Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017. Stattic purchased from Selleck.

    LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

  • (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 NHjSdnhHfW6ldHnvckBCe3OjeR?= NHzFR44yOOLCid88US=> NFG2b5Q16oDLaB?= NWL0U|NUemW4ZYLz[ZMhfGinIHXm[oVkfHNib3[gTWwuOjd? NYXndIN3OjZ|M{m2N|M>
NPC  MYrGeY5kfGmxbjDBd5NigQ>? NEPX[ncxNTdwNTFCuW0> MVrhZo9tcXOqZYOgSW1VNWyra3WgcY9t\WO3bHHyJIFtfGW{YYTpc45{NCCjbnSgZ4VtdCCvaXfyZZRqd25iYX7kJIlvfmG|aX;uJIlv\HWlZXSgZpkhWkuLUDDrco9kc2Sxd36= NI[ybYkzPTlzNUSzNC=>
HASMC NVrFPYJuTnWwY4Tpc44hSXO|YYm= NVHPSY91OS5{NT21JO69VQ>? MXqyNEBucW5? NI\kPHdFVVORwrC= NYHGeZl2cW6qaXLpeJMheC1qWTmtV3RCXC1zLEOsOUB{cWewYXzzxsA> MoT5NlU5PDl4MkK=
H9c2  NYXIfpVmTnWwY4Tpc44hSXO|YYm= M3TxS|IwOTBizszN MmHCNkBp MXPEUXNQyqB? MWHhZpJw\2G2ZYRCpJRp\SCleYTvdJJwfGWldHn2[UBm\m[nY4TzJI9nKEmOLUK3JIFo[Wmwc4SgV2g> NX7XdIFvOjV6MkC5NFc>
A431 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnFNuKh|ryP MX:yxsBp NWf0R3A1[myxY3vzJGVITi2{ZY\ldpNm\CCmZXPy[YF{\XNiaX6gZ4VtdCC4aXHibYxqfHl? MXqyOVczODR|NR?=
A431 M2flfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVeyxsDPxE1? M3\aelLDqGh? Mn;abY5kemWjc3XzJIlvKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIPobYtwdmmw Moj1NlU4OjB2M{W=
SiHa MUfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2j1[|UuPzVibl2= NI\6SIUzPMLiaNMg M1\BZ5Npd3e|IH3vdpBpd2yxZ4mgc4Yh[SC2eYDpZ4FtKGGyb4D0c5Rq[yClZXzsJIFv\CCmb4PlMYRmeGWwZHXueEBtd3O|IH;mJINmdGxidnnhZoltcXS7wrC= MUiyOVU{QTZ2NB?=
SiHa MYPGeY5kfGmxbjDBd5NigQ>? M3zaZlUuPzVibl2= MYiyOOKhcMLi M{nKS5Jm\HWlZYOgeIhmyqCyaH;zdIhwenmuYYTpc44h[XRidHjlJJR6em:|aX7lJJJme2mmdXWgO|A2yqB? M334d|I2PTN7NkS0
ECA109 M4\SXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DUOFAuOjBizszN Mln6NlTDqGkEoB?= M13qR2lEPTB;NT61NEDPxE1? MVGyOVQ6OjR6MB?=
TE13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLyZoJ6OC1{MDFOwG0> NWLXfIhjOjUEoHlCpC=> MmLFTWM2OD14LkG1xsDPxE1? Mn;PNlU1QTJ2OEC=
KYSE150  M33FUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3KOopxOC1{MDFOwG0> MWWyOOKhcMLi MVLJR|UxRTF{Lk[0xsDPxE1? M3\XZ|I2PDl{NEiw
ECA109 NGjDVnpEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 MUGwMlXDqM7:TR?= MoXNNlTDqGkEoB?= MnOzd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= NW\tdlQyOjV2OUK0PFA>
TE13 M{LiWGNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= MXGwMlXDqM7:TR?= NXfBPFBvOjUEoHlCpC=> M4PrN5N2eHC{ZYPz[ZMhfGinIHPsc45w\2WwaXOg[o9zdWG2aX;u M4fpNlI2PDl{NEiw
KYSE150  NUH5Wlc1S2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> NWrCV3VIOC53wrFOwG0> NF7Sd4MzPMLiaNMg MlvSd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= MV2yOVQ6OjR6MB?=
ECA109 M1fIVmZ2dmO2aX;uJGF{e2G7 NHG1e4sxNjYEoN88US=> M2nXPVI1yqCqwrC= MYjlcohidmOnczDJVk1qdmS3Y3XkJIdmdmW{YYTpc44hd2ZiRGPCdy=> MlrRNlU1QTJ2OEC=
PC3M-1E8 MlnsSpVv[3Srb36gRZN{[Xl? NYrsSYd3Oi53L{WvNVAh|ryP NGHCcngxNTRiaB?= NF:2fpJqdmirYnn0d{B1cGViU2TBWFMh[WO2aY\heIlwdiCrbjDhJIRwe2VvIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XMEoB?= NInBcXMzPTJ4MUO2OS=>
PC3M-1E8 M2C2O2Z2dmO2aX;uJGF{e2G7 NVn6bIFFOTBizszN NV[zfodQOjRiaB?= MYnkc5dvemWpdXzheIV{KEKlbD34UEwhe3W{dnn2bY4h[W6mIHOtUZlk MoOwNlUzPjF|NkW=
PC3M-1E8 MkXUSpVv[3Srb36gRZN{[Xl? M{DWTFExKM7:TR?= MljGNlQhcA>? NXLhdlYxcW6qaXLpeJMhUUxvNjDpcoR2[2WmIGPURXQ{KGGldHn2ZZRqd25iYX7kJJRp\SCLTD22MYlv\HWlZXSgV3RCXDNiYXP0bZZifGmxbh?= Ml3HNlUzPjF|NkW=
PC3M-1E8 MXTDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 MmDoNk42NzVxMUCg{txO NYfxSlhtcW6qaXLpeJPDqHSqZTDjc4xwdnliZn;ycYF1cW:wIIPp[45q\mmlYX70cJk> MlXnNlUzPjF|NkW=
MDA-MB-231 NIPqWYFHfW6ldHnvckBCe3OjeR?= M4PVcVIxKM7:TR?= MkDKNkBp M{LPXoV5cGmkaYTzJHNv[WmuIHHu[EBGNWOjZHjldolvKGW6cILld5Nqd25? M1HtU|I2OTV|M{S5
H9c2 MVTGeY5kfGmxbjDBd5NigQ>? M2nDW|IxKML3TR?= MnLLN|AhdWmw NH22UVFFVVORwrC= MYHhZo9tcXOqZYOgdJJweG:ob3ytbY5lfWOnZDDBT3QheGixc4Doc5J6dGG2aX;uJIF1KGKxdHigd4VzPDd|IHHu[EB1cHJ|MEi= M1S2elI2OTB3ME[3
HaCaT  MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TTXlExKML3TR?= Mly1NlAhdWmw MkGzSG1UV8Li NWD2e3RX\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= MVKyOVAyOzlyNx?=
Caki-1 MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYqxNEDDvU1? M3r3fVIxKG2rbh?= NEXpRo9FVVORwrC= NXq1N5F2\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= M2XSXFI2ODF|OUC3
HaCaT  MVHBdI9xfG:|aYOgRZN{[Xl? MljCNVAhyrWP MUSyNEBucW5? MUfEUXNQyqB? NIDNSpdqdmO{ZXHz[ZMheHKxcH;yeIlwdnNib3[gZZBweHSxdHnjJINmdGy|IHT1[UB1dyC2cnXheI1mdnRid3n0bEB{d3KjZnXubYIhd3Jic4XubZRqdmmk M{LOXVI2ODF|OUC3
FHL-primed hNSCs NYnjcHhyS2WubDDWbYFjcWyrdImgRZN{[Xl? NES1NJoxNjB{LUWg{txO NWLTfGExPzJiaB?= MU\s[YFleyC2bzD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDheEBpcWeqIHPvcoNmdnS{YYTpc44> M3naNFI1QTR3NEO0
ELL-primed hNSCs M{fiWWNmdGxiVnnhZoltcXS7IFHzd4F6 M33vflAvODJvNTFOwG0> NHfKUW84OiCq NX3le5FYdGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w NIjrdJUzPDl2NUSzOC=>
SS MU\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NY[zVXF6OS1zMDFOwG0> Mo\hO|IhcA>? NV7T[JR5TE2VTx?= M1nqOoNifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg MVeyOFc2PjFzMR?=
SeAx  NUn2NIp4S2WubDDWbYFjcWyrdImgRZN{[Xl? MV6xMVExKM7:TR?= M135flczKGh? NX;lTYJSTE2VTx?= M1XiU4NifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg M1S1PVI1PzV4MUGx
HuT-78 M17vcWNmdGxiVnnhZoltcXS7IFHzd4F6 MVSxMVExKM7:TR?= MXi3NkBp M1HaS2ROW09? M4XJT4NifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg MVmyOFc2PjFzMR?=
CD4+ MVfBdI9xfG:|aYOgRZN{[Xl? MUGxNQKBkc7:bR?= NUPYXGJQOjRiaB?= MXPEUXNQ M1zPZ4lv\HWlZYOgZZBweHSxc3nzJJN1em:wZ3z5 Mlu2NlQ4PTZzMUG=
MCF-7 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TRNFAvPDZ7LUOuO|Uh|ryP M2PQNVUh\A>? NGnO[FNz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= M3fPNlI1PzJ6MEe4
MCF-7/LCC1 NVLSOGtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXxZWVlOC52NkmtN{44PSEQvF2= MoSwOUBl MX\y[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? MYSyOFczQDB5OB?=
MCF-7/LCC9 M2XxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVSwMlQ3QS1|Lke1JO69VQ>? M3e4d|Uh\A>? MV7y[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? M2XIe|I1PzJ6MEe4
HaCaT MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LOZ|ExKML3TR?= NXT3fGhDOjBibXnu Mly5SG1UV8Li MXPlcohidmOnczDleoVzd2yrbYXzMYlv\HWlZXSgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdg>? M{jCPVI1PDJ|MUOx
HaCaT NELiWlZCeG:ydH;zbZMhSXO|YYm= MlTyNVAhyrWP NITNUFYzOCCvaX6= M{jmS2ROW00EoB?= NVjadYFn\W6qYX7j[ZMhfGinIHHwc5B1d3SrYzDl[oZm[3S|IH;mJIV3\XKxbHnteZM> MUCyOFQzOzF|MR?=
MDA-MB-231 NH;oSWdHfW6ldHnvckBCe3OjeR?= NFvEZlMyOCEEtV2= MnjxNlQhcA>? Mlj5SG1UV8Li MUny[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= NYLE[JJjOjR|N{[1PFY>
SUM-159 NYX6UnBtTnWwY4Tpc44hSXO|YYm= NEfTNFkyOCEEtV2= Ml\rNlQhcA>? NVLKOFdtTE2VT9Mg NG\lfGpz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> NFqzeXEzPDN5NkW4Oi=>
SK-BR-3 NFzKUWlHfW6ldHnvckBCe3OjeR?= NH63NWsyOCEEtV2= MkPwNlQhcA>? NHn5[2VFVVORwrC= NV7jdpVEemWmdXPld{BRNVOWQWSzJIV5eHKnc4Ppc44> M3HiTlI1Ozd4NUi2
MCF7-HER2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDFNE0yOCEQvF2= MWi0PEBp MVLEUXNQ MnXsbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MUWyOFI6PzVyOB?=
MCF7-HER2 NVHqN5dVTnWwY4Tpc44hSXO|YYm= MXm1JO69VQ>? NWWwcoQ6OjRiaB?= MWXEUXNQ Mmrp[IlucW6rc3jld{BUd3hvMjygU4N1NTRuIHHu[EB{dHWpIHX4dJJme3Orb36= NV25RnhTOjR{OUe1NFg>
MCF7-HER2 NGjXUFRHfW6ldHnvckBCe3OjeR?= MWS1JO69VQ>? MVGyOEBp NHzaUIRFVVOR NHjzZ3Fl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wy|IH;mJGVOXCCvYYLr[ZJ{NCC4aX3lcpRqdiCjbnSgd4x2\w>? NWjaU3U1OjR{OUe1NFg>
MCF7-HER2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXU[FBrPSEQvF2= M1vPZVI1KGh? M1\EOWROW09? M{ftV4VvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iY3;tZolv\WRid3n0bEBJ\XKlZYD0bY4> NFLOVnEzPDJ7N{WwPC=>
HMECs  M13Yc2Z2dmO2aX;uJGF{e2G7 M1rPZVExKM7:TR?= NITOWGkzKGh? MUfpcohq[mm2czDJSm7PucLibXXkbYF1\WRicHjvd5Bpd3K7bHH0bY9vKG:oIGPURXQyNCCVVFHUNkBidmRiU2TBWFM> MonwNlQzOTF|Mke=
HTR8/SVneo NGLrXlBHfW6ldHnvckBCe3OjeR?= MWCxxsDPxE4EoB?= M1;PeVHDqGh? MmLXd5VxeHKnc4Pl[EBQW01vaX7keYNm\CCVVFHUN{BxcG:|cHjvdplt[XSrb36= NUmwXHNlOjRyNkCyOFE>
HTR8/SVneo MV7GeY5kfGmxbjDBd5NigQ>? NGKxXFYxNjVxMdMg{txOyqB? MUO0PEBp NFy4c4Rz\XO2b4Lld{B1cGViZYjwdoV{e2mxbjDv[kBGNWOjZHjldolvKHO3cIDy[ZN{\WRiYomgU3NO MXyyOFA3ODJ2MR?=
HTR8/SVneo NUToUlRrTnWwY4Tpc44hSXO|YYm= MWGxxsDPxE4EoB?= MX:0PEBp M4DqWpNq\26rZnnjZY51dHliaX7jdoVie2W|IH3p[5JifGmxbjDifUBQW04EoB?= NVXCdG5EOjRyNkCyOFE>
C13* MmPLRZBweHSxc3nzJGF{e2G7 NVr5[mg6OC1zMDFOwG0> MV2yOE81QCCq MoTRbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= MVOyN|k3OjV3OB?=
OV2008 NYHnbVZ4SXCxcITvd4l{KEG|c3H5 NEjHPWsxNTFyIN88US=> MnfHNlQwPDhiaB?= M2Dvcolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy M4\4eFI{QTZ{NUW4
C13* NIj6XWNCeG:ydH;zbZMhSXO|YYm= NVzaU5MyOjRxNEigbC=> MV3lcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= NUD6eItyOjN7NkK1OVg>
OV2008 NILZcYlCeG:ydH;zbZMhSXO|YYm= M4Lr[VI1NzR6IHi= MVTlcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= NHzqelMzOzl4MkW1PC=>
W480  NHjJd|NHfW6ldHnvckBCe3OjeR?= NEW1OXYzNjVxMUCg{txO NGi1WI4{OCCvaX6= NFLDU49FVVOR Mk\Id4Vve2m2aYrld{Bk\WyuczD0c{BkcGWvb4Lh[IlwfGincnHwfUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MXuyN|k{PDl5Mh?=
SW837 M{XQUmZ2dmO2aX;uJGF{e2G7 M3XwN|IvPS9zMDFOwG0> MWmzNEBucW5? Mom2SG1UVw>? NV7hbnZle2Wwc3n0bZpmeyClZXzsd{B1dyClaHXtc5Ji\GmxdHjldoFxgSCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MViyN|k{PDl5Mh?=
T24 NVjWUVBUTnWwY4Tpc44hSXO|YYm= NGXhVVkzNzFyL{KwJO69VQ>? M4ezdlI1KGh? NH\6OoVk[XW|ZYOg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGViQ2jDUFEzNWmwZIXj[YQhcW6lcnXhd4Uhd2ZiaX72ZYRqdmdiY3XscJM> M1vjWVI{PTJ4MEe5
CNE1 MYnGeY5kfGmxbjDBd5NigQ>? MX2yNEDDvU1? MXS0PEBp M2XnToJtd2OtczD0bIUhUUxvNjDpcoNz\WG|ZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJHN1[XR| NY\YWItsOjN|OEK5NVQ>
CNE2 NVXEOmhYTnWwY4Tpc44hSXO|YYm= NIjYc3gzOCEEtV2= M{LWe|Q5KGh? NHuzZ5RjdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= MlLHNlM{QDJ7MUS=
HONE1 MXTGeY5kfGmxbjDBd5NigQ>? M2i0c|IxKML3TR?= MYC0PEBp Mor1Zoxw[2u|IITo[UBKVC14IHnuZ5Jm[XOnZDDwbI9{eGixconsZZRqd25ib3[gV5RifDN? NVTYUVhnOjN|OEK5NVQ>
CNE1 MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7iO4o1KM7:TR?= NW\reGRme2mpbnnmbYNidnSueTDy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 NXfPcVBKOjN|OEK5NVQ>
CNE1 NFfGOVlHfW6ldHnvckBCe3OjeR?= MmPHNE0zOCEQvF2= NV3zeo96OC12IHi= MorBbY5pcWKrdIOgV5RifDNiYXP0bZZifGmxbjDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NIHtbpozOzN6MkmxOC=>
CNE2 M37mNWZ2dmO2aX;uJGF{e2G7 MXywMVIxKM7:TR?= NUXWVFdXOC12IHi= Mn7wbY5pcWKrdIOgV5RifDNiYXP0bZZifGmxbjDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= MWeyN|M5OjlzNB?=
HONE1 Mk\PSpVv[3Srb36gRZN{[Xl? Ml7LNE0zOCEQvF2= MlH2NE01KGh? NGnwV2JqdmirYnn0d{BUfGG2MzDhZ5RqfmG2aX;uJIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> M4\SclI{Ozh{OUG0
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CNE2 NFTzXVJE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NXfaV|NDOC53LU[0JO69VQ>? NYPicmtOPDhiaB?= MorSd5VxeHKnc4Pld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NIjpfXczOzN6MkmxOC=>
HONE1 Mm\OR4VtdCCYaXHibYxqfHliQYPzZZk> MmO4NE42NTZ2IN88US=> NV3P[mFtPDhiaB?= MWHzeZBxemW|c3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NEOzR4czOzN6MkmxOC=>
C666-1  NHnjUJRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M2juOVAvPS14NDFOwG0> MWO0PEBp NFnsdHB{fXCycnXzd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> MkfENlM{QDJ7MUS=
CNE1 NH35ZVhCeG:ydH;zbZMhSXO|YYm= M4T6eVExKML3TdMg NGLnRpk1QCCq NH7PSYpqdmS3Y3XzJIFxd3C2b4Ppd:Kh MUWyN|M5OjlzNB?=
CNE2 M4n1XGFxd3C2b4Ppd{BCe3OjeR?= MkLsNVAhyrWPwrC= NVfYWIRmPDhiaB?= M{Tyc4lv\HWlZYOgZZBweHSxc3nzxsA> M3PGdVI{Ozh{OUG0
HONE1 MnzmRZBweHSxc3nzJGF{e2G7 M2fofVExKML3TdMg M4DYc|Q5KGh? NE\IZ5lqdmS3Y3XzJIFxd3C2b4Ppd:Kh NG[1bYEzOzN6MkmxOC=>
CNE2 NV3aPIpCS2WubDDWbYFjcWyrdImgRZN{[Xl? MVyxM|Ih|ryP NF7OflI1QCCq MkK4d4Vve2m2aYrlJINmdGy|IITvJJJi\GmxdHjldoFxgQ>? MVGyN|M5OjlzNB?=
HONE1 NGX4V3NE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NVfrW2FZOS9{IN88US=> MnzHOFghcA>? NFexWZp{\W6|aYTpfoUh[2WubIOgeI8hemGmaX;0bIVz[XC7 M2DqZVI{Ozh{OUG0
C666-1  NISweGZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MYCxM|Ih|ryP MXG0PEBp NHXrcGh{\W6|aYTpfoUh[2WubIOgeI8hemGmaX;0bIVz[XC7 MYqyN|M5OjlzNB?=
HEC-1A MY\GeY5kfGmxbjDBd5NigQ>? M2\PVlHDqM7:TdMg MXWyOEBp MV7EUXNQ M{[2NoJtd2OtczD0bIUhVVWFMkCt[Y5p[W6lZXSgbY53[XOrb36geJJq\2encnXkJIJ6KDFyJTDGRnM> NWHpPXJ3OjN{NkKyNFg>
RL95-2 NInrWZNHfW6ldHnvckBCe3OjeR?= M2m0VVHDqM7:TdMg NE\QT2kzPCCq M1TtOmROW09? MXHicI9kc3NidHjlJG1WSzJyLXXubIFv[2WmIHnueoF{cW:wIITybYdo\XKnZDDifUAyOCViRlLT MUiyN|I3OjJyOB?=
HEC-1A M2\kVWZ2dmO2aX;uJGF{e2G7 M325W|HDqM7:TdMg MYiyOEBp MYXEUXNQ NVzVXWdQ[myxY3vzJJRp\SCPVVOyNE1mdmijbnPl[EBqdn[jc3nvckB1emmpZ3Xy[YQh[nliRVfGxsA> NYm2cJZJOjN{NkKyNFg>
RL95-2 NFrrWHZHfW6ldHnvckBCe3OjeR?= NFTJR5QyyqEQvF5CpC=> MVOyOEBp MWHEUXNQ MVXicI9kc3NidHjlJG1WSzJyLXXubIFv[2WmIHnueoF{cW:wIITybYdo\XKnZDDifUBGT0cEoB?= MWiyN|I3OjJyOB?=
CT26 NIPMTIVHfW6ldHnvckBCe3OjeR?= NWDyZo9OOjBibV2= NXnFXGN7OSCq MUDzeZBxemW|c3XzJGhITi2rbnT1Z4VlKF[HR1[g[ZhxemW|c3nvcuKh MUSyN|I{OzF4Mx?=
UM-SCC-17B M2HF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGizbnZKSzVyPUKuOVYzKMLzIECuOFA6KM7:TTygS2k2OD1zLkK3PUDDuSByLkG5OEDPxE1? M{\Y[VIzPzdyOEm5
OSC-19 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HGWmlEPTB;Mz60PFEhyrFiMD65OVMh|ryPLDDHTVUxRTFwM{[2JOKyKDBwN{ewJO69VQ>? MlrNNlI4PzB6OUm=
Cal33 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrrelhKSzVyPUKuNlgzKMLzIECuOFI{KM7:TTygS2k2OD1zLkO0PUDDuSByLkO2N{DPxE1? MV6yNlc4ODh7OR?=
UM-SCC-22B M3Pz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHXcnJKSzVyPUKuOlQ5KMLzIECuOVQzKM7:TTygS2k2OD1zLkOyNEDDuSByLkKwOEDPxE1? NXrjSoo1OjJ5N{C4PVk>
UM-SCC-17B NULJR2ZRTnWwY4Tpc44hSXO|YYm= MoTDNE0{OCEQvF2= NXjtdGR5OC1{NDDo M1\nNIlvcGmkaYTzJHNVSVR|IHHjeIl3[XSrb36g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= NFqxbXIzOjd5MEi5PS=>
OSC-19 NF\BNWZHfW6ldHnvckBCe3OjeR?= Mof3NE0{OCEQvF2= NHH6[ooxNTJ2IHi= Ml6ybY5pcWKrdIOgV3RCXDNiYXP0bZZifGmxbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfGy7 MoG3NlI4PzB6OUm=
Cal33 NV;jOlJlTnWwY4Tpc44hSXO|YYm= NE[5c|UxNTNyIN88US=> MnzzNE0zPCCq M4HG[olvcGmkaYTzJHNVSVR|IHHjeIl3[XSrb36g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= M{m2e|IzPzdyOEm5
UM-SCC-22B NEfXNnBHfW6ldHnvckBCe3OjeR?= MX[wMVMxKM7:TR?= M{C0PFAuOjRiaB?= NXnxR3N2cW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 MUOyNlc4ODh7OR?=
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U-373MG NELYc2NE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MX6wMVExKM7:TR?= M3zLe|czKGh? M4HWOGROW09? NXrFOW12cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= M1jKeVI2PDN4Nkiy
SH-SY5Y MVLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGTmWmQxNTFyIN88US=> MV63NkBp MnnXSG1UVw>? M{\kb4lvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NFGzSZozPTR|Nk[4Ni=>
Tu-9648 MlzQR4VtdCCYaXHibYxqfHliQYPzZZk> MX[wMVExKM7:TR?= NIDPfZo4OiCq MnrYSG1UVw>? MWjpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MU[yOVQ{PjZ6Mh?=
Neuro-2a MoDpR4VtdCCYaXHibYxqfHliQYPzZZk> NVjXOJJQOC1zMDFOwG0> MoHvO|IhcA>? NHTEdndFVVOR NX;sUGY5cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= M{f6WVI2PDN4Nkiy
PCNs NYHjdHVjS2WubDDWbYFjcWyrdImgRZN{[Xl? MUWwMVExKM7:TR?= NXLxVVd{PzJiaB?= Ml7xSG1UVw>? MYPpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MYeyOVQ{PjZ6Mh?=
PGCs MlvYR4VtdCCYaXHibYxqfHliQYPzZZk> MU[wMVExKM7:TR?= M3\FfVczKGh? MVXEUXNQ NEPo[I1qdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 M2rVXVI2PDN4Nkiy
RAW264.7 MnjjSpVv[3Srb36gRZN{[Xl? M4S2eVExKM7:TR?= MkTNNVIhcA>? MkfWZYJzd2ejdHXzJJRp\SCvUl7BJIV5eHKnc4Ppc45{KG:oIFrBT|ItKFOWQWSxMEBUXEGWMjygZY5lKFOWQWSzJIlv\HWlZXSgZpkhTE:QIHHu[EBVNTJidH;4bY4> M{\4Z|IzPDV2NEOx
RAW264.7 M3XQZ2Fxd3C2b4Ppd{BCe3OjeR?= M3jse|UwOTBizszN NIfuVFU1PSCvaX6= NV:3VGpm\W6qYX7j[ZMhfG:6aX7zJIlv\HWlZXSgZZBweHSxc3nzJIFv\CCPTWCgcI9{ew>? NVK5eItuOjJ2NUS0N|E>
SW480 NWXK[2NMS2WubDDWbYFjcWyrdImgRZN{[Xl? MYe1M|ExNzJyIN88US=> MXS3NkBp M{DtOYlvcGmkaYTzJINmdGxidnnhZoltcXS7IH;mJJRp\SCDTFTIL{9ETDF|MzxCpINmdGy| NVnsVW5LOjF7MECzPVc>
HCT116 M3W2Z2NmdGxiVnnhZoltcXS7IFHzd4F6 NXjrdJdMPS9zMD:yNEDPxE1? M2DzcFczKGh? NFrJPYVqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDv[kB1cGViQVzETEswS0RzM{OrxsBk\Wyucx?= NV34Um1GOjF7MECzPVc>
DLD-1  NGLsVFNE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MoP5OU8yOC9{MDFOwG0> MoXvO|IhcA>? NULqNJpYcW6qaXLpeJMh[2WubDD2bYFjcWyrdImgc4YhfGinIFHMSGgsN0OGMUOzL:Kh[2WubIO= NWXwUHhCOjF7MECzPVc>
SNU387  MWHD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NXq3SGJzOjEEoN88UeKh M4HWUFI1KGh? M3L0OZJm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MVqyNVMyOTl5NR?=
SNU398 MlvwR4VtdCCYaXHibYxqfHliQYPzZZk> M3[0RVIxyqEQvF5CpC=> NVv3VXZXOjRiaB?= M37PWpJm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MUGyNVMyOTl5NR?=
HepG2 M2HS[WNmdGxiVnnhZoltcXS7IFHzd4F6 MoC4NlDDqM7:TdMg M2nrPVI1KGh? MVvy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 M3vu[VIyOzFzOUe1
Huh-7 MmHrR4VtdCCYaXHibYxqfHliQYPzZZk> MlXMNlDDqM7:TdMg M{TrWVI1KGh? MYfy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 MVOyNVMyOTl5NR?=
VSMC NUS4VnhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf0N{82NzFyIN88US=> NFvCS2k{OCCvaX6= NGruXXpFVVOR NVW3NIcyeHKndnXueJMhWESJRj2gZY5lKHSqcn;tZolvNW2nZHnheIVlKF[VTVOgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NFHqW3UzODh2N{OwOi=>
MDA-MB-231 NV[ycVRJSXCxcITvd4l{KEG|c3H5 MlHpNVAh|ryP MXWyOEBp MlvVSG1UV8Li M{f6[Ilv\HWlZYOgZZBweHSxc3nz MV[xO|EyPDByNR?=
MDA-MB-435S Mn7FRZBweHSxc3nzJGF{e2G7 M{PmV|ExKM7:TR?= MUiyOEBp NHrKNWNFVVORwrC= M1XMbIlv\HWlZYOgZZBweHSxc3nz M{DUN|E4OTF2MEC1

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+H2O
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

Related Antibodies

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID