Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017. Stattic purchased from Selleck.

    LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

  • (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 NYHr[XozTnWwY4Tpc44hSXO|YYm= NFq4WlgyOOLCid88US=> MYG05qCKcA>? MYTy[ZZmenOnczD0bIUh\W[oZXP0d{Bw\iCLTD2yOy=> NEfCbWczPjN|OU[zNy=>
NPC  M2fyPWZ2dmO2aX;uJGF{e2G7 MVWwMVcvPSEEtV2= NXPrZlV[[WKxbHnzbIV{KEWPVD3sbYtmKG2xbHXjeYxieiCjbITldoF1cW:wczygZY5lKGOnbHygcYloemG2aX;uJIFv\CCrbo\hd4lwdiCrbnT1Z4VlKGK7IGLLTXAhc26xY3vkc5dv NUnsdmJrOjV7MUW0N|A>
HASMC Ml\FSpVv[3Srb36gRZN{[Xl? NUS5cFBCOS5{NT21JO69VQ>? MnPzNlAhdWmw MoOzSG1UV8Li NH7WfVFqdmirYnn0d{BxNSi\KT3TWGFVNTFuMzy1JJNq\26jbIRCpC=> NELIZlMzPTh2OU[yNi=>
H9c2  NF70S5VHfW6ldHnvckBCe3OjeR?= NEHYOFYzNzFyIN88US=> MYOyJIg> MV;EUXNQyqB? M1PNW4Fjem:pYYTld:KhfGinIHP5eI9xem:2ZXP0bZZmKGWoZnXjeJMhd2ZiSVytNlch[WejaX7zeEBUUA>? NUXKOHI1OjV6MkC5NFc>
A431 NE[3UYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGyxsDPxE1? NXjDWnRSOsLiaB?= NU\KS4dC[myxY3vzJGVITi2{ZY\ldpNm\CCmZXPy[YF{\XNiaX6gZ4VtdCC4aXHibYxqfHl? MXeyOVczODR|NR?=
A431 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n4UVLDqM7:TR?= MVeyxsBp NVH3cpB7cW6lcnXhd4V{KGmwIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNpcWuxbnnu NH7CbHczPTd{MESzOS=>
SiHa NInlOHdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NHe1Omc2NTd3IH7N NV;u[3p{OjUEoHlCpC=> M4nMWZNpd3e|IH3vdpBpd2yxZ4mgc4Yh[SC2eYDpZ4FtKGGyb4D0c5Rq[yClZXzsJIFv\CCmb4PlMYRmeGWwZHXueEBtd3O|IH;mJINmdGxidnnhZoltcXS7wrC= M2exOFI2PTN7NkS0
SiHa NEfJXldHfW6ldHnvckBCe3OjeR?= M{LGNlUuPzVibl2= MYWyOOKhcMLi NGO1dnpz\WS3Y3XzJJRp\cLicHjvd5Bpd3K7bHH0bY9vKGG2IITo[UB1gXKxc3nu[UBz\XOrZIXlJFcxPcLi MYOyOVU{QTZ2NB?=
ECA109 M4\zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i5VVAuOjBizszN NX21XZA1OjUEoHlCpC=> MlPRTWM2OD13LkWwJO69VQ>? M1\MRlI2PDl{NEiw
TE13 M4DCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TMOlAuOjBizszN MX2yOOKhcMLi NVLBcnUzUUN3ME22MlE2yqEQvF2= NHv2XYEzPTR7MkS4NC=>
KYSE150  NXSzcpBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWqwMVIxKM7:TR?= MXOyOOKhcMLi NUfaeFR[UUN3ME2xNk43PMLizszN MlX5NlU1QTJ2OEC=
ECA109 MnfGR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= NX3JcGUyOC53wrFOwG0> NGf5TJAzPMLiaNMg M4njOpN2eHC{ZYPz[ZMhfGinIHPsc45w\2WwaXOg[o9zdWG2aX;u M4flZlI2PDl{NEiw
TE13 MUDDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 NITtPG0xNjYEoN88US=> MoXONlTDqGkEoB?= MmnOd5VxeHKnc4Pld{B1cGViY3zvco9o\W6rYzDmc5Ju[XSrb36= NFy1WIMzPTR7MkS4NC=>
KYSE150  MmToR4xwdm:pZX7pZ{BUfXK4aY\hcEBCe3OjeR?= MmnYNE42yqEQvF2= M2ewRlI1yqCqwrC= MXPzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= NV[3eY5VOjV2OUK0PFA>
ECA109 M4T3SWZ2dmO2aX;uJGF{e2G7 MmnuNE42yqEQvF2= MYCyOOKhcMLi MkDZ[Y5p[W6lZYOgTXIucW6mdXPl[EBo\W6ncnH0bY9vKG:oIFTTRpM> M2e3WFI2PDl{NEiw
PC3M-1E8 MXLGeY5kfGmxbjDBd5NigQ>? MlnXNk42NzVxMUCg{txO M33DW|AuPCCq MYLpcohq[mm2czD0bIUhW1SDVEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZLDqA>? MVmyOVI3OTN4NR?=
PC3M-1E8 M4XEO2Z2dmO2aX;uJGF{e2G7 NVXWW4tJOTBizszN M4n0eFI1KGh? NIf0O25ld3ewcnXneYxifGW|IFLjcE15VCxic4Xyeol3cW5iYX7kJIMuVXml NXfmUXltOjV{NkGzOlU>
PC3M-1E8 MWnGeY5kfGmxbjDBd5NigQ>? MkP6NVAh|ryP M2HnXVI1KGh? MmjxbY5pcWKrdIOgTWwuPiCrbnT1Z4VlKFOWQWSzJIFkfGm4YYTpc44h[W6mIITo[UBKVC14LXnu[JVk\WRiU2TBWFMh[WO2aY\heIlwdg>? NXfqe3Z7OjV{NkGzOlU>
PC3M-1E8 MUPDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 M3zIOFIvPS93L{GwJO69VQ>? MWPpcohq[mm2c9MgeIhmKGOxbH;ufUBnd3KvYYTpc44he2mpbnnmbYNidnSueR?= MWOyOVI3OTN4NR?=
MDA-MB-231 NFewfJlHfW6ldHnvckBCe3OjeR?= MY[yNEDPxE1? M{j2R|IhcA>? NWfIcGRR\XiqaXLpeJMhW26jaXygZY5lKEVvY3HkbIVzcW5iZYjwdoV{e2mxbh?= MWCyOVE2OzN2OR?=
H9c2 NVnQWIZlTnWwY4Tpc44hSXO|YYm= MoD2NlAhyrWP MmDuN|AhdWmw NX;JfpVOTE2VT9Mg NFrmXG9i[m:uaYPo[ZMheHKxcH;mc4wucW6mdXPl[EBCU1RicHjvd5Bpd3K7bHH0bY9vKGG2IHLveIghe2W{NEezJIFv\CC2aIKzNFg> MYeyOVExPTB4Nx?=
HaCaT  MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPjZ2dkOTBiwsXN MojMNlAhdWmw NEHPd4xFVVORwrC= NWTxUJlS\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= MYKyOVAyOzlyNx?=
Caki-1 NVfvWId7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXydI8yOCEEtV2= MlLVNlAhdWmw M4nqS2ROW00EoB?= Mmjz[Y5p[W6lZYOgd49z[W[nbnniMUBidmRic4XubZRqdmmkLXnu[JVk\WRiZ4Lve5RpKGmwaHnibZRqd25? MnW3NlUxOTN7MEe=
HaCaT  NIDkN5lCeG:ydH;zbZMhSXO|YYm= MV6xNEDDvU1? M3ywdlIxKG2rbh?= MVLEUXNQyqB? MXzpcoNz\WG|ZYOgdJJweG:{dHnvcpMhd2ZiYYDvdJRwfGmlIHPlcIx{KGS3ZTD0c{B1emWjdH3lcpQhf2m2aDDzc5Ji\mWwaXKgc5Ihe3WwaYTpcolj MWCyOVAyOzlyNx?=
FHL-primed hNSCs MoDKR4VtdCCYaXHibYxqfHliQYPzZZk> NV[w[Fl{OC5yMj21JO69VQ>? MWq3NkBp M2\BOIxm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? MnPXNlQ6PDV2M{S=
ELL-primed hNSCs NIPhPFZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MXWwMlAzNTVizszN NGjMSmQ4OiCq NUPkTnJvdGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w MXiyOFk1PTR|NB?=
SS NGXEZpFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3n2PVEuOTBizszN Mn:0O|IhcA>? NEjUPJlFVVOR MXLjZZV{\XNiYTDkc5NmNWSncHXu[IVvfCCrbnjpZol1cW:wIH;mJJRp\SC4aXHibYxqfHoEoB?= MlHONlQ4PTZzMUG=
SeAx  NInue5VE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGLaSGYyNTFyIN88US=> NGHpPW04OiCq NHj2VHVFVVOR NVj3d|Z7[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> NGPUNIszPDd3NkGxNS=>
HuT-78 NIH2eI1E\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1rBblEuOTBizszN MkSwO|IhcA>? M4\5bGROW09? NH3JR2Vk[XW|ZYOgZUBld3OnLXTldIVv\GWwdDDpcohq[mm2aX;uJI9nKHSqZTD2bYFjcWyrdIpCpC=> Mn;INlQ4PTZzMUG=
CD4+ NXW2UINRSXCxcITvd4l{KEG|c3H5 MVixNQKBkc7:bR?= NH\Db3ozPCCq NIHyXm5FVVOR MWDpcoR2[2W|IHHwc5B1d3OrczDzeJJwdmeueR?= MmjwNlQ4PTZzMUG=
MCF-7 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvnbIYxNjR4OT2zMlc2KM7:TR?= MlrVOUBl NFH6VYdz\WS3Y3XzJINmdGxiboXtZoVzKHOrZ37p[olk[W62bIm= NYjDTmRuOjR5MkiwO|g>
MCF-7/LCC1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqwMlQ3QS1|Lke1JO69VQ>? NGq5SHI2KGR? MYDy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? MlrZNlQ4OjhyN{i=
MCF-7/LCC9 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf2NE41PjlvMz63OUDPxE1? MWK1JIQ> MonUdoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 MlyxNlQ4OjhyN{i=
HaCaT MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HUblExKML3TR?= M{PyVFIxKG2rbh?= NVrvO4lyTE2VT9Mg NHzQfIdmdmijbnPld{BmfmW{b3zpcZV{NWmwZIXj[YQh[2WubDDndo94fGhiaX7obYJqfGmxbh?= MkjVNlQ1OjNzM{G=
HaCaT MWnBdI9xfG:|aYOgRZN{[Xl? MkTuNVAhyrWP M{TNV|IxKG2rbh?= MkPLSG1UV8Li NVG0fYlk\W6qYX7j[ZMhfGinIHHwc5B1d3SrYzDl[oZm[3S|IH;mJIV3\XKxbHnteZM> NX\qWXFHOjR2MkOxN|E>
MDA-MB-231 MXPGeY5kfGmxbjDBd5NigQ>? MlLKNVAhyrWP NYPSO3ptOjRiaB?= NYLvOW5[TE2VT9Mg M1zlWZJm\HWlZYOgVE1UXEGWMzDlfJBz\XO|aX;u NGnDSZYzPDN5NkW4Oi=>
SUM-159 NX3GcJMzTnWwY4Tpc44hSXO|YYm= M3rEbVExKML3TR?= NITTOHczPCCq NIjqSJZFVVORwrC= M36zb5Jm\HWlZYOgVE1UXEGWMzDlfJBz\XO|aX;u NVnK[YI3OjR|N{[1PFY>
SK-BR-3 MoHVSpVv[3Srb36gRZN{[Xl? NIPvdI4yOCEEtV2= NXLQbXd2OjRiaB?= Mn:ySG1UV8Li NV:5O3o2emWmdXPld{BRNVOWQWSzJIV5eHKnc4Ppc44> M3XsNVI1Ozd4NUi2
MCF7-HER2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVywMVExKM7:TR?= NWf5fXZ4PDhiaB?= NGHBVphFVVOR MXjpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= Mmm5NlQzQTd3MEi=
MCF7-HER2 Mk\tSpVv[3Srb36gRZN{[Xl? NILiWGQ2KM7:TR?= NUXUeHljOjRiaB?= MnjnSG1UVw>? M{D2coRqdWmwaYPo[ZMhW2:6LUKsJG9kfC12LDDhcoQhe2y3ZzDlfJBz\XO|aX;u NYLtOJg1OjR{OUe1NFg>
MCF7-HER2 NFzFelBHfW6ldHnvckBCe3OjeR?= MnvFOUDPxE1? MkfoNlQhcA>? MWXEUXNQ M3vVc4Rm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDs[ZZmdHNib3[gSW1VKG2jcnvldpMtKH[rbXXueIlvKGGwZDDzcJVo M{nn[VI1Ojl5NUC4
MCF7-HER2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:1JO69VQ>? NVXpe3d7OjRiaB?= MXzEUXNQ Mojx[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiClb33ibY5m\CC5aYToJGhmemOncITpci=> NYjB[HF3OjR{OUe1NFg>
HMECs  NGTYTZRHfW6ldHnvckBCe3OjeR?= NFruSmEyOCEQvF2= NIfIfJgzKGh? M1jSZ4lvcGmkaYTzJGlHVs7zwrDt[YRq[XSnZDDwbI9{eGixconsZZRqd25ib3[gV3RCXDFuIGPURXQzKGGwZDDTWGFVOw>? MV[yOFIyOTN{Nx?=
HTR8/SVneo M4O2VmZ2dmO2aX;uJGF{e2G7 NWr3cZlCOcLizszNxsA> NVXqOGJzOcLiaB?= M2PScZN2eHC{ZYPz[YQhV1OPLXnu[JVk\WRiU2TBWFMheGixc4Doc5J6dGG2aX;u MlzBNlQxPjB{NEG=
HTR8/SVneo NFrnS|lHfW6ldHnvckBCe3OjeR?= Mn3QNE42NzIEoN88UeKh NWjXT3FZPDhiaB?= Ml7XdoV{fG:{ZYOgeIhmKGW6cILld5Nqd25ib3[gSU1k[WSqZYLpckB{fXCycnXzd4VlKGK7IF;TUS=> MoP2NlQxPjB{NEG=
HTR8/SVneo M17rO2Z2dmO2aX;uJGF{e2G7 M3\Id|HDqM7:TdMg MmnuOFghcA>? NIX0cVF{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczDtbYdz[XSrb36gZpkhV1OPwrC= MX[yOFA3ODJ2MR?=
C13* MkD5RZBweHSxc3nzJGF{e2G7 NW\RPVN1OC1zMDFOwG0> M4\wOVI1NzR6IHi= NI\sNJpqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> M374UFI{QTZ{NUW4
OV2008 NUm2e3QySXCxcITvd4l{KEG|c3H5 Mn6wNE0yOCEQvF2= M3XhbVI1NzR6IHi= NFzGSHJqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> MnXPNlM6PjJ3NUi=
C13* NVHlVWNvSXCxcITvd4l{KEG|c3H5 M1;FN|I1NzR6IHi= M3rVcoVvcGGwY3XzJINqe3CuYYTpck1qdmS3Y3XkJIFxd3C2b4Ppdy=> MYGyN|k3OjV3OB?=
OV2008 NFXycIVCeG:ydH;zbZMhSXO|YYm= NUOzS2dWOjRxNEigbC=> MmrZ[Y5p[W6lZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZZBweHSxc3nz M2\oTFI{QTZ{NUW4
W480  NEG5[YhHfW6ldHnvckBCe3OjeR?= Ml\YNk42NzFyIN88US=> NVHRdWtGOzBibXnu NUjJVJQzTE2VTx?= Mo[1d4Vve2m2aYrld{Bk\WyuczD0c{BkcGWvb4Lh[IlwfGincnHwfUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M4LqTVI{QTN2OUey
SW837 NEXnVmFHfW6ldHnvckBCe3OjeR?= M3;nN|IvPS9zMDFOwG0> M{K0PVMxKG2rbh?= NVy1fnZtTE2VTx?= NITyeYJ{\W6|aYTpfoV{KGOnbHzzJJRwKGOqZX3vdoFlcW:2aHXyZZB6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M3\aPVI{QTN2OUey
T24 MnLlSpVv[3Srb36gRZN{[Xl? M2fTTVIwOTBxMkCg{txO NVnjTWF3OjRiaB?= NITh[VRk[XW|ZYOg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGViQ2jDUFEzNWmwZIXj[YQhcW6lcnXhd4Uhd2ZiaX72ZYRqdmdiY3XscJM> NUKyUINXOjN3Mk[wO|k>
CNE1 M2HtWWZ2dmO2aX;uJGF{e2G7 M3LXNlIxKML3TR?= NHnUWII1QCCq NHizZlZjdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= NYPHe5psOjN|OEK5NVQ>
CNE2 Ml\OSpVv[3Srb36gRZN{[Xl? MYCyNEDDvU1? MoG2OFghcA>? NIGzfYhjdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= M1;ROFI{Ozh{OUG0
HONE1 M4nERmZ2dmO2aX;uJGF{e2G7 NHSxe48zOCEEtV2= MV[0PEBp NIPx[JdjdG:la4OgeIhmKEmOLU[gbY5kemWjc3XkJJBpd3OyaH;yfYxifGmxbjDv[kBUfGG2Mx?= MYOyN|M5OjlzNB?=
CNE1 M{jue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTndo01KM7:TR?= NWnZN49Ie2mpbnnmbYNidnSueTDy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 M1PmPVI{Ozh{OUG0
CNE1 NFHLPXVHfW6ldHnvckBCe3OjeR?= M1P0TVAuOjBizszN M3;BXVAuPCCq M3yxV4lvcGmkaYTzJHN1[XR|IHHjeIl3[XSrb36gbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy NHva[ZIzOzN6MkmxOC=>
CNE2 NWjKOpk{TnWwY4Tpc44hSXO|YYm= NU\2bYZpOC1{MDFOwG0> NWjpcIhSOC12IHi= NHfBNXFqdmirYnn0d{BUfGG2MzDhZ5RqfmG2aX;uJIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> M2\sWFI{Ozh{OUG0
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C666-1  M{ftXWNmdGxiVnnhZoltcXS7IFHzd4F6 MWmwMlUuPjRizszN MXy0PEBp Mo\td5VxeHKnc4Pld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NF;XRlMzOzN6MkmxOC=>
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CNE2 NEDUOFlCeG:ydH;zbZMhSXO|YYm= M3XsZ|ExKML3TdMg NWHsfm86PDhiaB?= NHLiWnVqdmS3Y3XzJIFxd3C2b4Ppd:Kh NIrDc4UzOzN6MkmxOC=>
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HONE1 MUPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MlnTNU8zKM7:TR?= NInYWFU1QCCq MXTz[Y5{cXSrenWgZ4VtdHNidH:gdoFlcW:2aHXyZZB6 MYmyN|M5OjlzNB?=
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CT26 M3viN2Z2dmO2aX;uJGF{e2G7 M3Ox[|IxKG2P NYjLXHVyOSCq NH\GdVd{fXCycnXzd4V{KEiJRj3pcoR2[2WmIG\FS2Yh\XiycnXzd4lwdsLi M3rBUlI{OjN|MU[z
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Cal33 NXq1cIRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC2TWM2OD1{LkK4NkDDuSByLkSyN{DPxE1uIFfJOVA:OS5|NEmgxtEhOC5|NkOg{txO NW\BSpk4OjJ5N{C4PVk>
UM-SCC-22B M3;wWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGry[phKSzVyPUKuOlQ5KMLzIECuOVQzKM7:TTygS2k2OD1zLkOyNEDDuSByLkKwOEDPxE1? MkCyNlI4PzB6OUm=
UM-SCC-17B NHLyVWhHfW6ldHnvckBCe3OjeR?= NV2zOIE2OC1|MDFOwG0> NWPpXVJWOC1{NDDo NE\WUFNqdmirYnn0d{BUXEGWMzDhZ5RqfmG2aX;uJIRwe2ViYX7kJJRqdWViZHXw[Y5l\W62bIm= NEf4OpUzOjd5MEi5PS=>
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Cal33 M3PWZmZ2dmO2aX;uJGF{e2G7 MkDLNE0{OCEQvF2= NYi0PVhzOC1{NDDo NVnvZng{cW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 MlzQNlI4PzB6OUm=
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U-373MG NHTDdZRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NU\KdYtnOC1zMDFOwG0> NYrkbZZFPzJiaB?= MoHCSG1UVw>? NGrkW4JqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 MXyyOVQ{PjZ6Mh?=
SH-SY5Y MX3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGf6O20xNTFyIN88US=> MXK3NkBp M2qxN2ROW09? NE\2cJlqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 M17y[|I2PDN4Nkiy
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Neuro-2a NEL0XndE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NWj1S5Z1OC1zMDFOwG0> Mn2xO|IhcA>? NF;OOI9FVVOR M3HxdYlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? NWL4TXVYOjV2M{[2PFI>
PCNs M3;qc2NmdGxiVnnhZoltcXS7IFHzd4F6 MVOwMVExKM7:TR?= MnzLO|IhcA>? M4TjZWROW09? MVTpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MYGyOVQ{PjZ6Mh?=
PGCs MmH1R4VtdCCYaXHibYxqfHliQYPzZZk> MmizNE0yOCEQvF2= M4TwbVczKGh? Mn7xSG1UVw>? NXf0V3hKcW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MmHUNlU1OzZ4OEK=
RAW264.7 M3[1WmZ2dmO2aX;uJGF{e2G7 NHfXepYyOCEQvF2= NYn5SIx3OTJiaB?= NU\3PXN1[WK{b3fheIV{KHSqZTDtVm5CKGW6cILld5Nqd26|IH;mJGpCUzJuIGPURXQyNCCVVFHUNkwh[W6mIGPURXQ{KGmwZIXj[YQh[nliRF;OJIFv\CCWLUKgeI95cW5? M1LuPFIzPDV2NEOx
RAW264.7 M2f0OWFxd3C2b4Ppd{BCe3OjeR?= M{jyW|UwOTBizszN M4W1NFQ2KG2rbh?= M{DUXoVvcGGwY3XzJJRwgGmwczDpcoR2[2WmIHHwc5B1d3OrczDhcoQhVU2SIHzvd5M> MkDFNlI1PTR2M{G=
SW480 MlvLR4VtdCCYaXHibYxqfHliQYPzZZk> MnHsOU8yOC9{MDFOwG0> MVG3NkBp M4r6ZolvcGmkaYTzJINmdGxidnnhZoltcXS7IH;mJJRp\SCDTFTIL{9ETDF|MzxCpINmdGy| NGLBeVkzOTlyMEO5Oy=>
HCT116 M{L0NWNmdGxiVnnhZoltcXS7IFHzd4F6 M2nWcVUwOTBxMkCg{txO M3LuT|czKGh? MYXpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCxZjD0bIUhSUyGSDuvR2QyOzNtwrDj[Yxtew>? Mlm0NlE6ODB|OUe=
DLD-1  NUfSWIFTS2WubDDWbYFjcWyrdImgRZN{[Xl? NHzTVGc2NzFyL{KwJO69VQ>? MVK3NkBp MoHWbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? NH\DNZAzOTlyMEO5Oy=>
SNU387  M33YR2NmdGxiVnnhZoltcXS7IFHzd4F6 Mke2NlDDqM7:TdMg MVmyOEBp M3nQbJJm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MXyyNVMyOTl5NR?=
SNU398 NGfNb41E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYPJTnVvOjEEoN88UeKh M2\sblI1KGh? NH33VYRz\WS3Y3XzJINmdGxidnnhZoltcXS7 MX:yNVMyOTl5NR?=
HepG2 M4nJdWNmdGxiVnnhZoltcXS7IFHzd4F6 NYrkWXUzOjEEoN88UeKh M4TL[FI1KGh? NF;QNWxz\WS3Y3XzJINmdGxidnnhZoltcXS7 M3LmeFIyOzFzOUe1
Huh-7 NF;jOGZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NX\FT5FsOjEEoN88UeKh M16yNFI1KGh? M2O1OZJm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MYGyNVMyOTl5NR?=
VSMC MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmzM|UwOTBizszN NWfMR45POzBibXnu M2Lo[mROW09? MnHXdJJmfmWwdIOgVGRITi1iYX7kJJRpem:vYnnuMY1m\GmjdHXkJHZUVUNicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NGHGemwzODh2N{OwOi=>
MDA-MB-231 Mmr6RZBweHSxc3nzJGF{e2G7 NEDPXZIyOCEQvF2= NH3ZV4IzPCCq MV7EUXNQyqB? M{DVWIlv\HWlZYOgZZBweHSxc3nz NIL1XIoyPzFzNECwOS=>
MDA-MB-435S M3jyNWFxd3C2b4Ppd{BCe3OjeR?= MYCxNEDPxE1? M{nwc|I1KGh? MYnEUXNQyqB? NV6xUZJwcW6mdXPld{BieG:ydH;zbZM> Mn\hNVcyOTRyMEW=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+H2O
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID