Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017, 7:41404. Stattic purchased from Selleck.

    LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

  • (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MXTGeY5kfGmxbjDBd5NigQ>? NV71S5JCOTEkgJpOwG0> NIjzcVk16oDLaB?= MXTy[ZZmenOnczD0bIUh\W[oZXP0d{Bw\iCLTD2yOy=> M1npTVI3OzN7NkOz
NPC  M3nNeGZ2dmO2aX;uJGF{e2G7 MWmwMVcvPSEEtV2= MYjhZo9tcXOqZYOgSW1VNWyra3WgcY9t\WO3bHHyJIFtfGW{YYTpc45{NCCjbnSgZ4VtdCCvaXfyZZRqd25iYX7kJIlvfmG|aX;uJIlv\HWlZXSgZpkhWkuLUDDrco9kc2Sxd36= Ml\oNlU6OTV2M{C=
HASMC MlfzSpVv[3Srb36gRZN{[Xl? NVT4blVJOS5{NT21JO69VQ>? NEmyNmYzOCCvaX6= NX3nR2VtTE2VT9Mg MmrObY5pcWKrdIOgdE0pYSlvU2TBWE0yNDNuNTDzbYdv[Wy|wrC= NXTOcXJYOjV6NEm2NlI>
H9c2  NFTkZY1HfW6ldHnvckBCe3OjeR?= M2LzXFIwOTBizszN NXfxbJpHOiCq NIHCSGpFVVORwrC= NFfT[Gxi[nKxZ3H0[ZPDqHSqZTDjfZRweHKxdHXjeIl3\SCnZn\lZ5R{KG:oIFnMMVI4KGGpYXnud5QhW0h? NHvVN5IzPTh{MEmwOy=>
A431 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuyxsDPxE1? MkXtNuKhcA>? NGDHfmdjdG:la4OgSWdHNXKndnXyd4VlKGSnY4LlZZNmeyCrbjDj[YxtKH[rYXLpcIl1gQ>? NGOx[IkzPTd{MESzOS=>
A431 NGjCO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\SXVLDqM7:TR?= M1;YfFLDqGh? MlXpbY5kemWjc3XzJIlvKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIPobYtwdmmw NEX6UHYzPTd{MESzOS=>
SiHa MkXsR4VtdCCYaXHibYxqfHliQYPzZZk> M4TFXlUuPzVibl2= MUiyOOKhcMLi M330W5Npd3e|IH3vdpBpd2yxZ4mgc4Yh[SC2eYDpZ4FtKGGyb4D0c5Rq[yClZXzsJIFv\CCmb4PlMYRmeGWwZHXueEBtd3O|IH;mJINmdGxidnnhZoltcXS7wrC= NF\EeFUzPTV|OU[0OC=>
SiHa NY\sUIV{TnWwY4Tpc44hSXO|YYm= M{XQTlUuPzVibl2= MnXjNlTDqGkEoB?= NFnJbJRz\WS3Y3XzJJRp\cLicHjvd5Bpd3K7bHH0bY9vKGG2IITo[UB1gXKxc3nu[UBz\XOrZIXlJFcxPcLi MXGyOVU{QTZ2NB?=
ECA109 NUDIZYM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXjeYYxNTJyIN88US=> MnvTNlTDqGkEoB?= NX;meGRUUUN3ME21MlUxKM7:TR?= MYOyOVQ6OjR6MB?=
TE13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjieWVxOC1{MDFOwG0> NVzlfWNNOjUEoHlCpC=> NULOfo1GUUN3ME22MlE2yqEQvF2= NFf6PWozPTR7MkS4NC=>
KYSE150  M3rFZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\NdHJkOC1{MDFOwG0> M1W4NFI1yqCqwrC= MmDMTWM2OD1zMj62OOKh|ryP M3vXRVI2PDl{NEiw
ECA109 M3HtSmNtd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= NGX6PWgxNjYEoN88US=> MWCyOOKhcMLi MX7zeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= Mnu1NlU1QTJ2OEC=
TE13 M1TqV2Ntd26xZ3XubYMhW3W{dnn2ZYwhSXO|YYm= MoLwNE42yqEQvF2= M1vIOVI1yqCqwrC= NXHxN256e3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> NFqxOJAzPTR7MkS4NC=>
KYSE150  MVHDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 MmXzNE42yqEQvF2= MV:yOOKhcMLi Mo\Xd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= MnLkNlU1QTJ2OEC=
ECA109 Mkn0SpVv[3Srb36gRZN{[Xl? MkT0NE42yqEQvF2= NFi1OpEzPMLiaNMg MnLS[Y5p[W6lZYOgTXIucW6mdXPl[EBo\W6ncnH0bY9vKG:oIFTTRpM> NYTIfIszOjV2OUK0PFA>
PC3M-1E8 NFjn[XZHfW6ldHnvckBCe3OjeR?= NEXRNJozNjVxNT:xNEDPxE1? NH7iepIxNTRiaB?= MmnnbY5pcWKrdIOgeIhmKFOWQWSzJIFkfGm4YYTpc44hcW5iYTDkc5NmNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVzyqB? NH;U[2czPTJ4MUO2OS=>
PC3M-1E8 NF;he2FHfW6ldHnvckBCe3OjeR?= NWS0VVN2OTBizszN MVmyOEBp NHnVOYlld3ewcnXneYxifGW|IFLjcE15VCxic4Xyeol3cW5iYX7kJIMuVXml Mm\sNlUzPjF|NkW=
PC3M-1E8 NHX4fXlHfW6ldHnvckBCe3OjeR?= MYmxNEDPxE1? NGPNZoozPCCq MmPrbY5pcWKrdIOgTWwuPiCrbnT1Z4VlKFOWQWSzJIFkfGm4YYTpc44h[W6mIITo[UBKVC14LXnu[JVk\WRiU2TBWFMh[WO2aY\heIlwdg>? MVWyOVI3OTN4NR?=
PC3M-1E8 NIDIXnZEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 NF3oT|UzNjVxNT:xNEDPxE1? M3nHVolvcGmkaYTzxsB1cGViY3;sc456KG[xcn3heIlwdiC|aXfubYZq[2GwdHz5 MYmyOVI3OTN4NR?=
MDA-MB-231 MX7GeY5kfGmxbjDBd5NigQ>? NUO0Zo91OjBizszN M4O5V|IhcA>? NWq5[oN7\XiqaXLpeJMhW26jaXygZY5lKEVvY3HkbIVzcW5iZYjwdoV{e2mxbh?= NEjJOZMzPTF3M{O0PS=>
H9c2 M4\FXGZ2dmO2aX;uJGF{e2G7 M4rMNFIxKML3TR?= NYrEXYZxOzBibXnu Mo[1SG1UV8Li NUPUb4du[WKxbHnzbIV{KHC{b4Dv[o9tNWmwZIXj[YQhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDic5RpKHOnckS3N{BidmRidHjyN|A5 M4HrPVI2OTB3ME[3
HaCaT  NGHxdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHsNVAhyrWP NVvtT|VHOjBibXnu MkjGSG1UV8Li MXPlcohidmOnczDzc5Ji\mWwaXKtJIFv\CC|dX7peIlvcWJvaX7keYNm\CCpcn;3eIghcW6qaXLpeIlwdg>? NXWyZWRGOjVyMUO5NFc>
Caki-1 M4HWVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7zbY4yOCEEtV2= NUPMUHVwOjBibXnu NHnF[YtFVVORwrC= M{SzT4VvcGGwY3XzJJNwemGoZX7pZk0h[W6mIIP1col1cW6rYj3pcoR2[2WmIHfyc5d1cCCrbnjpZol1cW:w NEDjeG0zPTBzM{mwOy=>
HaCaT  NGfpfXlCeG:ydH;zbZMhSXO|YYm= M{HNblExKML3TR?= MVGyNEBucW5? NIS0fo9FVVORwrC= NEXKeIFqdmO{ZXHz[ZMheHKxcH;yeIlwdnNib3[gZZBweHSxdHnjJINmdGy|IHT1[UB1dyC2cnXheI1mdnRid3n0bEB{d3KjZnXubYIhd3Jic4XubZRqdmmk MWmyOVAyOzlyNx?=
FHL-primed hNSCs MX3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NIOwe2gxNjB{LUWg{txO MV:3NkBp NULxemdbdGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w Ml[zNlQ6PDV2M{S=
ELL-primed hNSCs MlzoR4VtdCCYaXHibYxqfHliQYPzZZk> MYiwMlAzNTVizszN NUPrVpMxPzJiaB?= MUDs[YFleyC2bzD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDheEBpcWeqIHPvcoNmdnS{YYTpc44> MXiyOFk1PTR|NB?=
SS MUHD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M4fFV|EuOTBizszN NFzuSok4OiCq NEm1SZlFVVOR NWO1VmNL[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> M4LJflI1PzV4MUGx
SeAx  MVLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MWSxMVExKM7:TR?= NWSxcFM6PzJiaB?= NVvESpVoTE2VTx?= NFrubnVk[XW|ZYOgZUBld3OnLXTldIVv\GWwdDDpcohq[mm2aX;uJI9nKHSqZTD2bYFjcWyrdIpCpC=> NYizeWQ5OjR5NU[xNVE>
HuT-78 M4TPW2NmdGxiVnnhZoltcXS7IFHzd4F6 MnzzNU0yOCEQvF2= Mo[5O|IhcA>? MYfEUXNQ MUPjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= NHTIcoEzPDd3NkGxNS=>
CD4+ MnfORZBweHSxc3nzJGF{e2G7 M1PLVFEx6oDLzszt MknYNlQhcA>? M2juOWROW09? NYrRVWhOcW6mdXPld{BieG:ydH;zbZMhe3S{b37ncJk> NVL2dVhPOjR5NU[xNVE>
MCF-7 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLhelIxNjR4OT2zMlc2KM7:TR?= Moe3OUBl NIDYfXFz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= Mln2NlQ4OjhyN{i=
MCF-7/LCC1 NXLn[ZFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUWwMlQ3QS1|Lke1JO69VQ>? M4HCNlUh\A>? MV7y[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? M1HIbVI1PzJ6MEe4
MCF-7/LCC9 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT2W3ExNjR4OT2zMlc2KM7:TR?= M1rY[lUh\A>? NIfadVdz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= NYCxWGhwOjR5MkiwO|g>
HaCaT MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuxNEDDvU1? Ml\LNlAhdWmw NXvYXJJYTE2VT9Mg NVXZXnA2\W6qYX7j[ZMh\X[ncn;sbY12ey2rbnT1Z4VlKGOnbHyg[5Jwf3SqIHnubIljcXSrb36= MWeyOFQzOzF|MR?=
HaCaT MnfYRZBweHSxc3nzJGF{e2G7 NV\vbYVROTBiwsXN M2HIe|IxKG2rbh?= MYHEUXNQyqB? Mmfr[Y5p[W6lZYOgeIhmKGGyb4D0c5Rq[yCnZn\lZ5R{KG:oIHX2[ZJwdGmvdYO= M4TI[|I1PDJ|MUOx
MDA-MB-231 MV3GeY5kfGmxbjDBd5NigQ>? Mor5NVAhyrWP MVWyOEBp NELWVWhFVVORwrC= M37MSZJm\HWlZYOgVE1UXEGWMzDlfJBz\XO|aX;u NF;IflQzPDN5NkW4Oi=>
SUM-159 NGjGc4FHfW6ldHnvckBCe3OjeR?= M2fQcVExKML3TR?= NX\3TZc2OjRiaB?= NV:2O|dRTE2VT9Mg MVny[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= MVGyOFM4PjV6Nh?=
SK-BR-3 MmjKSpVv[3Srb36gRZN{[Xl? MWKxNEDDvU1? MU[yOEBp M2HUVWROW00EoB?= NIftNYZz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> NEW4Z40zPDN5NkW4Oi=>
MCF7-HER2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK5[ZNDOC1zMDFOwG0> M1HaTFQ5KGh? NHy2PFRFVVOR MoDDbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= Mm\6NlQzQTd3MEi=
MCF7-HER2 NUS3T4RFTnWwY4Tpc44hSXO|YYm= MUK1JO69VQ>? M4G0ZVI1KGh? MUfEUXNQ MlnI[IlucW6rc3jld{BUd3hvMjygU4N1NTRuIHHu[EB{dHWpIHX4dJJme3Orb36= MWqyOFI6PzVyOB?=
MCF7-HER2 NFza[4NHfW6ldHnvckBCe3OjeR?= NHrRd4I2KM7:TR?= NUjqOGw3OjRiaB?= NW\VWGhYTE2VTx?= MmHu[IVkemWjc3XzJJRp\SCneIDy[ZN{cW:wIHzleoVteyCxZjDFUXQhdWG{a3Xyd{whfmmvZX70bY4h[W6mIIPseYc> MViyOFI6PzVyOB?=
MCF7-HER2 M3\6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\DZXQyPSEQvF2= MmfINlQhcA>? MVHEUXNQ Mnrs[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiClb33ibY5m\CC5aYToJGhmemOncITpci=> MXuyOFI6PzVyOB?=
HMECs  MYjGeY5kfGmxbjDBd5NigQ>? Mo\lNVAh|ryP MXeyJIg> NFq5NZBqdmirYnn0d{BKTk8QsdMgcYVlcWG2ZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJHNVSVRzLDDTWGFVOiCjbnSgV3RCXDN? MoHlNlQzOTF|Mke=
HTR8/SVneo M4rBXmZ2dmO2aX;uJGF{e2G7 M1K3XVHDqM7:TdMg MUmxxsBp MUfzeZBxemW|c3XkJG9UVS2rbnT1Z4VlKFOWQWSzJJBpd3OyaH;yfYxifGmxbh?= M1SwbFI1ODZyMkSx
HTR8/SVneo NUnHTmhOTnWwY4Tpc44hSXO|YYm= NGKzeWwxNjVxMdMg{txOyqB? MYi0PEBp M3e0SpJme3SxcnXzJJRp\SCneIDy[ZN{cW:wIH;mJGUu[2GmaHXybY4he3WycILld5Nm\CCkeTDPV20> NXHYWpNsOjRyNkCyOFE>
HTR8/SVneo NFT5UJVHfW6ldHnvckBCe3OjeR?= NWnCfnhWOcLizszNxsA> NHywPWo1QCCq MXjzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyCvaXfyZZRqd25iYomgU3NOyqB? M2D3e|I1ODZyMkSx
C13* NX6wb|lPSXCxcITvd4l{KEG|c3H5 M2HZPVAuOTBizszN NWn0TndiOjRxNEigbC=> M1zFcolv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy MlzKNlM6PjJ3NUi=
OV2008 MY\BdI9xfG:|aYOgRZN{[Xl? M4LvVVAuOTBizszN MYWyOE81QCCq M2e3Volv\HWlZYOgZZBweHSxc3nzJIlvKGFiZH;z[UBidmRidHnt[UBl\XCnbnTlcpQhdWGwbnXy NVPVS2U2OjN7NkK1OVg>
C13* M4jGVmFxd3C2b4Ppd{BCe3OjeR?= M1G5PFI1NzR6IHi= MUXlcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= NWDJfZFvOjN7NkK1OVg>
OV2008 NYWwSIhWSXCxcITvd4l{KEG|c3H5 NFLSepAzPC92ODDo Mlnr[Y5p[W6lZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZZBweHSxc3nz NX7ySpNmOjN7NkK1OVg>
W480  NYnSN5pTTnWwY4Tpc44hSXO|YYm= MmHnNk42NzFyIN88US=> MnXYN|AhdWmw NXjCXIZwTE2VTx?= Mn7Rd4Vve2m2aYrld{Bk\WyuczD0c{BkcGWvb4Lh[IlwfGincnHwfUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MWCyN|k{PDl5Mh?=
SW837 Mn32SpVv[3Srb36gRZN{[Xl? MVOyMlUwOTBizszN NEm3eZE{OCCvaX6= MWLEUXNQ MWnz[Y5{cXSrenXzJINmdGy|IITvJINp\W2xcnHkbY91cGW{YYD5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M2\YcFI{QTN2OUey
T24 NX\yWHZYTnWwY4Tpc44hSXO|YYm= MUCyM|ExNzJyIN88US=> MkX4NlQhcA>? MUfjZZV{\XNiZH;z[U1l\XCnbnTlcpQhcW6qaXLpeIlwdiCxZjD0bIUhS1iFTEGyMYlv\HWlZXSgbY5kemWjc3Wgc4YhcW64YXTpcoch[2WubIO= M{TTWlI{PTJ4MEe5
CNE1 MVnGeY5kfGmxbjDBd5NigQ>? MW[yNEDDvU1? MnPROFghcA>? NUnhVVU5[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NFzRdWUzOzN6MkmxOC=>
CNE2 M3vlcWZ2dmO2aX;uJGF{e2G7 M1LQdFIxKML3TR?= MWi0PEBp NGfWd4djdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= NHq5THczOzN6MkmxOC=>
HONE1 MXTGeY5kfGmxbjDBd5NigQ>? NYjnZY1QOjBiwsXN M2\hXVQ5KGh? MnnDZoxw[2u|IITo[UBKVC14IHnuZ5Jm[XOnZDDwbI9{eGixconsZZRqd25ib3[gV5RifDN? NYDRfnFNOjN|OEK5NVQ>
CNE1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fX[VQh|ryP MkjCd4lodmmoaXPhcpRtgSC{ZXT1Z4V{KGOnbHygeoli[mmuaYT5 MlPHNlM{QDJ7MUS=
CNE1 MYDGeY5kfGmxbjDBd5NigQ>? NXjHeFBMOC1{MDFOwG0> Mkn6NE01KGh? NWr1fIdvcW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> NUS3OlNXOjN|OEK5NVQ>
CNE2 MkDDSpVv[3Srb36gRZN{[Xl? M3m4OlAuOjBizszN NV24NFk1OC12IHi= M3T6OIlvcGmkaYTzJHN1[XR|IHHjeIl3[XSrb36gbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy NEDnOIUzOzN6MkmxOC=>
HONE1 NFvqWWxHfW6ldHnvckBCe3OjeR?= MnH5NE0zOCEQvF2= NH;sdmExNTRiaB?= MX3pcohq[mm2czDTeIF1OyCjY4TpeoF1cW:wIHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NGLFOVIzOzN6MkmxOC=>
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PCNs NX;6eVFQS2WubDDWbYFjcWyrdImgRZN{[Xl? NGTFdJkxNTFyIN88US=> NHG1O3E4OiCq M3e1fWROW09? MnLubY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? MljDNlU1OzZ4OEK=
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RAW264.7 MmXJSpVv[3Srb36gRZN{[Xl? MX6xNEDPxE1? MWexNkBp MXfhZpJw\2G2ZYOgeIhmKG2UTlGg[ZhxemW|c3nvcpMhd2ZiSlHLNkwhW1SDVEGsJHNVSVR{LDDhcoQhW1SDVEOgbY5lfWOnZDDifUBFV05iYX7kJHQuOiC2b4jpci=> MkDINlI1PTR2M{G=
RAW264.7 MYHBdI9xfG:|aYOgRZN{[Xl? NYrHeVFQPS9zMDFOwG0> MV:0OUBucW5? MUnlcohidmOnczD0c5hqdnNiaX7keYNm\CCjcH;weI9{cXNiYX7kJG1OWCCub4Pz Ml;wNlI1PTR2M{G=
SW480 M1rSd2NmdGxiVnnhZoltcXS7IFHzd4F6 MXe1M|ExNzJyIN88US=> MYG3NkBp Mn7DbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? NFHTdZozOTlyMEO5Oy=>
HCT116 M4LCdGNmdGxiVnnhZoltcXS7IFHzd4F6 MYC1M|ExNzJyIN88US=> MkO2O|IhcA>? NVHne4J7cW6qaXLpeJMh[2WubDD2bYFjcWyrdImgc4YhfGinIFHMSGgsN0OGMUOzL:Kh[2WubIO= NXW1c29TOjF7MECzPVc>
DLD-1  NVrnXpg1S2WubDDWbYFjcWyrdImgRZN{[Xl? NGXHcWk2NzFyL{KwJO69VQ>? NH[xdFU4OiCq Mn3QbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? Mn21NlE6ODB|OUe=
SNU387  NHHwWZlE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MlK4NlDDqM7:TdMg NX6xOYtFOjRiaB?= NXG4b5pOemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= NIq0N5YzOTNzMUm3OS=>
SNU398 MVXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MmXTNlDDqM7:TdMg M{HwZVI1KGh? NUToWG9NemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= NFrGNm4zOTNzMUm3OS=>
HepG2 M2XCVmNmdGxiVnnhZoltcXS7IFHzd4F6 MX2yNOKh|ryPwrC= Mn;QNlQhcA>? MonVdoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? M4focFIyOzFzOUe1
Huh-7 MnjMR4VtdCCYaXHibYxqfHliQYPzZZk> M2H6[|IxyqEQvF5CpC=> MUWyOEBp MnzLdoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? NYPvXFVMOjF|MUG5O|U>
VSMC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfOUJQ{NzVxMUCg{txO NFHCVXQ{OCCvaX6= Mle4SG1UVw>? NUn6S2RNeHKndnXueJMhWESJRj2gZY5lKHSqcn;tZolvNW2nZHnheIVlKF[VTVOgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NH7N[pIzODh2N{OwOi=>
MDA-MB-231 MlTSRZBweHSxc3nzJGF{e2G7 MoDBNVAh|ryP MV2yOEBp MofpSG1UV8Li NGrJS21qdmS3Y3XzJIFxd3C2b4Ppdy=> NYL4WGRUOTdzMUSwNFU>
MDA-MB-435S MXzBdI9xfG:|aYOgRZN{[Xl? M4DBPFExKM7:TR?= MoqzNlQhcA>? NEjlc2tFVVORwrC= M4O3SIlv\HWlZYOgZZBweHSxc3nz MlTNNVcyOTRyMEW=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+H2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID