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S3804
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Alpha-Mangostin
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Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
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S3808
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Mangiferin
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Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. This compound is a Nrf2 activator. It suppresses nuclear translocation of the NF-κB subunits p65 and p50.
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S3810
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Scutellarin
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Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. This compound can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
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S3811
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Ginsenoside Re
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Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. This compound decreases the β-amyloid protein (Aβ). It plays a role in antiinflammation through inhibition of JNK and NF-κB.
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S3891
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Vincamine
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Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.
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S3813
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Bakuchiol
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Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., This compound is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
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S3919
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Hederacoside C
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Hederacoside C (HDC, Kalopanaxsaponin B) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and used to treat respiratory disorders.
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S3837
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Echinocystic acid
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Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.
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S3844
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Rosavin
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Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities.
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S3846
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Eupatilin
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Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. This compound, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
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S3779
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cis-Anethole
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Anethole ((Z)-Anethole, Cis-p-Propenylanisole, Cis-p-Anethole) has two isomers, the cis(Z) isomer being 15-38 times more toxic to animal than the trans(E) isomer. cis-Anethole is found in anise and Only a low level is permitted in flavours.
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S3782
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Neomangiferin
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Neomangiferin (Mangiferin 7-glucoside), a natural xanthone C-glycoside mainly obtained from the well-known traditional Chinese medicine rhizoma of Anemarrhena asphodeloides, exhibits antidiabetic activity and antiosteoporotic action.
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S3783
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Echinacoside
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Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. This compound, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. It also has a remarkable antiosteoporotic activity.
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S3777
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Gentiopicroside
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Gentiopicroside (GE, Gentiopicrin), a naturally occurring iridoid glycoside, inhibits CYP2A6 and CYP2E1 with IC50 values of 21.8μg/ml and 594μg/ml, respectively in human liver microsomes, and this compound does not inhibit CYP2C9, CYP2D6, CYP1A2 or CYP3A4 activities.
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S3784
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Obacunone (AI3-37934)
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Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. This compound significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; it is also a novel activator of Nrf2.
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S3786
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Glabridin
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Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.
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S3787
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Picroside I
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Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
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S3780
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Secoisolariciresinol diglucoside
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Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.
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S3914
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α-Hederin
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α-hederin is a water-soluble pentacyclic triterpenoid saponin which has shown hemolytic and apoptotic properties.
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S3929
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Liquiritigenin
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Liquiritigenin (4',7-Dihydroxyflavanone), the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.
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