STAT3 Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
Niclosamide can inhibit DNA replication and inhibit STAT with IC50 of 0.7 μM.
|Selective||STAT3, IC50: 0.7 μM|
Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5.
|Selective||STAT3, IC50: 4.6 μM|
Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.
|Selective||STAT3, IC50: 5.1 μM|
S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5.
|Selective||STAT3, IC50: 86 μM|
HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
|Pan||STAT3, Kd: 300 nM|
Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells