Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017, 7:41404. Stattic purchased from Selleck.

    LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

  • (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 M1LhXWZ2dmO2aX;uJGF{e2G7 NXPUfXFWOTEkgJpOwG0> NGnicms16oDLaB?= MmXNdoV3\XK|ZYOgeIhmKGWoZnXjeJMhd2ZiSVytNlc> NILWclUzPjN|OU[zNy=>
NPC  Ml\ISpVv[3Srb36gRZN{[Xl? MXywMVcvPSEEtV2= MX;hZo9tcXOqZYOgSW1VNWyra3WgcY9t\WO3bHHyJIFtfGW{YYTpc45{NCCjbnSgZ4VtdCCvaXfyZZRqd25iYX7kJIlvfmG|aX;uJIlv\HWlZXSgZpkhWkuLUDDrco9kc2Sxd36= NX\OVHJJOjV7MUW0N|A>
HASMC MWjGeY5kfGmxbjDBd5NigQ>? NV\6SGlmOS5{NT21JO69VQ>? NVS3O5JGOjBibXnu MYnEUXNQyqB? Ml7YbY5pcWKrdIOgdE0pYSlvU2TBWE0yNDNuNTDzbYdv[Wy|wrC= NFnPTnQzPTh2OU[yNi=>
H9c2  NYLpcJdFTnWwY4Tpc44hSXO|YYm= MYmyM|ExKM7:TR?= NH:xV4MzKGh? NUTRT2xHTE2VT9Mg MlfhZYJzd2ejdHXzxsB1cGViY4n0c5Bzd3SnY4TpeoUh\W[oZXP0d{Bw\iCLTD2yO{Bi\2GrboP0JHNJ NWjKWphNOjV6MkC5NFc>
A431 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLKOopjOsLizszN NUTW[mNWOsLiaB?= NHLwPFhjdG:la4OgSWdHNXKndnXyd4VlKGSnY4LlZZNmeyCrbjDj[YxtKH[rYXLpcIl1gQ>? M3LFZVI2PzJyNEO1
A431 MkTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn2RYczyqEQvF2= M1nycVLDqGh? NWXNUmI5cW6lcnXhd4V{KGmwIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNpcWuxbnnu NVP0SpkyOjV5MkC0N|U>
SiHa MlfzR4VtdCCYaXHibYxqfHliQYPzZZk> M2OzXlUuPzVibl2= MkXuNlTDqGkEoB?= M2PDbZNpd3e|IH3vdpBpd2yxZ4mgc4Yh[SC2eYDpZ4FtKGGyb4D0c5Rq[yClZXzsJIFv\CCmb4PlMYRmeGWwZHXueEBtd3O|IH;mJINmdGxidnnhZoltcXS7wrC= M3jnWlI2PTN7NkS0
SiHa MlXHSpVv[3Srb36gRZN{[Xl? M3\XWFUuPzVibl2= NYXlUnJTOjUEoHlCpC=> M2Hib5Jm\HWlZYOgeIhmyqCyaH;zdIhwenmuYYTpc44h[XRidHjlJJR6em:|aX7lJJJme2mmdXWgO|A2yqB? Ml3vNlU2Ozl4NES=
ECA109 NW\4UVA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D5NlAuOjBizszN MmC5NlTDqGkEoB?= M2q4c2lEPTB;NT61NEDPxE1? MkXoNlU1QTJ2OEC=
TE13 NF\qdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTPNE0zOCEQvF2= MmjNNlTDqGkEoB?= MYDJR|UxRTZwMUZCpO69VQ>? MXGyOVQ6OjR6MB?=
KYSE150  MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzvbIV4OC1{MDFOwG0> MXmyOOKhcMLi M{PJfWlEPTB;MUKuOlTDqM7:TR?= NX7mc5gyOjV2OUK0PFA>
ECA109 MonDR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= MoDCNE42yqEQvF2= NH\HR4MzPMLiaNMg MXvzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= NVTyN49IOjV2OUK0PFA>
TE13 NI\BbZVEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 Mm\wNE42yqEQvF2= NXzC[FFlOjUEoHlCpC=> MnTxd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= NW\TO|E6OjV2OUK0PFA>
KYSE150  MXjDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 NFHrR3UxNjYEoN88US=> NH3oc|IzPMLiaNMg MX3zeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= NXnI[pNHOjV2OUK0PFA>
ECA109 MWLGeY5kfGmxbjDBd5NigQ>? NIXQd|cxNjYEoN88US=> MWmyOOKhcMLi NWrkNJIx\W6qYX7j[ZMhUVJvaX7keYNm\CCpZX7ldoF1cW:wIH;mJGRUSnN? MYOyOVQ6OjR6MB?=
PC3M-1E8 NULZTHl2TnWwY4Tpc44hSXO|YYm= MV:yMlUwPS9zMDFOwG0> NF75T5QxNTRiaB?= MnThbY5pcWKrdIOgeIhmKFOWQWSzJIFkfGm4YYTpc44hcW5iYTDkc5NmNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVzyqB? M375cVI2OjZzM{[1
PC3M-1E8 M2nmZmZ2dmO2aX;uJGF{e2G7 MnzINVAh|ryP NVX5TIZKOjRiaB?= M{DUN4Rwf26{ZXf1cIF1\XNiQnPsMZhNNCC|dYL2bZZqdiCjbnSgZ{1OgWN? M{T1R|I2OjZzM{[1
PC3M-1E8 M{m1TGZ2dmO2aX;uJGF{e2G7 M1zyelExKM7:TR?= MoSwNlQhcA>? NVfuOJJGcW6qaXLpeJMhUUxvNjDpcoR2[2WmIGPURXQ{KGGldHn2ZZRqd25iYX7kJJRp\SCLTD22MYlv\HWlZXSgV3RCXDNiYXP0bZZifGmxbh?= M4\uSVI2OjZzM{[1
PC3M-1E8 NFPjT49EdG:wb3flcolkKFO3co\peoFtKEG|c3H5 M{fhUFIvPS93L{GwJO69VQ>? Mk\ZbY5pcWKrdIRCpJRp\SClb3zvcpkh\m:{bXH0bY9vKHOrZ37p[olk[W62bIm= MUWyOVI3OTN4NR?=
MDA-MB-231 NH3VW3lHfW6ldHnvckBCe3OjeR?= MmDINlAh|ryP NFTjemwzKGh? NFS0NJFmgGirYnn0d{BUdmGrbDDhcoQhTS2lYXTo[ZJqdiCneIDy[ZN{cW:w M1XyfFI2OTV|M{S5
H9c2 NFPJV41HfW6ldHnvckBCe3OjeR?= MUCyNEDDvU1? MkOyN|AhdWmw NHK3fYdFVVORwrC= M4X1VIFjd2yrc3jld{Bxem:yb3\vcE1qdmS3Y3XkJGFMXCCyaH;zdIhwenmuYYTpc44h[XRiYn;0bEB{\XJ2N{OgZY5lKHSqckOwPC=> MkTlNlUyODVyNke=
HaCaT  M1f5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYixNEDDvU1? NYnlXoc5OjBibXnu MnrrSG1UV8Li NE\Y[G5mdmijbnPld{B{d3KjZnXubYIuKGGwZDDzeY5qfGmwaXKtbY5lfWOnZDDndo94fGhiaX7obYJqfGmxbh?= NYCyUoJWOjVyMUO5NFc>
Caki-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mof3NVAhyrWP MUiyNEBucW5? MmK3SG1UV8Li MXvlcohidmOnczDzc5Ji\mWwaXKtJIFv\CC|dX7peIlvcWJvaX7keYNm\CCpcn;3eIghcW6qaXLpeIlwdg>? NV;vdmhJOjVyMUO5NFc>
HaCaT  M1fhWmFxd3C2b4Ppd{BCe3OjeR?= MUCxNEDDvU1? NHO3Z|IzOCCvaX6= NE\XfpBFVVORwrC= MlrqbY5kemWjc3XzJJBzd3CxcoTpc45{KG:oIHHwc5B1d3SrYzDj[YxteyCmdXWgeI8hfHKnYYTt[Y51KHerdHigd49z[W[nbnniJI9zKHO3bnn0bY5q[g>? M3XySVI2ODF|OUC3
FHL-primed hNSCs Mm\sR4VtdCCYaXHibYxqfHliQYPzZZk> M124e|AvODJvNTFOwG0> MmrxO|IhcA>? M2TUWYxm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? M{TrV|I1QTR3NEO0
ELL-primed hNSCs Ml\JR4VtdCCYaXHibYxqfHliQYPzZZk> NWXD[ZFmOC5yMj21JO69VQ>? NF:xRXQ4OiCq M4TMdoxm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? MXyyOFk1PTR|NB?=
SS Mn7kR4VtdCCYaXHibYxqfHliQYPzZZk> MmfDNU0yOCEQvF2= NVqxeWFlPzJiaB?= NH[w[GJFVVOR MljIZ4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= NEj5fIMzPDd3NkGxNS=>
SeAx  M3zNUmNmdGxiVnnhZoltcXS7IFHzd4F6 NYn1bmczOS1zMDFOwG0> NHL1VGY4OiCq NXOzd2VJTE2VTx?= NH3ycVFk[XW|ZYOgZUBld3OnLXTldIVv\GWwdDDpcohq[mm2aX;uJI9nKHSqZTD2bYFjcWyrdIpCpC=> M1HkUlI1PzV4MUGx
HuT-78 Mlv1R4VtdCCYaXHibYxqfHliQYPzZZk> MXyxMVExKM7:TR?= NHzVV484OiCq NWHSbYR[TE2VTx?= NYH3PXhr[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> NVv0dIZCOjR5NU[xNVE>
CD4+ NGnQZWZCeG:ydH;zbZMhSXO|YYm= M3K0OFEx6oDLzszt NX7lO2Z5OjRiaB?= NX\Vc49pTE2VTx?= NXrwRmFRcW6mdXPld{BieG:ydH;zbZMhe3S{b37ncJk> M2\XPFI1PzV4MUGx
MCF-7 NWXpUphNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL4NE41PjlvMz63OUDPxE1? MXG1JIQ> M1HPUJJm\HWlZYOgZ4VtdCCwdX3i[ZIhe2mpbnnmbYNidnSueR?= NWLVOHdoOjR5MkiwO|g>
MCF-7/LCC1 NWPKZXE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XOc|AvPDZ7LUOuO|Uh|ryP M4[xe|Uh\A>? NHPIOFBz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= M{\SOlI1PzJ6MEe4
MCF-7/LCC9 M2fuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSwMlQ3QS1|Lke1JO69VQ>? M{TYU|Uh\A>? Mo\CdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MmqwNlQ4OjhyN{i=
HaCaT Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGxNEDDvU1? MUWyNEBucW5? M4\zWGROW00EoB?= NUSwR4k1\W6qYX7j[ZMh\X[ncn;sbY12ey2rbnT1Z4VlKGOnbHyg[5Jwf3SqIHnubIljcXSrb36= NEXqNmUzPDR{M{GzNS=>
HaCaT MWDBdI9xfG:|aYOgRZN{[Xl? MWixNEDDvU1? M1PV[lIxKG2rbh?= NEK4SlVFVVORwrC= MlfQ[Y5p[W6lZYOgeIhmKGGyb4D0c5Rq[yCnZn\lZ5R{KG:oIHX2[ZJwdGmvdYO= M1rXeFI1PDJ|MUOx
MDA-MB-231 M2DEcmZ2dmO2aX;uJGF{e2G7 M16xbVExKML3TR?= NH[3XIUzPCCq NH22bI1FVVORwrC= NVHYW5R{emWmdXPld{BRNVOWQWSzJIV5eHKnc4Ppc44> NIDxfHczPDN5NkW4Oi=>
SUM-159 MnjNSpVv[3Srb36gRZN{[Xl? NInCWWYyOCEEtV2= NVvxdoIyOjRiaB?= M{DJbmROW00EoB?= MV\y[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= NVvibGZlOjR|N{[1PFY>
SK-BR-3 M37zWGZ2dmO2aX;uJGF{e2G7 MkniNVAhyrWP MWiyOEBp NGD2UHdFVVORwrC= MWry[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= Ml\vNlQ{PzZ3OE[=
MCF7-HER2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXKwMVExKM7:TR?= MYC0PEBp NHq1dWxFVVOR NYP2NVJ5cW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> M{HMPFI1Ojl5NUC4
MCF7-HER2 M{X4T2Z2dmO2aX;uJGF{e2G7 M2jsT|Uh|ryP MWGyOEBp NXr5NnBVTE2VTx?= NFfYR5llcW2rbnnzbIV{KFOxeD2yMEBQ[3RvNDygZY5lKHOudXeg[ZhxemW|c3nvci=> M2\KRlI1Ojl5NUC4
MCF7-HER2 M4jQ[mZ2dmO2aX;uJGF{e2G7 M4PGNlUh|ryP MWqyOEBp NEHBOY5FVVOR NIrpWYFl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wy|IH;mJGVOXCCvYYLr[ZJ{NCC4aX3lcpRqdiCjbnSgd4x2\w>? MnrPNlQzQTd3MEi=
MCF7-HER2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv6OUDPxE1? MnnXNlQhcA>? M3jUZmROW09? NHvjVoVmdmijbnPld{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHPvcYJqdmWmIIfpeIghUGW{Y3XweIlv NGT5cZgzPDJ7N{WwPC=>
HMECs  M4\MUWZ2dmO2aX;uJGF{e2G7 MkTPNVAh|ryP M1LpTVIhcA>? MWDpcohq[mm2czDJSm7PucLibXXkbYF1\WRicHjvd5Bpd3K7bHH0bY9vKG:oIGPURXQyNCCVVFHUNkBidmRiU2TBWFM> MYKyOFIyOTN{Nx?=
HTR8/SVneo MXnGeY5kfGmxbjDBd5NigQ>? NWruSoI1OcLizszNxsA> NVnIUoZMOcLiaB?= M33zbpN2eHC{ZYPz[YQhV1OPLXnu[JVk\WRiU2TBWFMheGixc4Doc5J6dGG2aX;u NFTkUZEzPDB4MEK0NS=>
HTR8/SVneo M3HFZWZ2dmO2aX;uJGF{e2G7 Mn3wNE42NzIEoN88UeKh NHPaeZM1QCCq MoLSdoV{fG:{ZYOgeIhmKGW6cILld5Nqd25ib3[gSU1k[WSqZYLpckB{fXCycnXzd4VlKGK7IF;TUS=> MknkNlQxPjB{NEG=
HTR8/SVneo M3ToOGZ2dmO2aX;uJGF{e2G7 Ml7PNeKh|ryPwrC= Mnz5OFghcA>? MUXzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyCvaXfyZZRqd25iYomgU3NOyqB? MnPMNlQxPjB{NEG=
C13* MlzLRZBweHSxc3nzJGF{e2G7 NW\KVlloOC1zMDFOwG0> M1XCTFI1NzR6IHi= MoXEbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= MXiyN|k3OjV3OB?=
OV2008 M3z0OmFxd3C2b4Ppd{BCe3OjeR?= NHizVJcxNTFyIN88US=> MlnMNlQwPDhiaB?= MYrpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3WgZY5lKHSrbXWg[IVx\W6mZX70JI1idm6nch?= MlezNlM6PjJ3NUi=
C13* MV3BdI9xfG:|aYOgRZN{[Xl? M4LPR|I1NzR6IHi= MV;lcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= NVHIdHJsOjN7NkK1OVg>
OV2008 M1nIeWFxd3C2b4Ppd{BCe3OjeR?= NFG5eXEzPC92ODDo NFi5eHhmdmijbnPld{BkcXOybHH0bY4ucW6mdXPl[EBieG:ydH;zbZM> MUmyN|k3OjV3OB?=
W480  NHzRS5VHfW6ldHnvckBCe3OjeR?= Mn;lNk42NzFyIN88US=> MX[zNEBucW5? MXHEUXNQ NWjoUGwxe2Wwc3n0bZpmeyClZXzsd{B1dyClaHXtc5Ji\GmxdHjldoFxgSCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? M1\XTVI{QTN2OUey
SW837 NE\INpVHfW6ldHnvckBCe3OjeR?= MYCyMlUwOTBizszN MlPWN|AhdWmw MUPEUXNQ NYjDfVBte2Wwc3n0bZpmeyClZXzsd{B1dyClaHXtc5Ji\GmxdHjldoFxgSCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NV65O3M3OjN7M{S5O|I>
T24 NVjBXmJxTnWwY4Tpc44hSXO|YYm= NGnzU4ozNzFyL{KwJO69VQ>? MkG4NlQhcA>? Mlj1Z4F2e2W|IHTvd4Uu\GWyZX7k[Y51KGmwaHnibZRqd25ib3[geIhmKEO[Q1yxNk1qdmS3Y3XkJIlv[3KnYYPlJI9nKGmwdnHkbY5oKGOnbHzz M37RRVI{PTJ4MEe5
CNE1 NF;SdlFHfW6ldHnvckBCe3OjeR?= MlSzNlAhyrWP M325bFQ5KGh? MUXicI9kc3NidHjlJGlNNTZiaX7jdoVie2WmIIDoc5NxcG:{eXzheIlwdiCxZjDTeIF1Ow>? MWWyN|M5OjlzNB?=
CNE2 M33wOmZ2dmO2aX;uJGF{e2G7 M{D6ZVIxKML3TR?= MoXROFghcA>? M1HRVYJtd2OtczD0bIUhUUxvNjDpcoNz\WG|ZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJHN1[XR| NGjtV3YzOzN6MkmxOC=>
HONE1 MlvPSpVv[3Srb36gRZN{[Xl? MlPPNlAhyrWP MkTKOFghcA>? NGjaWmxjdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= NVvtdJg{OjN|OEK5NVQ>
CNE1 M2nkUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPYVoI1KM7:TR?= NUCxTlNSe2mpbnnmbYNidnSueTDy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 MkXzNlM{QDJ7MUS=
CNE1 NHTKZ|hHfW6ldHnvckBCe3OjeR?= NFm4bpQxNTJyIN88US=> NFrUO3MxNTRiaB?= M2\wbIlvcGmkaYTzJHN1[XR|IHHjeIl3[XSrb36gbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy M4rYUVI{Ozh{OUG0
CNE2 M{nPTmZ2dmO2aX;uJGF{e2G7 NG\jPIcxNTJyIN88US=> NFzFWFMxNTRiaB?= MWrpcohq[mm2czDTeIF1OyCjY4TpeoF1cW:wIHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= MlvRNlM{QDJ7MUS=
HONE1 NF\t[25HfW6ldHnvckBCe3OjeR?= MXewMVIxKM7:TR?= NYfBW3pnOC12IHi= M4KwNolvcGmkaYTzJHN1[XR|IHHjeIl3[XSrb36gbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy MY[yN|M5OjlzNB?=
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RAW264.7 MWnGeY5kfGmxbjDBd5NigQ>? M2LKUlExKM7:TR?= M2TNUVEzKGh? M2\peYFjem:pYYTld{B1cGVibWLORUBmgHC{ZYPzbY9veyCxZjDKRWszNCCVVFHUNUwhW1SDVEKsJIFv\CCVVFHUN{BqdmS3Y3XkJIJ6KESRTjDhcoQhXC1{IITvfIlv M1ry[|IzPDV2NEOx
RAW264.7 NHjpflZCeG:ydH;zbZMhSXO|YYm= NYPLN5dGPS9zMDFOwG0> Ml;iOFUhdWmw MoDk[Y5p[W6lZYOgeI95cW6|IHnu[JVk\WRiYYDvdJRwe2m|IHHu[EBOVVBibH;zdy=> NVLGbWRMOjJ2NUS0N|E>
SW480 MlXDR4VtdCCYaXHibYxqfHliQYPzZZk> M3HaZVUwOTBxMkCg{txO NVTF[oFDPzJiaB?= MkHQbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? NFntOmMzOTlyMEO5Oy=>
HCT116 M2fDdGNmdGxiVnnhZoltcXS7IFHzd4F6 NF33O3o2NzFyL{KwJO69VQ>? MV23NkBp Mme2bY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? MW[yNVkxODN7Nx?=
DLD-1  MV3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NW\aVmh2PS9zMD:yNEDPxE1? MYi3NkBp MVjpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCxZjD0bIUhSUyGSDuvR2QyOzNtwrDj[Yxtew>? NHX2fIIzOTlyMEO5Oy=>
SNU387  MYDD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MlnCNlDDqM7:TdMg MnXoNlQhcA>? MXPy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 MW[yNVMyOTl5NR?=
SNU398 MkTBR4VtdCCYaXHibYxqfHliQYPzZZk> M13zUVIxyqEQvF5CpC=> NUDhb2ZyOjRiaB?= NWjpdYlCemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= NEHLSWgzOTNzMUm3OS=>
HepG2 M{[yVGNmdGxiVnnhZoltcXS7IFHzd4F6 NELlVpYzOMLizszNxsA> NITsZYszPCCq NYThN5EzemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= M1PJR|IyOzFzOUe1
Huh-7 MW\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M3XwPFIxyqEQvF5CpC=> MXSyOEBp NVfw[nFDemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= NIXTXIszOTNzMUm3OS=>
VSMC M4rsNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H3WlMwPS9zMDFOwG0> NHG4T4E{OCCvaX6= NYDUW3puTE2VTx?= M1HtUpBz\X[nboTzJHBFT0ZvIHHu[EB1cHKxbXLpck1u\WSrYYTl[EBXW02FIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NXH5cXFWOjB6NEezNFY>
MDA-MB-231 Mon6RZBweHSxc3nzJGF{e2G7 MYixNEDPxE1? MlzkNlQhcA>? M3LxNGROW00EoB?= MmPjbY5lfWOnczDhdI9xfG:|aYO= MoLXNVcyOTRyMEW=
MDA-MB-435S MXPBdI9xfG:|aYOgRZN{[Xl? NIPpb|MyOCEQvF2= NYj5TXozOjRiaB?= MYjEUXNQyqB? NFrqVHVqdmS3Y3XzJIFxd3C2b4Ppdy=> MUOxO|EyPDByNR?=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+H2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID