRyMEW=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+H2O
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

Related STAT Products

Tags: buy Stattic | Stattic supplier | purchase Stattic | Stattic cost | Stattic manufacturer | order Stattic | Stattic distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID