Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

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In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock
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4 Customer Reviews

  • The cell viability was determined in HEC-1B cells treated with MPA, insulin, GSK1904529A or Stattic or with silenced DHCR24.

    Sci Rep, 2017, 7:41404. Stattic purchased from Selleck.

    (B) Western blotting showing the hepaCAM expression and the phosphorylation level of STAT3, ERK and AKT in cells treated with IL-6 (20 ng/mL) for 24 h with or without the pretreatment of three respective inhibitors, Stattic (10 μM), U0126 (5 μM) and MK-2206 (1 μM)

    Cell Signal, 2017, 32:48-58. Stattic purchased from Selleck.

  • LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MljQSpVv[3Srb36gRZN{[Xl? MVKxNQKBkc7:TR?= MWS05qCKcA>? Ml7QdoV3\XK|ZYOgeIhmKGWoZnXjeJMhd2ZiSVytNlc> MYiyOlM{QTZ|Mx?=
NPC  MVnGeY5kfGmxbjDBd5NigQ>? MX2wMVcvPSEEtV2= M4PGboFjd2yrc3jld{BGVVRvbHnr[UBud2ynY4XsZZIh[Wy2ZYLheIlwdnNuIHHu[EBk\WyuIH3p[5JifGmxbjDhcoQhcW64YYPpc44hcW6mdXPl[EBjgSCUS1nQJItvd2OtZH;3ci=> NG\TTXQzPTlzNUSzNC=>
HASMC NU[4d3ZZTnWwY4Tpc44hSXO|YYm= M4fnR|EvOjVvNTFOwG0> NVjMfppTOjBibXnu NF\3[VlFVVORwrC= M2HsSolvcGmkaYTzJJAuMFlrLWPURXQuOSx|LEWgd4lodmGuc9Mg MVSyOVg1QTZ{Mh?=
H9c2  M1qzOWZ2dmO2aX;uJGF{e2G7 NG\WTGkzNzFyIN88US=> NW[1Vph6OiCq M2PhR2ROW00EoB?= NV\UeHJJ[WK{b3fheIV{yqC2aHWgZ5l1d3C{b4TlZ5RqfmViZX\m[YN1eyCxZjDJUE0zPyCjZ3HpcpN1KFOK MYmyOVgzODlyNx?=
A431 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuyxsDPxE1? MVmyxsBp NFLpOIJjdG:la4OgSWdHNXKndnXyd4VlKGSnY4LlZZNmeyCrbjDj[YxtKH[rYXLpcIl1gQ>? NIHUNFAzPTd{MESzOS=>
A431 Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzEXIEzyqEQvF2= MVWyxsBp MoG5bY5kemWjc3XzJIlvKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIPobYtwdmmw NHHtVIozPTd{MESzOS=>
SiHa Mn;PR4VtdCCYaXHibYxqfHliQYPzZZk> Ml7XOU04PSCwTR?= NGnBVlIzPMLiaNMg M{HOdZNpd3e|IH3vdpBpd2yxZ4mgc4Yh[SC2eYDpZ4FtKGGyb4D0c5Rq[yClZXzsJIFv\CCmb4PlMYRmeGWwZHXueEBtd3O|IH;mJINmdGxidnnhZoltcXS7wrC= MV2yOVU{QTZ2NB?=
SiHa NHPBXo5HfW6ldHnvckBCe3OjeR?= Mk\lOU04PSCwTR?= NFizSFAzPMLiaNMg MVfy[YR2[2W|IITo[eKheGixc4Doc5J6dGG2aX;uJIF1KHSqZTD0fZJwe2mwZTDy[ZNq\HWnIEewOeKh MoHaNlU2Ozl4NES=
ECA109 M{TMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jVNVAuOjBizszN MYGyOOKhcMLi NVezXJdSUUN3ME21MlUxKM7:TR?= NFuxfZEzPTR7MkS4NC=>
TE13 NIDGPINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fDeFAuOjBizszN NH23V3kzPMLiaNMg MYHJR|UxRTZwMUZCpO69VQ>? NWn0[5g5OjV2OUK0PFA>
KYSE150  MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;mNE0zOCEQvF2= NXy5R5BOOjUEoHlCpC=> MlrNTWM2OD1zMj62OOKh|ryP M4jGfFI2PDl{NEiw
ECA109 MYXDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 NInwXI0xNjYEoN88US=> Ml;vNlTDqGkEoB?= MXjzeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= MoLVNlU1QTJ2OEC=
TE13 MYHDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 NVjJN5V[OC53wrFOwG0> MnzONlTDqGkEoB?= NITadWt{fXCycnXzd4V{KHSqZTDjcI9vd2enbnnjJIZwem2jdHnvci=> NVPwPHZiOjV2OUK0PFA>
KYSE150  NHHre4ZEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 MlTNNE42yqEQvF2= NYjZN4tTOjUEoHlCpC=> MX;zeZBxemW|c3XzJJRp\SClbH;uc4dmdmmlIH\vdo1ifGmxbh?= M4nvc|I2PDl{NEiw
ECA109 M1u4emZ2dmO2aX;uJGF{e2G7 NF[1fG8xNjYEoN88US=> NGjGfXYzPMLiaNMg MWjlcohidmOnczDJVk1qdmS3Y3XkJIdmdmW{YYTpc44hd2ZiRGPCdy=> NHPmbGEzPTR7MkS4NC=>
PC3M-1E8 NYfneJBETnWwY4Tpc44hSXO|YYm= M4Hzb|IvPS93L{GwJO69VQ>? NVrPfm1COC12IHi= NFu2dWlqdmirYnn0d{B1cGViU2TBWFMh[WO2aY\heIlwdiCrbjDhJIRwe2VvIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XMEoB?= NGK5bYozPTJ4MUO2OS=>
PC3M-1E8 NHXp[XJHfW6ldHnvckBCe3OjeR?= MUWxNEDPxE1? MXGyOEBp M3jWWoRwf26{ZXf1cIF1\XNiQnPsMZhNNCC|dYL2bZZqdiCjbnSgZ{1OgWN? M4n2SlI2OjZzM{[1
PC3M-1E8 NWfReHZyTnWwY4Tpc44hSXO|YYm= M2HnVVExKM7:TR?= MnfGNlQhcA>? MUDpcohq[mm2czDJUE03KGmwZIXj[YQhW1SDVEOgZYN1cX[jdHnvckBidmRidHjlJGlNNTZvaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9v NFHNUnMzPTJ4MUO2OS=>
PC3M-1E8 NVPYSGx7S2yxbn;n[Y5q[yCVdYL2bZZidCCDc4PhfS=> MXWyMlUwPS9zMDFOwG0> M1e2folvcGmkaYTzxsB1cGViY3;sc456KG[xcn3heIlwdiC|aXfubYZq[2GwdHz5 MYSyOVI3OTN4NR?=
MDA-MB-231 NUXWeZpVTnWwY4Tpc44hSXO|YYm= MlTCNlAh|ryP MkHCNkBp M{LucIV5cGmkaYTzJHNv[WmuIHHu[EBGNWOjZHjldolvKGW6cILld5Nqd25? MmTHNlUyPTN|NEm=
H9c2 M2q5cmZ2dmO2aX;uJGF{e2G7 MW[yNEDDvU1? NFzXcHk{OCCvaX6= MmfZSG1UV8Li MXPhZo9tcXOqZYOgdJJweG:ob3ytbY5lfWOnZDDBT3QheGixc4Doc5J6dGG2aX;uJIF1KGKxdHigd4VzPDd|IHHu[EB1cHJ|MEi= MXyyOVExPTB4Nx?=
HaCaT  NEezcVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:4NmxpOTBiwsXN NGXOZokzOCCvaX6= MmW2SG1UV8Li NXS1RYRK\W6qYX7j[ZMhe2:{YX\lcoljNSCjbnSgd5VvcXSrbnniMYlv\HWlZXSg[5Jwf3SqIHnubIljcXSrb36= Mn7qNlUxOTN7MEe=
Caki-1 NYrCRXlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm2Z4NEOTBiwsXN M4HT[|IxKG2rbh?= NGS5NW9FVVORwrC= M3iye4VvcGGwY3XzJJNwemGoZX7pZk0h[W6mIIP1col1cW6rYj3pcoR2[2WmIHfyc5d1cCCrbnjpZol1cW:w NXr2[FhOOjVyMUO5NFc>
HaCaT  MWjBdI9xfG:|aYOgRZN{[Xl? MmW4NVAhyrWP NWD1fWUzOjBibXnu NEn4N45FVVORwrC= MYTpcoNz\WG|ZYOgdJJweG:{dHnvcpMhd2ZiYYDvdJRwfGmlIHPlcIx{KGS3ZTD0c{B1emWjdH3lcpQhf2m2aDDzc5Ji\mWwaXKgc5Ihe3WwaYTpcolj NVG5SnpxOjVyMUO5NFc>
FHL-primed hNSCs NG\YZoRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYr6eo1NOC5yMj21JO69VQ>? NXjkTJNLPzJiaB?= M4PpNIxm[WS|IITvJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JIF1KGirZ3igZ49v[2WwdILheIlwdg>? NV23NHNiOjR7NEW0N|Q>
ELL-primed hNSCs NWDpNYc6S2WubDDWbYFjcWyrdImgRZN{[Xl? NHzSSFkxNjB{LUWg{txO NYGwe29JPzJiaB?= MVjs[YFleyC2bzD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDheEBpcWeqIHPvcoNmdnS{YYTpc44> NYf0fVhpOjR7NEW0N|Q>
SS M1XvOGNmdGxiVnnhZoltcXS7IFHzd4F6 NHrBd5YyNTFyIN88US=> MWG3NkBp NWT1R|J7TE2VTx?= MlXMZ4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= NEXSWGIzPDd3NkGxNS=>
SeAx  NYTDVHo1S2WubDDWbYFjcWyrdImgRZN{[Xl? NYnYR2JMOS1zMDFOwG0> MlvzO|IhcA>? MkHUSG1UVw>? M2LEV4NifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg NYXhfZpUOjR5NU[xNVE>
HuT-78 MlTqR4VtdCCYaXHibYxqfHliQYPzZZk> MUOxMVExKM7:TR?= MWi3NkBp MVXEUXNQ M1nWXYNifXOnczDhJIRwe2VvZHXw[Y5l\W62IHnubIljcXSrb36gc4YhfGinII\pZYJqdGm2edMg M3PPbFI1PzV4MUGx
CD4+ NHjZcpVCeG:ydH;zbZMhSXO|YYm= Mn;SNVDjiIoQvH2= NV;EZmxkOjRiaB?= NUDMbolvTE2VTx?= M36ySIlv\HWlZYOgZZBweHSxc3nzJJN1em:wZ3z5 M4rycFI1PzV4MUGx
MCF-7 MlexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImzSoUxNjR4OT2zMlc2KM7:TR?= M3\POlUh\A>? NWXveVBbemWmdXPld{Bk\WyuIH71cYJmeiC|aXfubYZq[2GwdHz5 NVvINlk6OjR5MkiwO|g>
MCF-7/LCC1 NYnDfpZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInPOXoxNjR4OT2zMlc2KM7:TR?= MXS1JIQ> NVHwcoUyemWmdXPld{Bk\WyuIH71cYJmeiC|aXfubYZq[2GwdHz5 NUHyXll4OjR5MkiwO|g>
MCF-7/LCC9 NVvu[HJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX1NE41PjlvMz63OUDPxE1? NVfINVh1PSCm MXTy[YR2[2W|IHPlcIwhdnWvYnXyJJNq\26rZnnjZY51dHl? NHL6ZXEzPDd{OEC3PC=>
HaCaT M{PneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S2PVExKML3TR?= M33ac|IxKG2rbh?= NGT4fHRFVVORwrC= MlXN[Y5p[W6lZYOg[ZZmem:uaX31d{1qdmS3Y3XkJINmdGxiZ4Lve5RpKGmwaHnibZRqd25? NFXBRmUzPDR{M{GzNS=>
HaCaT NVj4bI1ESXCxcITvd4l{KEG|c3H5 NXzrPItwOTBiwsXN NXewS4FjOjBibXnu NFzpRXdFVVORwrC= MWflcohidmOnczD0bIUh[XCxcITveIlkKGWoZnXjeJMhd2ZiZY\ldo9tcW23cx?= NYLLbWFkOjR2MkOxN|E>
MDA-MB-231 NETJUYxHfW6ldHnvckBCe3OjeR?= NHHYUZcyOCEEtV2= Ml\JNlQhcA>? M4\XcGROW00EoB?= MnW3doVlfWOnczDQMXNVSVR|IHX4dJJme3Orb36= MVeyOFM4PjV6Nh?=
SUM-159 NELjSYVHfW6ldHnvckBCe3OjeR?= MmrmNVAhyrWP MX:yOEBp Mn7USG1UV8Li MnWxdoVlfWOnczDQMXNVSVR|IHX4dJJme3Orb36= MVyyOFM4PjV6Nh?=
SK-BR-3 Mk\YSpVv[3Srb36gRZN{[Xl? M3;XW|ExKML3TR?= NYHRWXFzOjRiaB?= NHrxT2ZFVVORwrC= MWDy[YR2[2W|IGCtV3RCXDNiZYjwdoV{e2mxbh?= MYeyOFM4PjV6Nh?=
MCF7-HER2 NFO2b|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PTNVAuOTBizszN MXq0PEBp NFGxWHFFVVOR MXzpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= M{jkTVI1Ojl5NUC4
MCF7-HER2 NYiwfXNOTnWwY4Tpc44hSXO|YYm= MVK1JO69VQ>? M1KybVI1KGh? MXnEUXNQ NUHhUmFN\GmvaX7pd4hmeyCVb4itNkwhV2O2LUSsJIFv\CC|bIXnJIV5eHKnc4Ppc44> NHTpOWQzPDJ7N{WwPC=>
MCF7-HER2 MW\GeY5kfGmxbjDBd5NigQ>? MWS1JO69VQ>? MnfkNlQhcA>? MYPEUXNQ NFnRTGFl\WO{ZXHz[ZMhfGinIHX4dJJme3Orb36gcIV3\Wy|IH;mJGVOXCCvYYLr[ZJ{NCC4aX3lcpRqdiCjbnSgd4x2\w>? NHPsUlEzPDJ7N{WwPC=>
MCF7-HER2 NXHyVXNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH2OUDPxE1? M4jLfFI1KGh? MlHQSG1UVw>? MXjlcohidmOnczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGOxbXLpcoVlKHerdHigTIVz[2WydHnu M1LRcFI1Ojl5NUC4
HMECs  NGjKSmFHfW6ldHnvckBCe3OjeR?= MlOyNVAh|ryP NF7Be5YzKGh? MljibY5pcWKrdIOgTWZP|rIEoH3l[IlifGWmIIDoc5NxcG:{eXzheIlwdiCxZjDTWGFVOSxiU2TBWFIh[W6mIGPURXQ{ MnmzNlQzOTF|Mke=
HTR8/SVneo M2XWZmZ2dmO2aX;uJGF{e2G7 MV6xxsDPxE4EoB?= MWixxsBp M4j2VJN2eHC{ZYPz[YQhV1OPLXnu[JVk\WRiU2TBWFMheGixc4Doc5J6dGG2aX;u NH;aUHAzPDB4MEK0NS=>
HTR8/SVneo MWfGeY5kfGmxbjDBd5NigQ>? NUnjfodkOC53L{JCpO69VcLi NFHZXFY1QCCq MXry[ZN1d3KnczD0bIUh\XiycnXzd4lwdiCxZjDFMYNi\GincnnuJJN2eHC{ZYPz[YQh[nliT2PN NFfrdHUzPDB4MEK0NS=>
HTR8/SVneo M3HS[WZ2dmO2aX;uJGF{e2G7 MWexxsDPxE4EoB?= NX;VeFBbPDhiaB?= M{naSZNq\26rZnnjZY51dHliaX7jdoVie2W|IH3p[5JifGmxbjDifUBQW04EoB?= NHzRUHUzPDB4MEK0NS=>
C13* M{PaPGFxd3C2b4Ppd{BCe3OjeR?= M2PiNFAuOTBizszN NWHTe5k1OjRxNEigbC=> NE\vZ2VqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51KG2jbn7ldi=> M3OydlI{QTZ{NUW4
OV2008 MVvBdI9xfG:|aYOgRZN{[Xl? NGPhSI8xNTFyIN88US=> M32ydVI1NzR6IHi= MoHEbY5lfWOnczDhdI9xfG:|aYOgbY4h[SCmb4PlJIFv\CC2aX3lJIRmeGWwZHXueEBu[W6wZYK= NXjnUJU1OjN7NkK1OVg>
C13* NXmxTW5iSXCxcITvd4l{KEG|c3H5 NVnOb2M{OjRxNEigbC=> MVPlcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= MWiyN|k3OjV3OB?=
OV2008 Mn\HRZBweHSxc3nzJGF{e2G7 NXfVboY5OjRxNEigbC=> MmTE[Y5p[W6lZYOgZ4l{eGyjdHnuMYlv\HWlZXSgZZBweHSxc3nz Ml\kNlM6PjJ3NUi=
W480  NEHyWVVHfW6ldHnvckBCe3OjeR?= M3;MOlIvPS9zMDFOwG0> NUfVTZBTOzBibXnu M1uwVmROW09? MWXz[Y5{cXSrenXzJINmdGy|IITvJINp\W2xcnHkbY91cGW{YYD5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M1fJTlI{QTN2OUey
SW837 NEHlPJdHfW6ldHnvckBCe3OjeR?= NVLHflJpOi53L{GwJO69VQ>? M{HRSlMxKG2rbh?= NUnxT|RUTE2VTx?= MmDkd4Vve2m2aYrld{Bk\WyuczD0c{BkcGWvb4Lh[IlwfGincnHwfUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NVTkemhzOjN7M{S5O|I>
T24 NW\UZXhSTnWwY4Tpc44hSXO|YYm= NV\VSHZsOi9zMD:yNEDPxE1? NH2yR4QzPCCq MVLjZZV{\XNiZH;z[U1l\XCnbnTlcpQhcW6qaXLpeIlwdiCxZjD0bIUhS1iFTEGyMYlv\HWlZXSgbY5kemWjc3Wgc4YhcW64YXTpcoch[2WubIO= NEW4OpUzOzV{NkC3PS=>
CNE1 MYPGeY5kfGmxbjDBd5NigQ>? M33Nc|IxKML3TR?= MVW0PEBp NXXkNYNv[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= M1fHRVI{Ozh{OUG0
CNE2 MV3GeY5kfGmxbjDBd5NigQ>? NGnvUZkzOCEEtV2= NEPRTYE1QCCq NUe4VoFM[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= M{HyNlI{Ozh{OUG0
HONE1 NW\GOoJGTnWwY4Tpc44hSXO|YYm= MUmyNEDDvU1? M{fYVFQ5KGh? NYLjdlV4[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= NYTX[IVFOjN|OEK5NVQ>
CNE1 M1PrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi1OEDPxE1? M4jobpNq\26rZnnjZY51dHlicnXkeYNmeyClZXzsJJZq[WKrbHn0fS=> NFKzNZIzOzN6MkmxOC=>
CNE1 NFL2SHVHfW6ldHnvckBCe3OjeR?= NHy1fIkxNTJyIN88US=> M3\HclAuPCCq NWK1e2VncW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> NWDXc|ROOjN|OEK5NVQ>
CNE2 NHLLZYRHfW6ldHnvckBCe3OjeR?= Mle1NE0zOCEQvF2= MX:wMVQhcA>? MWjpcohq[mm2czDTeIF1OyCjY4TpeoF1cW:wIHnuJIEh\G:|ZT2gZY5lKHSrbXWt[IVx\W6mZX70JI1idm6nch?= NYDSTVNsOjN|OEK5NVQ>
HONE1 M4C0XGZ2dmO2aX;uJGF{e2G7 NYH1fHRZOC1{MDFOwG0> MYWwMVQhcA>? M4C5fYlvcGmkaYTzJHN1[XR|IHHjeIl3[XSrb36gbY4h[SCmb4PlMUBidmRidHnt[U1l\XCnbnTlcpQhdWGwbnXy MWGyN|M5OjlzNB?=
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CNE1 MUfBdI9xfG:|aYOgRZN{[Xl? NHTlSGoyOCEEtV5CpC=> MXe0PEBp NIOyXo9qdmS3Y3XzJIFxd3C2b4Ppd:Kh NY\yVm81OjN|OEK5NVQ>
CNE2 M2LnWWFxd3C2b4Ppd{BCe3OjeR?= NYXSVnNCOTBiwsXNxsA> MVi0PEBp MYfpcoR2[2W|IHHwc5B1d3Orc9Mg NUT1OWoxOjN|OEK5NVQ>
HONE1 NGfnWJFCeG:ydH;zbZMhSXO|YYm= MknxNVAhyrWPwrC= NVXOWJc4PDhiaB?= MUPpcoR2[2W|IHHwc5B1d3Orc9Mg NWXIemp7OjN|OEK5NVQ>
CNE2 Mk\NR4VtdCCYaXHibYxqfHliQYPzZZk> MX2xM|Ih|ryP MonTOFghcA>? M3\UOJNmdnOrdHn6[UBk\WyuczD0c{Bz[WSrb4To[ZJieHl? NYDDdmk5OjN|OEK5NVQ>
HONE1 NHzoUohE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NFzXUHUyNzJizszN M4HMNlQ5KGh? NXjWd3BIe2Wwc3n0bZpmKGOnbHzzJJRwKHKjZHnveIhmemGyeR?= MnTFNlM{QDJ7MUS=
C666-1  M3TtemNmdGxiVnnhZoltcXS7IFHzd4F6 M{DpT|EwOiEQvF2= M3XzVVQ5KGh? NGj1eHh{\W6|aYTpfoUh[2WubIOgeI8hemGmaX;0bIVz[XC7 NUH0WYdXOjN|OEK5NVQ>
HEC-1A NFHCPI5HfW6ldHnvckBCe3OjeR?= NWPj[4wzOcLizszNxsA> M3fVflI1KGh? M{LP[GROW09? M2[1R4Jtd2OtczD0bIUhVVWFMkCt[Y5p[W6lZXSgbY53[XOrb36geJJq\2encnXkJIJ6KDFyJTDGRnM> MXuyN|I3OjJyOB?=
RL95-2 M1HrSGZ2dmO2aX;uJGF{e2G7 MmfQNeKh|ryPwrC= NUnEcXRFOjRiaB?= NVPMS3VCTE2VTx?= MYficI9kc3NidHjlJG1WSzJyLXXubIFv[2WmIHnueoF{cW:wIITybYdo\XKnZDDifUAyOCViRlLT MWOyN|I3OjJyOB?=
HEC-1A NYrJTGE1TnWwY4Tpc44hSXO|YYm= MX2xxsDPxE4EoB?= NGDkOGczPCCq NV3KXXd{TE2VTx?= MUPicI9kc3NidHjlJG1WSzJyLXXubIFv[2WmIHnueoF{cW:wIITybYdo\XKnZDDifUBGT0cEoB?= MUmyN|I3OjJyOB?=
RL95-2 NUXwc|Q3TnWwY4Tpc44hSXO|YYm= NFP1XnYyyqEQvF5CpC=> Mn\wNlQhcA>? NGXTWJZFVVOR MkL5Zoxw[2u|IITo[UBOXUN{MD3lcohidmOnZDDpcpZie2mxbjD0dolo\2W{ZXSgZpkhTUeIwrC= NHTqN2wzOzJ4MkKwPC=>
CT26 M3radmZ2dmO2aX;uJGF{e2G7 MVOyNEBuVQ>? MXuxJIg> M2SzU5N2eHC{ZYPz[ZMhUEeILXnu[JVk\WRiVlXHSkBmgHC{ZYPzbY9vyqB? NGr5WJIzOzJ|M{G2Ny=>
UM-SCC-17B NEDMSpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XhWGlEPTB;Mj61OlIhyrFiMD60NFkh|ryPLDDHTVUxRTFwMke5JOKyKDBwMUm0JO69VQ>? M1rBZVIzPzdyOEm5
OSC-19 NVn5VVJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LwO2lEPTB;Mz60PFEhyrFiMD65OVMh|ryPLDDHTVUxRTFwM{[2JOKyKDBwN{ewJO69VQ>? MoDoNlI4PzB6OUm=
Cal33 M1nNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliyTWM2OD1{LkK4NkDDuSByLkSyN{DPxE1uIFfJOVA:OS5|NEmgxtEhOC5|NkOg{txO M4\JNVIzPzdyOEm5
UM-SCC-22B NUTLTZZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjOdZFKSzVyPUKuOlQ5KMLzIECuOVQzKM7:TTygS2k2OD1zLkOyNEDDuSByLkKwOEDPxE1? Mo\vNlI4PzB6OUm=
UM-SCC-17B NH\UV25HfW6ldHnvckBCe3OjeR?= NInVc4MxNTNyIN88US=> MlTNNE0zPCCq NYrpSYtrcW6qaXLpeJMhW1SDVEOgZYN1cX[jdHnvckBld3OnIHHu[EB1cW2nIHTldIVv\GWwdHz5 MUKyNlc4ODh7OR?=
OSC-19 MXrGeY5kfGmxbjDBd5NigQ>? NVfoTlZoOC1|MDFOwG0> MUSwMVI1KGh? MXHpcohq[mm2czDTWGFVOyCjY4TpeoF1cW:wIHTvd4Uh[W6mIITpcYUh\GWyZX7k[Y51dHl? NHe2dokzOjd5MEi5PS=>
Cal33 NGKyNFFHfW6ldHnvckBCe3OjeR?= MljPNE0{OCEQvF2= NH\FT3gxNTJ2IHi= M1;tWYlvcGmkaYTzJHNVSVR|IHHjeIl3[XSrb36g[I9{\SCjbnSgeIlu\SCmZYDlcoRmdnSueR?= NIDnTnAzOjd5MEi5PS=>
UM-SCC-22B M{fIWWZ2dmO2aX;uJGF{e2G7 MoPNNE0{OCEQvF2= MoDLNE0zPCCq Moj3bY5pcWKrdIOgV3RCXDNiYXP0bZZifGmxbjDkc5NmKGGwZDD0bY1mKGSncHXu[IVvfGy7 NV7jOI5nOjJ5N{C4PVk>
U-87MG M2nLfGNmdGxiVnnhZoltcXS7IFHzd4F6 Mmr2NE0yOCEQvF2= M3H4W|czKGh? M3Hre2ROW09? MUnpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 MUCyOVQ{PjZ6Mh?=
U-373MG Mke0R4VtdCCYaXHibYxqfHliQYPzZZk> MofYNE0yOCEQvF2= M13TWVczKGh? NYfhUFk1TE2VTx?= MV\pcohq[mm2czDj[YxtKH[rYXLpcIl1gSCmb4PlJIRmeGWwZHXueIx6 M2GwVlI2PDN4Nkiy
SH-SY5Y NGi1fFRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M{PzNFAuOTBizszN MlyyO|IhcA>? NX\tRpIyTE2VTx?= NIPvbZJqdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 NVqwd|FTOjV2M{[2PFI>
Tu-9648 NXeyV4RyS2WubDDWbYFjcWyrdImgRZN{[Xl? M{XGcFAuOTBizszN M{jR[|czKGh? MYDEUXNQ NYjLVXh4cW6qaXLpeJMh[2WubDD2bYFjcWyrdImg[I9{\SCmZYDlcoRmdnSueR?= MnfRNlU1OzZ4OEK=
Neuro-2a Ml\hR4VtdCCYaXHibYxqfHliQYPzZZk> MUWwMVExKM7:TR?= NFz5foo4OiCq MVTEUXNQ NFKzOm1qdmirYnn0d{Bk\WyuII\pZYJqdGm2eTDkc5NmKGSncHXu[IVvfGy7 NH\BZZgzPTR|Nk[4Ni=>
PCNs NYnQ[nN3S2WubDDWbYFjcWyrdImgRZN{[Xl? NGPTTmYxNTFyIN88US=> NXnDTlZuPzJiaB?= NV3Yc44xTE2VTx?= MoDrbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHliZH;z[UBl\XCnbnTlcpRtgQ>? MojmNlU1OzZ4OEK=
PGCs MnzWR4VtdCCYaXHibYxqfHliQYPzZZk> MomxNE0yOCEQvF2= MVm3NkBp NI\z[3dFVVOR M{m4OIlvcGmkaYTzJINmdGxidnnhZoltcXS7IHTvd4Uh\GWyZX7k[Y51dHl? MVqyOVQ{PjZ6Mh?=
RAW264.7 NUK4e2dxTnWwY4Tpc44hSXO|YYm= MVmxNEDPxE1? MYexNkBp NVLSOnNz[WK{b3fheIV{KHSqZTDtVm5CKGW6cILld5Nqd26|IH;mJGpCUzJuIGPURXQyNCCVVFHUNkwh[W6mIGPURXQ{KGmwZIXj[YQh[nliRF;OJIFv\CCWLUKgeI95cW5? M4K2PFIzPDV2NEOx
RAW264.7 NUKzSoJ3SXCxcITvd4l{KEG|c3H5 MVO1M|ExKM7:TR?= NXTROYszPDVibXnu MYflcohidmOnczD0c5hqdnNiaX7keYNm\CCjcH;weI9{cXNiYX7kJG1OWCCub4Pz NWf5coo{OjJ2NUS0N|E>
SW480 NGjlOXNE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MmD6OU8yOC9{MDFOwG0> M{LQNlczKGh? MUDpcohq[mm2czDj[YxtKH[rYXLpcIl1gSCxZjD0bIUhSUyGSDuvR2QyOzNtwrDj[Yxtew>? NELXU3YzOTlyMEO5Oy=>
HCT116 M2TmZmNmdGxiVnnhZoltcXS7IFHzd4F6 MlXxOU8yOC9{MDFOwG0> NUn5e2ZVPzJiaB?= Mo\NbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? MkTTNlE6ODB|OUe=
DLD-1  NFHmWIpE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MWm1M|ExNzJyIN88US=> M2nFV|czKGh? M1TTN4lvcGmkaYTzJINmdGxidnnhZoltcXS7IH;mJJRp\SCDTFTIL{9ETDF|MzxCpINmdGy| MoLvNlE6ODB|OUe=
SNU387  MVvD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2TB[VIxyqEQvF5CpC=> M1G4cVI1KGh? MkPBdoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? M3ywN|IyOzFzOUe1
SNU398 M{HZdWNmdGxiVnnhZoltcXS7IFHzd4F6 M{PzclIxyqEQvF5CpC=> MWWyOEBp MnnVdoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? MViyNVMyOTl5NR?=
HepG2 NV\QdllJS2WubDDWbYFjcWyrdImgRZN{[Xl? MnXKNlDDqM7:TdMg NGTWPIUzPCCq NILoflZz\WS3Y3XzJINmdGxidnnhZoltcXS7 MmfUNlE{OTF7N{W=
Huh-7 NEm4fopE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MlnaNlDDqM7:TdMg MkjQNlQhcA>? MUfy[YR2[2W|IHPlcIwhfmmjYnnsbZR6 MUSyNVMyOTl5NR?=
VSMC MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYizM|UwOTBizszN MVqzNEBucW5? NVvS[ZB5TE2VTx?= M4TIc5Bz\X[nboTzJHBFT0ZvIHHu[EB1cHKxbXLpck1u\WSrYYTl[EBXW02FIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MWSyNFg1PzNyNh?=
MDA-MB-231 NIrLZ4VCeG:ydH;zbZMhSXO|YYm= MmrUNVAh|ryP NF\WTZozPCCq MoPLSG1UV8Li NEf6PY9qdmS3Y3XzJIFxd3C2b4Ppdy=> NYjlbm1EOTdzMUSwNFU>
MDA-MB-435S MUjBdI9xfG:|aYOgRZN{[Xl? MmnENVAh|ryP MVqyOEBp NUi4UlVzTE2VT9Mg NWO3TYtpcW6mdXPld{BieG:ydH;zbZM> NWHzbYVyOTdzMUSwNFU>

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:

[1]

+ Expand

High-Throughput Screening and FluorescencePolarization Assays:

Screening is performed at approximately 30 °C. The specificity ofscreening hits is validated in analogous assays for binding of thetest compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of therespective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM).Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research:

[2]

+ Expand
  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method:

    MTS


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Ly3 parental NOD/SCID IL2R null xenograft
  • Formulation: --
  • Dosages: 3.75 mg/kg every day
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+H2O
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID