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Natural Product Library
Cat.No. Product Name Information
S2365 Tanshinone IIA Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; this compound is a natural monoacylglycerol lipase inhibitor.
S2366 Taxifolin (Dihydroquercetin) Taxifolin (Dihydroquercetin), a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on, is a type I inhibitor for VEGFR-2 kinase.
S2368 Theobromine Theobromine (3,7-Dimethylxanthine) is a xanthine alkaloid widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs.
S2371 Vanillylacetone Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. This compound alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. It acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.
S2372 Xanthone Xanthone (Genicide) is an organic compound, which can be prepared by the heating of phenyl salicylate.
S2373 Yohimbine HCl Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
E2794 Garcinone D Garcinone D is a natural xanthone from mangosteen, an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 with an IC50 of 28.23 μM. It promotes neural stem cell proliferation via STAT3 and Nrf2/HO-1 activation while inhibiting prostate and breast cancer growth by blocking the CDK2/CyclinE1-mediated cell cycle and can be used in prostate and breast cancer research.
E2758 Robinin Robinin is a flavonoid that acts by inhibiting TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin reduces oxidized-LDL-induced TLR2 and TLR4 expression at the mRNA level and prevents NF-κB p65 nuclear translocation by regulating TLR-NF-κB signaling. Robinin exhibits anti-inflammatory and anti-tumor effects.
E2709 Halofuginone hydrobromide Halofuginone (RU-19110) hydrobromid, a febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity.
E2723 QS-21 QS-21 (QS-21-Api; Stimulon) is a natural saponin vaccine adjuvant derived from Quillaja saponaria bark that enhances both Th2 humoral and Th1 cell-mediated immune responses by acting on antigen-presenting cells (APCs) and T cells. It activates the NLRP3 inflammasome, leading to caspase-1-dependent release of IL-1β and IL-18 cytokines, which are critical for Th1 immunity and control of intracellular pathogens.
E2741 7-ketocholesterol 7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.
E2582 kamebakaurin Kamebakaurin is a diterpene isolated from Isodon japonicus, it is a potent inhibitor of NF-kappaB activation by directly targeting DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-κB target genes. It can be used in research of pathological conditions such as inflammation and cancer.
E2456 Soyasaponin Bb Soyasaponin Bb, a soyasaponin isolated from Phaseolus vulgaris, is an aldose reductase (AKR1B1) differential inhibitor (ARDI).
E2477 Cephaeline Cephaeline ((-)-Cephaeline; NSC 32944 free base), a desmethyl analog of emetine, is a potent Zika virus (ZIKV) and Ebola virus (EBOV) infection inhibitor. Cephaeline is also an, histone H3 acetylation inducer and inhibits cellular viability, growth, and migration of mucoepidermoid carcinoma cancer stem cells.
S4745 L-Phenylalanine L-Phenylalanine is an essential amino acid and a competitive antagonist against NMDAR glycine- and glutamate-binding sites with a Kb of 573 μM. It is widely used in food flavor and pharmaceutical production.
E2309 Glucoraphanin Glucoraphanin, a natural glucosinolate found in cruciferous vegetables, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects. Glucoraphanin inhibits tumor necrosis factor alpha (TNFα)-induced Caco-2 cells monolayers inflammation and permeabilization through the regulation of redox-sensitive events.
E0755 Guvacoline hydrochloride Norarecoline hydrochloride (Guvacoline hydrochloride) is a pyridine alkaloid found in Areca triandra, which can act as a full agonist at both atrial and ileal muscarinic receptors.
E0760 Neotuberostemonine Neotuberostemonine (NTS), one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, has a significant effect on BLM-induced pulmonary fibrosis by inhibiting macrophage recruitment and M2 polarization protective effect.