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S5599
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Sodium cholate
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Sodium cholate (NaCh) is the sodium salt of the naturally occurring cholic acid, a bile salt produced by the liver, with strong solubilization capacity of water-insoluble substances.
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S5575
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2-Benzoxazolinone
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2-Benzoxazolinone (BOA, 2-Hydroxybenzoxazole), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate and probably functions via interfering with auxins or disrupting membrane integrity.
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S5579
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Chelidonic acid
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Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxyl acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. This compound inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. It is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
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S5588
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Creatine
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Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue. This compound can inhibit the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
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S5614
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(+)-Longifolene
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(+)-Longifolene is a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins
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S5595
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3-Carene
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3-Carene (Carene, Delta-3-Carene) is a bicyclic monoterpene in essential oils extracted from pine trees. This compound has potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. It is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.
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S5376
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Decyl aldehyde
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Decyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring.
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S5551
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6-Paradol
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6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities. Paradol is an inhibitor of cyclooxygenase (COX)-2.
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S5379
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Fenchyl Alcohol
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Fenchyl Alcohol is used as a flavoring agent to provide a pine, herbal, lemon, or floral taste to food and drink.
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S5530
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Geraniol
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Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants used in the flavour and fragrance industries. It also exhibits insecticidal and repellent properties and used as a natural pest control agent exhibiting low toxicity.,
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S5237
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Dihydroartemisinic acid
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Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to treat Malaria.
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S5516
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Ellagic Acid hydrate
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Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.
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S3612
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Rosmarinic acid
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Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.
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S3609
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Berbamine dihydrochloride
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Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
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S5459
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Aucubin
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Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.
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S5471
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Monotropein
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Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.
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S5452
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Sanguinarine chloride
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Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
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S5458
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Verbascoside
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Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.
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S5467
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Asarinin
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Asarinin (Sesamin, Fagarol, Pseudocubebin, Episesamin, Eleutheroside B4), isolated as a racemate from the shrub Zanthoxylum alatum, is usually used as a dietary fat-reduction supplement.
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S5455
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Akebia saponin D
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Akebia saponin D (Asperosaponin VI), the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.
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