STAT

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STAT Inhibitors (8)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1155 S3I-201 S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.
  • Cancer Discov, 2013, 3(2):158-67
  • Clin Cancer Res, 2015, 10.1158/1078-0432.CCR-15-0016
  • Sci Signal, 2014, 7(322):ra38
S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor and a DNA synthesis inhibitor in Vascular smooth muscle cells.
  • EMBO Mol Med, 2015, 10.15252/emmm.201404580
  • Mol Cancer Ther, 2014, 13(10):2276-87
  • Mol Cancer Ther, 2013, 12(7):1299-309
S7024 Stattic Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.
  • Antioxid Redox Sign, 2015, 10.1089/ars.2015.6315
  • Antioxid Redox Signal, 2015, 10.1089/ars.2015.6315
  • J Biol Chem, 2013, 288(8):5553-61
S3030 Niclosamide Niclosamide can inhibit DNA replication and inhibit STAT with IC50 of 0.7 μM in a cell-free assay.
S4182 Nifuroxazide Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.
S7337 SH-4-54 SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
  • Diabetologia, 2015,
  • Diabetologia., 2015, 10.1007/s00125-015-3670-0
  • Int J Cancer, 2015, 10.1002/ijc.29558
S2285 Cryptotanshinone Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5.
S7501 HO-3867 HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1155 S3I-201 <1 mg/mL 73 mg/mL <1 mg/mL
S1491 Fludarabine <1 mg/mL 57 mg/mL <1 mg/mL
S7024 Stattic <1 mg/mL 42 mg/mL <1 mg/mL
S3030 Niclosamide <1 mg/mL <1 mg/mL <1 mg/mL
S4182 Nifuroxazide <1 mg/mL 55 mg/mL <1 mg/mL
S7337 SH-4-54 <1 mg/mL 100 mg/mL 50 mg/mL
S2285 Cryptotanshinone <1 mg/mL 5 mg/mL 1 mg/mL
S7501 HO-3867 <1 mg/mL 13 mg/mL 6 mg/mL
Tags: STAT inhibition | STAT signaling pathway | STAT pathway | STAT cancer | STAT signaling | STAT protein | STAT activation | JAK-STAT signaling pathway | STAT3 pathway | STAT3 cancer | STAT3 inhibition | STAT3 activation | STAT phosphorylation | STAT3 protein | STAT1 inhibition | STAT1 pathway | STAT1 activation | STAT1 protein | JAK-STAT mechanism | STAT3 inhibitors in clinical trials | STAT3 inhibitor in vivo | STAT inhibitor review
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