Home Endocrinology & Hormones Glucocorticoid Receptor

Glucocorticoid Receptor Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S1696 Hydrocortisone (Cortisol) Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.
Bone Res, 2025, 13(1):37
Clin Cancer Res, 2025, 10.1158/1078-0432.CCR-24-1812
Cell Death Discov, 2025, 11(1):286
S1737 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. This compound is widely used in the treatment of various inflammatory and autoimmune conditions. It works by suppressing the immune response and reducing inflammation in the body. The efficacy of this medication has been well-documented in clinical studies. Patients prescribed this drug should follow their healthcare provider's instructions carefully to minimize potential side effects.
Cancers (Basel), 2025, 17(12)2034
Front Oncol, 2025, 15:1520972
Molecules, 2024, 29(7)1546
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S5956 Dexamethasone phosphate disodium Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Cell Rep, 2023, 42(6):112566
Blood Adv, 2023, 7(4):469-481
S2559 Cortisone acetate Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.
Cancer Immunol Immunother, 2025, 74(10):316
iScience, 2024, 27(10):110862
J Pers Med, 2022, 12(2)258
S1286 Budesonide Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
Arch Toxicol, 2025, 99(3):1105-1116
bioRxiv, 2025, 2025.03.31.646052
Front Mol Neurosci, 2024, 17:1473960
S4646 Ciclesonide Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
bioRxiv, 2025, 2025.06.23.660251
Acta Pharm Sin B, 2023, 13(2):662-677
Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736.
S4752 Corticosterone Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Brain Res Bull, 2025, 225:111346
Gen Psychiatr, 2024, 37(1):e101291
Biomater Res, 2024, 28:0010
S1622 Prednisone Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Chin Med, 2025, 20(1):135
Blood Cancer J, 2022, 12(3):36
Int J Mol Sci, 2022, 23(7)3834
S1628 Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. This compound is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
Arch Toxicol, 2025, 99(3):1105-1116
FASEB J, 2025, 39(1):e70298
J Transl Med, 2022, 20(1):561
S1992 Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Heliyon, 2024, 10(20):e39475
Cell Rep Methods, 2023, 3(4):100440
Cell Reports Methods, 2023, 10.1016/j.crmeth.2023.100440
S2570 Prednisolone Acetate Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.
Oncogene, 2024, 43(4):235-247
J Immunotoxicol, 2021, 18(1):154-162
Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S1733 Methylprednisolone Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis.
Food Chem Toxicol, 2024, 188:114665
Drug Test Anal, 2020, 10.1002/dta.2917
Nat Med, 2017, 23(4):424-428
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S2584 Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
Nat Commun, 2025, 16(1):699
Pharmacol Res, 2025, S1043-6618(25)00049-0
Exp Ther Med, 2019, 18(2):1258-1266
S1933 Triamcinolone Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
bioRxiv, 2025, 2025.08.03.668359
Gastroenterology, 2024, S0016-5085(24)00062-3
Drug Test Anal, 2020, 10.1002/dta.2917
S5685 Desoximetasone Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.
Free Radic Biol Med, 2023, 203:1-10
Cell Death Dis, 2022, 13(6):521
Autophagy, 2021, 10.1080/15548627.2021.2008692
S5489 Prednisone acetate Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.
Blood Cancer J, 2022, 12(3):36
Front Immunol, 2021, 12:739605
J Immunotoxicol, 2021, 18(1):154-162
S1987 Mometasone furoate Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.
Sci Rep, 2024, 14(1):30786
J Bone Oncol, 2024, 47:100618
S1500 Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
BMC Pharmacol Toxicol, 2024, 25(1):25
Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
S4088 Flumethasone Flumethasone (RS-2177, NSC-54702, Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Elife, 2023, 12e82249
Drug Test Anal, 2020, 10.1002/dta.2917
S1701 Desonide Desonide is a low potency topical corticosteroid.
Nat Commun, 2022, 13(1):4109
Drug Test Anal, 2020, 10.1002/dta.2917
S5184 Dexamethasone palmitate Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. This compound exhibits anti-inflammatory activity.
Dis Model Mech, 2022, dmm.049109
Hematology, 2022, 27(1):32-42
S1669 Loteprednol etabonate Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.
Int J Biol Macromol, 2025, 306(Pt 3):141644
S1888 Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Drug Test Anal, 2020, 10.1002/dta.2917
S2470 Fluocinolone Acetonide Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.
Acta Pharm Sin B, 2023, 13(2):662-677
S1688 Betamethasone Dipropionate Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
J Nanobiotechnology, 2024, 22(1):706
S5486 Fluorometholone Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.
Drug Test Anal, 2020, 10.1002/dta.2917
S1689 Meprednisone Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1690 Betamethasone Valerate Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2608 Fluocinonide Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078 Beclomethasone dipropionate Beclomethasone dipropionate(Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617 (20S)-Protopanaxatriol (20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).
S5973 Methylprednisolone Acetate Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
S4228 Fluorometholone Acetate Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
E4918 BecloMethasone Beclomethasone(Beclometasone) is a prototype agonist of glucocorticoid receptor. Beclomethasone and its derivatives display have higher binding affinity to glucocorticoid receptors in rat liver, thymus, and hypophysis.
S4775 Cortodoxone Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.
S1322 Dexamethasone Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Signal Transduct Target Ther, 2025, 10(1):230
Signal Transduct Target Ther, 2025, 10(1):394
Gut, 2025, gutjnl-2025-336105
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S4028 Dexamethasone Sodium Phosphate Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Proc Natl Acad Sci U S A, 2025, 122(12):e2426107122
J Tradit Chin Med, 2025, 45(4):739-746
Cancer Cell, 2024, 42(9):1507-1527.e11
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