Stattic

Catalog No.S7024

Stattic Chemical Structure

Molecular Weight(MW): 211.19

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 170 In stock

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2 Customer Reviews

  • LN229 cells were treated with vehicle or the small molecule STAT3 inhibitor Stattic and analyzed for cell migration (top panel) or cell invasion (bottom panel) by DAPI staining of nuclei. Bar graphs show quantification of cell motility.

    J Biol Chem 2013 288(8), 5553-61. Stattic purchased from Selleck.

    Western blot analysis of p-STAT3, total STAT3, ABCA1 and ABCG1 levels in cells pretreated with DMSO or Stattic (10 uM) for 1 hr before and during stimulation with rDKK1 in cells transfected with STAT3 siRNA or negative control, and rDKK1 added into the supernatant.

    FEBS Lett 2014 10.1016/j.febslet.2014.11.023. Stattic purchased from Selleck.

Purity & Quality Control

Choose Selective STAT Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
Features Stattic is the first non-peptide small molecule with inhibitory activity against STAT3 SH2 domain regardless of the STAT3 phosphorylation state in vitro.
Targets
STAT3 [1]
(Cell-free assay)
5.1 μM
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H9c2 MlTLSpVv[3Srb36gRZN{[Xl? MXixNQKBkc7:TR?= MojtOQKBkWh? NX3nWG53emW4ZYLz[ZMhfGinIHXm[oVkfHNib3[gTWwuOjd? NXe5WnZnOjZ|M{m2N|M>
NPC  M4r3T2Z2dmO2aX;uJGF{e2G7 M3m1SlAuPy53INM1US=> NVf4doZS[WKxbHnzbIV{KEWPVD3sbYtmKG2xbHXjeYxieiCjbITldoF1cW:wczygZY5lKGOnbHygcYloemG2aX;uJIFv\CCrbo\hd4lwdiCrbnT1Z4VlKGK7IGLLTXAhc26xY3vkc5dv Ml76NlU6OTV2M{C=
HASMC NWn2V5ZKTnWwY4Tpc44hSXO|YYm= MmK0NU4zPS13IN88US=> NV\BZ|ZDOjBibXnu MWrEUXNQyqB? M13EU4lvcGmkaYTzJJAuMFlrLWPURXQuOSx|LEWgd4lodmGuc9Mg NH\OeIYzPTh2OU[yNi=>
H9c2  NFvDNnJHfW6ldHnvckBCe3OjeR?= MWGyM|ExKM7:TR?= NW\v[3ViOiCq M{LPfWROW00EoB?= MVXhZpJw\2G2ZYRCpJRp\SCleYTvdJJwfGWldHn2[UBm\m[nY4TzJI9nKEmOLUK3JIFo[Wmwc4SgV2g> NWnyW455OjV6MkC5NFc>
A431 M4r6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv1PHZUOsLizszN NF\ESJIzyqCq NYHHeGRZ[myxY3vzJGVITi2{ZY\ldpNm\CCmZXPy[YF{\XNiaX6gZ4VtdCC4aXHibYxqfHl? MWqyOVczODR|NR?=
A431 NUT1WWtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3GWWw2OsLizszN NXnIS5dsOsLiaB?= NWnxNXp{cW6lcnXhd4V{KGmwIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNpcWuxbnnu NV:2U|BtOjV5MkC0N|U>
SiHa NI\Hc|JE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M{nQfFUuPzVibl2= NHPnSHMzPMLiaNMg NGLKc|l{cG:5czDtc5JxcG:ub3f5JI9nKGFidInwbYNidCCjcH;weI91cWNiY3XscEBidmRiZH;z[U1l\XCnbnTlcpQhdG:|czDv[kBk\WyuII\pZYJqdGm2edMg M{HjNlI2PTN7NkS0
SiHa NWXjWllzTnWwY4Tpc44hSXO|YYm= MnXlOU04PSCwTR?= NGD1OJMzPMLiaNMg NWHaUIlFemWmdXPld{B1cGYEoIDoc5NxcG:{eXzheIlwdiCjdDD0bIUhfHm{b4PpcoUhemW|aXT1[UA4ODYEoB?= Ml;5NlU2Ozl4NES=
ECA109 MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn1NE0zOCEQvF2= MYWyOOKhcMLi MWrJR|UxRTVwNUCg{txO NV\PfWh{OjV2OUK0PFA>
TE13 M1O1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P6c|AuOjBizszN MUCyOOKhcMLi NIq3U3hKSzVyPU[uNVXDqM7:TR?= NWTEV3ZqOjV2OUK0PFA>
KYSE150  MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfNRpdwOC1{MDFOwG0> MkTSNlTDqGkEoB?= MkX0TWM2OD1zMj62OOKh|ryP NVLXNI11OjV2OUK0PFA>
ECA109 MYXDcI9vd2enbnnjJHN2en[rdnHsJGF{e2G7 M4rue|AvPcLizszN NIrPc3kzPMLiaNMg NI[zdYR{fXCycnXzd4V{KHSqZTDjcI9vd2enbnnjJIZwem2jdHnvci=> MXeyOVQ6OjR6MB?=
TE13 NHjPVmtEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 M123[lAvPcLizszN MnrENlTDqGkEoB?= NX\vRlNne3WycILld5NmeyC2aHWgZ4xwdm:pZX7pZ{Bnd3KvYYTpc44> MVyyOVQ6OjR6MB?=
KYSE150  NHPYW45EdG:wb3flcolkKFO3co\peoFtKEG|c3H5 MoXZNE42yqEQvF2= MUSyOOKhcMLi M3XsXpN2eHC{ZYPz[ZMhfGinIHPsc45w\2WwaXOg[o9zdWG2aX;u MXOyOVQ6OjR6MB?=
ECA109 NU\ERXhtTnWwY4Tpc44hSXO|YYm= NHHwN3AxNjYEoN88US=> MX[yOOKhcMLi NFLWWYFmdmijbnPld{BKWi2rbnT1Z4VlKGenbnXyZZRqd25ib3[gSHNDew>? M1rGcFI2PDl{NEiw
PC3M-1E8 MmrQSpVv[3Srb36gRZN{[Xl? MmTxNk42NzVxMUCg{txO MWWwMVQhcA>? MoLNbY5pcWKrdIOgeIhmKFOWQWSzJIFkfGm4YYTpc44hcW5iYTDkc5NmNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVzyqB? MX2yOVI3OTN4NR?=
PC3M-1E8 NF;Vdo1HfW6ldHnvckBCe3OjeR?= NYm2bXFsOTBizszN NGrpPGEzPCCq M{naZoRwf26{ZXf1cIF1\XNiQnPsMZhNNCC|dYL2bZZqdiCjbnSgZ{1OgWN? NFWxbYUzPTJ4MUO2OS=>
PC3M-1E8 NYLwcnFQTnWwY4Tpc44hSXO|YYm= NFn1UosyOCEQvF2= M4HmeVI1KGh? MUjpcohq[mm2czDJUE03KGmwZIXj[YQhW1SDVEOgZYN1cX[jdHnvckBidmRidHjlJGlNNTZvaX7keYNm\CCVVFHUN{Bi[3SrdnH0bY9v NYrZTWFVOjV{NkGzOlU>
PC3M-1E8 NFLhNYVEdG:wb3flcolkKFO3co\peoFtKEG|c3H5 M2PP[VIvPS93L{GwJO69VQ>? MkDLbY5pcWKrdIRCpJRp\SClb3zvcpkh\m:{bXH0bY9vKHOrZ37p[olk[W62bIm= NIPQVXozPTJ4MUO2OS=>
MDA-MB-231 NVn5dXB7TnWwY4Tpc44hSXO|YYm= Mn;JNlAh|ryP NX;1T5A5OiCq MUnlfIhq[mm2czDTcoFqdCCjbnSgSU1k[WSqZYLpckBmgHC{ZYPzbY9v MkG1NlUyPTN|NEm=
H9c2 Mnz3SpVv[3Srb36gRZN{[Xl? NV7Rd2ZZOjBiwsXN M3\1OFMxKG2rbh?= MWLEUXNQyqB? NWrsOYo4[WKxbHnzbIV{KHC{b4Dv[o9tNWmwZIXj[YQhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDic5RpKHOnckS3N{BidmRidHjyN|A5 NE\qR3AzPTFyNUC2Oy=>
HaCaT  M1jyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXHcoNmOTBiwsXN MnzYNlAhdWmw NEnadJdFVVORwrC= M{f0bYVvcGGwY3XzJJNwemGoZX7pZk0h[W6mIIP1col1cW6rYj3pcoR2[2WmIHfyc5d1cCCrbnjpZol1cW:w Mnu5NlUxOTN7MEe=
Caki-1 NHvabnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlexNVAhyrWP M4SycVIxKG2rbh?= Ml7YSG1UV8Li M3nifYVvcGGwY3XzJJNwemGoZX7pZk0h[W6mIIP1col1cW6rYj3pcoR2[2WmIHfyc5d1cCCrbnjpZol1cW:w NW\NfnhQOjVyMUO5NFc>
HaCaT  MkOwRZBweHSxc3nzJGF{e2G7 Ml\ZNVAhyrWP M2\Md|IxKG2rbh?= MlX1SG1UV8Li MYnpcoNz\WG|ZYOgdJJweG:{dHnvcpMhd2ZiYYDvdJRwfGmlIHPlcIx{KGS3ZTD0c{B1emWjdH3lcpQhf2m2aDDzc5Ji\mWwaXKgc5Ihe3WwaYTpcolj Mn;SNlUxOTN7MEe=
FHL-primed hNSCs MnzUR4VtdCCYaXHibYxqfHliQYPzZZk> Mn\lNE4xOi13IN88US=> M3vFWFczKGh? NWnyRWNsdGWjZIOgeI8hfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[XRiaHnnbEBkd26lZX70doF1cW:w NFzRSZEzPDl2NUSzOC=>
ELL-primed hNSCs MmLhR4VtdCCYaXHibYxqfHliQYPzZZk> M1;NdlAvODJvNTFOwG0> MnzUO|IhcA>? MlPIcIVi\HNidH:geIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZZQhcGmpaDDjc45k\W62cnH0bY9v NWSxbHhDOjR7NEW0N|Q>
SS NIjWbG5E\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1:3NlEuOTBizszN NY\Nd2RSPzJiaB?= M2X4dmROW09? MoDKZ4F2e2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGVidnnhZoltcXS7wrC= M3TQTVI1PzV4MUGx
SeAx  MXTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NU\3SXdTOS1zMDFOwG0> MV[3NkBp Ml\ESG1UVw>? NU\rUG5Z[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> NHi1epYzPDd3NkGxNS=>
HuT-78 MUfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M3nQ[lEuOTBizszN M2fXc|czKGh? M4TjfWROW09? NU\CWmRC[2G3c3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5pcWKrdHnvckBw\iC2aHWgeoli[mmuaYT5xsA> NXG0U4t1OjR5NU[xNVE>
CD4+ Mnu2RZBweHSxc3nzJGF{e2G7 MlH1NVDjiIoQvH2= M4TCblI1KGh? NX3IOoZxTE2VTx?= Mn7mbY5lfWOnczDhdI9xfG:|aYOgd5Rzd26pbIm= NGDJO3kzPDd3NkGxNS=>
MCF-7 NXfNfZR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnWeZMxOC52NkmtN{44PSEQvF2= Mnz6OUBl MkP3doVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 NF74Tm0zPDd{OEC3PC=>
MCF-7/LCC1 MkHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M136VlAvPDZ7LUOuO|Uh|ryP MXK1JIQ> M3zyOJJm\HWlZYOgZ4VtdCCwdX3i[ZIhe2mpbnnmbYNidnSueR?= MXOyOFczQDB5OB?=
MCF-7/LCC9 NWi0TJljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnUWGtlOC52NkmtN{44PSEQvF2= NVfhUIJJPSCm MorldoVlfWOnczDj[YxtKG63bXLldkB{cWewaX\pZ4FvfGy7 M135elI1PzJ6MEe4
HaCaT MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfiN4gyOCEEtV2= MVmyNEBucW5? MmrMSG1UV8Li M4TQZYVvcGGwY3XzJIV3\XKxbHnteZMucW6mdXPl[EBk\WyuIHfyc5d1cCCrbnjpZol1cW:w NEnrPW8zPDR{M{GzNS=>
HaCaT NXLMZ5QzSXCxcITvd4l{KEG|c3H5 MXWxNEDDvU1? MoXQNlAhdWmw MUjEUXNQyqB? NVjuWZFK\W6qYX7j[ZMhfGinIHHwc5B1d3SrYzDl[oZm[3S|IH;mJIV3\XKxbHnteZM> M4\aN|I1PDJ|MUOx
MDA-MB-231 MnvYSpVv[3Srb36gRZN{[Xl? NInjOZcyOCEEtV2= NFTzU3ozPCCq MXTEUXNQyqB? NFPSUmZz\WS3Y3XzJHAuW1SDVEOg[ZhxemW|c3nvci=> NU\HUZl3OjR|N{[1PFY>
SUM-159 Mk\CSpVv[3Srb36gRZN{[Xl? MVSxNEDDvU1? NEWxVFkzPCCq NHr0R|RFVVORwrC= NX7QPHVqemWmdXPld{BRNVOWQWSzJIV5eHKnc4Ppc44> MWmyOFM4PjV6Nh?=
SK-BR-3 NHmxcolHfW6ldHnvckBCe3OjeR?= MlvRNVAhyrWP Ml;FNlQhcA>? MWHEUXNQyqB? MkmwdoVlfWOnczDQMXNVSVR|IHX4dJJme3Orb36= NEn4Om0zPDN5NkW4Oi=>
MCF7-HER2 M1LkdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX5WGIyOC1zMDFOwG0> NWT6fWZ6PDhiaB?= M3\PdWROW09? NX;PWJY5cW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> NYPseJpNOjR{OUe1NFg>
MCF7-HER2 NES0doVHfW6ldHnvckBCe3OjeR?= MUe1JO69VQ>? MnvXNlQhcA>? M1KxemROW09? NV:2THU2\GmvaX7pd4hmeyCVb4itNkwhV2O2LUSsJIFv\CC|bIXnJIV5eHKnc4Ppc44> NYHoUGo5OjR{OUe1NFg>
MCF7-HER2 M1ezNGZ2dmO2aX;uJGF{e2G7 M2jEd|Uh|ryP M37ZeVI1KGh? NWXZVmNyTE2VTx?= M3KwR4Rm[3KnYYPld{B1cGViZYjwdoV{e2mxbjDs[ZZmdHNib3[gSW1VKG2jcnvldpMtKH[rbXXueIlvKGGwZDDzcJVo M3;rPVI1Ojl5NUC4
MCF7-HER2 M2LMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPJOUDPxE1? MUKyOEBp NUPuUWdDTE2VTx?= NFTuWG1mdmijbnPld{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHPvcYJqdmWmIIfpeIghUGW{Y3XweIlv NITyeYIzPDJ7N{WwPC=>
HMECs  NH\RNFdHfW6ldHnvckBCe3OjeR?= MYmxNEDPxE1? MVyyJIg> M3vB[olvcGmkaYTzJGlHVs7zwrDt[YRq[XSnZDDwbI9{eGixconsZZRqd25ib3[gV3RCXDFuIGPURXQzKGGwZDDTWGFVOw>? M3zJblI1OjFzM{K3
HTR8/SVneo NFLGcmxHfW6ldHnvckBCe3OjeR?= MYmxxsDPxE4EoB?= NXP2c5JxOcLiaB?= MVLzeZBxemW|c3XkJG9UVS2rbnT1Z4VlKFOWQWSzJJBpd3OyaH;yfYxifGmxbh?= NX2yNYpiOjRyNkCyOFE>
HTR8/SVneo NF;lWpBHfW6ldHnvckBCe3OjeR?= M1HvU|AvPS9zwrFOwG3DqA>? MYK0PEBp NX\qWYp4emW|dH;y[ZMhfGinIHX4dJJme3Orb36gc4YhTS2lYXTo[ZJqdiC|dYDwdoV{e2WmIHL5JG9UVQ>? M3rFclI1ODZyMkSx
HTR8/SVneo MVfGeY5kfGmxbjDBd5NigQ>? Mk[xNeKh|ryPwrC= MYe0PEBp NIq0Uo9{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczDtbYdz[XSrb36gZpkhV1OPwrC= MlzJNlQxPjB{NEG=
C13* MlK1RZBweHSxc3nzJGF{e2G7 NIC1OVgxNTFyIN88US=> M2TLSVI1NzR6IHi= MWfpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3WgZY5lKHSrbXWg[IVx\W6mZX70JI1idm6nch?= NH:3NpMzOzl4MkW1PC=>
OV2008 MWXBdI9xfG:|aYOgRZN{[Xl? NHnUbWQxNTFyIN88US=> NF7XeWszPC92ODDo MYPpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3WgZY5lKHSrbXWg[IVx\W6mZX70JI1idm6nch?= NYLxbYN2OjN7NkK1OVg>
C13* NVvvNGpwSXCxcITvd4l{KEG|c3H5 MVWyOE81QCCq MYflcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= MYGyN|k3OjV3OB?=
OV2008 M3XlN2Fxd3C2b4Ppd{BCe3OjeR?= MXiyOE81QCCq MWjlcohidmOnczDjbZNxdGG2aX6tbY5lfWOnZDDhdI9xfG:|aYO= NF\WT3AzOzl4MkW1PC=>
W480  MlHESpVv[3Srb36gRZN{[Xl? MWqyMlUwOTBizszN NVTHflJ[OzBibXnu M{DTSmROW09? NGPRboF{\W6|aYTpfoV{KGOnbHzzJJRwKGOqZX3vdoFlcW:2aHXyZZB6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MVKyN|k{PDl5Mh?=
SW837 M2nGd2Z2dmO2aX;uJGF{e2G7 M4nrdlIvPS9zMDFOwG0> M3P0VVMxKG2rbh?= MV\EUXNQ M33JcJNmdnOrdHn6[ZMh[2WubIOgeI8h[2inbX;yZYRqd3SqZYLhdJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NXjnWmxWOjN7M{S5O|I>
T24 NYjoWW5vTnWwY4Tpc44hSXO|YYm= NHv4fHAzNzFyL{KwJO69VQ>? NHjXOXIzPCCq NGrTN2Zk[XW|ZYOg[I9{\S2mZYDlcoRmdnRiaX7obYJqfGmxbjDv[kB1cGViQ2jDUFEzNWmwZIXj[YQhcW6lcnXhd4Uhd2ZiaX72ZYRqdmdiY3XscJM> NG\PVZAzOzV{NkC3PS=>
CNE1 NGPlenhHfW6ldHnvckBCe3OjeR?= M3fOcVIxKML3TR?= MU[0PEBp NU\XNXk{[myxY3vzJJRp\SCLTD22JIlv[3KnYYPl[EBxcG:|cHjvdplt[XSrb36gc4YhW3SjdEO= Mn7xNlM{QDJ7MUS=
CNE2 NFzZTnJHfW6ldHnvckBCe3OjeR?= Mn7iNlAhyrWP NX3zUlVmPDhiaB?= MmLTZoxw[2u|IITo[UBKVC14IHnuZ5Jm[XOnZDDwbI9{eGixconsZZRqd25ib3[gV5RifDN? NHXaOGgzOzN6MkmxOC=>
HONE1 NYn3XotbTnWwY4Tpc44hSXO|YYm= MWqyNEDDvU1? NG\mbFM1QCCq M33ZfIJtd2OtczD0bIUhUUxvNjDpcoNz\WG|ZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJHN1[XR| MUCyN|M5OjlzNB?=
CNE1 M1PUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDWNmg1KM7:TR?= NEfjZ4V{cWewaX\pZ4FvfGy7IILl[JVk\XNiY3XscEB3cWGkaXzpeJk> Mmn5NlM{QDJ7MUS=
CNE1 NX21cVZMTnWwY4Tpc44hSXO|YYm= NIHVT3kxNTJyIN88US=> MkLlNE01KGh? NEfoVldqdmirYnn0d{BUfGG2MzDhZ5RqfmG2aX;uJIlvKGFiZH;z[U0h[W6mIITpcYUu\GWyZX7k[Y51KG2jbn7ldi=> NVTvNHRTOjN|OEK5NVQ>
CNE2 MmHpSpVv[3Srb36gRZN{[Xl? NFntdm4xNTJyIN88US=> MVOwMVQhcA>? Mn\0bY5pcWKrdIOgV5RifDNiYXP0bZZifGmxbjDpckBiKGSxc3WtJIFv\CC2aX3lMYRmeGWwZHXueEBu[W6wZYK= NV7NXWYzOjN|OEK5NVQ>
HONE1 NVXLTYZpTnWwY4Tpc44hSXO|YYm= MU[wMVIxKM7:TR?= MUewMVQhcA>? NXf0SnhIcW6qaXLpeJMhW3SjdEOgZYN1cX[jdHnvckBqdiCjIHTvd4UuKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> NW\S[llGOjN|OEK5NVQ>
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RAW264.7 MXjBdI9xfG:|aYOgRZN{[Xl? NEHmTog2NzFyIN88US=> NV\uVVRXPDVibXnu NGn0[VRmdmijbnPld{B1d3irboOgbY5lfWOnZDDhdI9xfG:|aYOgZY5lKE2PUDDsc5N{ M1ezRlIzPDV2NEOx
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HCT116 NUf5b2lUS2WubDDWbYFjcWyrdImgRZN{[Xl? MXi1M|ExNzJyIN88US=> MnnhO|IhcA>? MorqbY5pcWKrdIOgZ4VtdCC4aXHibYxqfHlib3[geIhmKEGORFirM2NFOTN|K9MgZ4VtdHN? MWOyNVkxODN7Nx?=
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SNU387  MXvD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NEXWdlgzOMLizszNxsA> NWDyUol2OjRiaB?= MmeydoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? Mmi0NlE{OTF7N{W=
SNU398 NXe5O5FNS2WubDDWbYFjcWyrdImgRZN{[Xl? NFjYSYYzOMLizszNxsA> MYqyOEBp MnvsdoVlfWOnczDj[YxtKH[rYXLpcIl1gQ>? MoDCNlE{OTF7N{W=
HepG2 NYLl[HBGS2WubDDWbYFjcWyrdImgRZN{[Xl? M4j0RVIxyqEQvF5CpC=> MViyOEBp NWrNW|NqemWmdXPld{Bk\WyuII\pZYJqdGm2eR?= NFHSW5gzOTNzMUm3OS=>
Huh-7 NYnmRms{S2WubDDWbYFjcWyrdImgRZN{[Xl? MnfaNlDDqM7:TdMg M{fwZ|I1KGh? M1\JeJJm\HWlZYOgZ4VtdCC4aXHibYxqfHl? MVeyNVMyOTl5NR?=
VSMC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3XWGc{NzVxMUCg{txO NVjmSWF1OzBibXnu NHO0bJVFVVOR MmmwdJJmfmWwdIOgVGRITi1iYX7kJJRpem:vYnnuMY1m\GmjdHXkJHZUVUNicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M1vF[VIxQDR5M{C2
MDA-MB-231 NWLhdnc5SXCxcITvd4l{KEG|c3H5 NH3ZXmQyOCEQvF2= NHrt[YszPCCq NIfjOoNFVVORwrC= M1PyR4lv\HWlZYOgZZBweHSxc3nz NG[zVYgyPzFzNECwOS=>
MDA-MB-435S MXzBdI9xfG:|aYOgRZN{[Xl? M1jzS|ExKM7:TR?= MUeyOEBp M2PhPWROW00EoB?= NEPLTldqdmS3Y3XzJIFxd3C2b4Ppdy=> NXn2W4NoOTdzMUSwNFU>

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay
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High-Throughput Screening and Fluorescence Polarization Assays :

Screening is performed at approximately 30 °C. The specificity of screening hits is validated in analogous assays for binding of the test compounds to the SH2 domains of STAT1, STAT5, and Lck. The final concentration of buffer components used for all FP assays is 10 mM HEPES (pH 7.5), 1 mM EDTA, 0.1% Nonidet P-40, 50 mM NaCl, and 10% DMSO. The absence of dithiothreitol is essential for inhibitory activity. The sequences of the peptides are: STAT3, 5-carboxyfluorescein-GY(PO3H2)LPQTV-NH2; STAT1, 5-carboxyfluorescein-GY(PO3H2)DKPHVL; STAT5, 5-carboxyfluorescein-GY(PO3H2)LVLDKW; and Lck, 5-carboxyfluorescein-GY(PO3H2)EEIP. For specificity analysis at 30 °C, proteins are used at 150 nM (STAT1, STAT3, and STAT5). For specificity analysis at 37 °C, proteins are used at 370 nM (STAT3) or 100 nM (Lck). Proteins are incubated with test compounds in Eppendorf tubes at the indicated temperatures for 60 min prior addition of the respective 5-carboxyfluorescein labeled peptides (final concentration: 10 nM). Before measurement at room temperature, the mixtures are allowed to equilibrate for at least 30 min. Test compounds are used at the indicated concentrations diluted from a 20× stock in DMSO. Binding curves and inhibition curves are fitted with SigmaPlot. All competition curves are repeated three times in independent experiment
Cell Research
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  • Cell lines: Ly3 cells
  • Concentrations: ~2.5 μM
  • Incubation Time: 48 h
  • Method: MTS
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.87 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 2% DMSO+30% PEG 300+H2O 8mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.19
Formula

C8H5NO4S

CAS No. 19983-44-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to dissolve the compound for i.p. injection, could you give me some suggestions?

  • Answer:

    S7024 Stattic can be dissolved in 2% DMSO/PEG 300/dd H2O at 8 mg/mL as a clear solution.

STAT Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID